Toxicology Seminar Series: Marcelo Bonini, PhD, April 26

Please join us for our LAST Spring 2018 seminar taking place this Thursday, April 26, from 11:45
am – 1:00 pm in Field Auditorium, Environment Hall.
 Marcelo Bonini, PhD, Associate Professor at the Medical College of Wisconsin, will be speaking about “
SOD2 acetylation as a mitochondrial pathway to stemness in cancer.”
 
Abstract:
The talk will describe how a novel post-translational modification of SOD2 (K68 acetylation) converts the enzyme from a protective mitochondrial antioxidant to an agent that promotes reprogramming to stem-like cancer cell phenotypes. Implications for tumor progression and metastasis will be discussed.
 
Bio:
Dr. Bonini grew up in Brazil and witnessed firsthand the devastating effects of an inadequate environment on children and women’s health. He received a Ph.D. in Biochemistry and Molecular Biology in 2004 from the University of Sao Paulo, Brazil. Soon after, he began his postdoctoral training at the National Institute of Environmental Health Sciences (NIEHS) focusing on the understanding of how redox driven reactions affect signaling events relevant for the maintenance of the cellular homeostatic balance and disease. In 2009, Dr. Bonini established an independent, multidisciplinary program focused on the identification of redox sensitive pathways involved in tumor progression and metastasis at the University of Illinois at Chicago. Just this spring, he took a position as Associate Professor at the Medical College of Wisconsin in Milwaukee.

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