Oct 14, 2022: Mechanistic understanding of ultrafine carbon and ozone mixed inhalation exposures induced lung toxicity

Formal headshot of seminar speaker, Dr. Salik Hussain, wearing a gray-blue suit and tie

Salik Hussain, DVM, PhD

School of Medicine

West Virginia University

Lab Website

Environmental inhalation exposures are inherently mixed (gases and particles), yet regulations are still based on single toxicant exposures. While the impacts of individual components of environmental pollution have received substantial attention, the impact of inhalation co-exposures is poorly understood. We have recently developed and validated inhalation co-exposure system for ultrafine carbon black (CB) and ozone (O3) exposure. This talk will cover detailed characterization of co-exposure aerosols and their cellular and acellular reactivity. Characterization of ozone aggravated oxidant generation abilities of carbon particles using electron paramagnetic resonance (EPR) will be presented. Moreover, transcriptomic, biochemical, physiological and cellular/molecular evidence of enhanced biological activity of co-exposure aerosols will be presented. In addition, novel findings on co-exposure induced altered lung remodeling in an acute lung injury and contribution of Nod like receptor X1 (NLRX1) will be presented.

About the Speaker: Dr. Hussain is currently working as an Assistant Professor in the Department of physiology and Pharmacology at West Virginia University.  Dr. Hussain received DVM and Masters in Pathology degrees from Pakistan. Dr. Hussain received European Doctorate in Toxicology from University Paris Diderot, Paris, France in 2010 and was a postdoctoral fellow at the National Institute of Environmental Health Sciences (NIEHS) from 2011-2017. Dr. Hussain serves as an academic editor for the journal PLOS One, Review editor Frontiers in Toxicology and as an associate editor for Advances in Redox Research. He also serves as an ad hoc reviewer for more than 20 journals. He is author/co-author of 43 peer-reviewed articles and/or book chapters. He has delivered multiple invited talks at international conferences including ATS and SOT annual meetings. His research work has won multiple awards from SOT including Outstanding Postdoctoral Achievements Award and Best publication of the Year Awards.  He is current President of the Nanoscience and Advanced Materials (NAMSS) specialty section of the Society of Toxicology (SOT) USA. Dr. Hussain’s research program is funded through Outstanding New Environmental Scientist (ONES) Award by the NIEHS/NIH.

Friday, October 14, 2022, 12:00-1:15 pm Eastern

Field Auditorium Room 1112, Grainger Hall (9 Circuit Dr, Durham, NC)

Masks are now optional for in-person attendees. Please stay home if you aren’t feeling well – you may attend via Zoom instead (see below).

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