Jan 30, 2020: Mutagenicity and Carcinogenicity of Combustion Emissions

Spring 2020 Seminar Series (Pharm 848-S/ENV 848-S)

Duke Integrated Toxicology & Environmental Health Program

Thursday, January 30, 2020, 11:45 am – 1:00 pm, Field Auditorium, Grainger Hall

DAVID DeMARINI, PH.D.David DeMarini, PhD


Mutagenicity and Carcinogenicity of Combustion Emissions: Biomarkers & Risk for Cancer

Combustion emissions, such as those from woodsmoke or coal, are well-documented probable or known human lung carcinogens, and they contribute substantially to the mutagenicity and carcinogenicity of indoor and outdoor air pollution. This presentation reviews 40 years of data on the mutagenicity (in Salmonella and humans) and carcinogenicity (in rodents and humans) of a wide range of combustion emissions. The impact of exposure to these emissions are discussed.


BIOGRAPHY: Dr. DeMarini did his BS, MS, and PhD at Illinois State University, Normal, IL, in genetic toxicology. After 3 years of postdoc at the Oak Ridge National Laboratory and 2 years at NIEHS/NTP, he joined the U.S. EPA in RTP in 1985. He has been an Adjunct Professor in the School of Public Health at UNC for 35 years and mentored 10 PhD students and 10 postdocs. He has given the lectures on mutagenesis and carcinogenesis in the Mammalian Toxicology course PHR 254 at Duke University School of Medicine for 20 years. He has published >200 papers, been the President of the national and international Environmental Mutagenesis and Genomics Society, and he has been the Editor-in-Chief for 21 years of Mutation Research—Reviews. He has served on 9 Working Groups of the international Agency for Research on Cancer (IARC/WHO), chairing 2 of them. His research interests are the mutagenicity of complex mixtures, mutational mechanisms, and genotoxicity biomonitoring.


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