José E Manautou, PhD, ATS Fellow
Dept. Head of Pharmaceutical Sciences
Assistant Dean for Graduate Education and Research
Professor of Toxicology
University of Connecticut School of Pharmacy
He / Him / His
Hepatic transporters are important determinants of drug pharmacokinetics and drug-induced liver toxicity (DILI). The expression of drug transporters, such as the multidrug resistance-associated protein 4 (Mrp4), is known to be altered in response to DILI. Induction of Mrp4 is observed in hepatocytes undergoing compensatory proliferation. To further understand the relationship between Mrp4 function and liver cell regeneration, a partial hepatectomy model in mice genetically deficient in Mrp4 was employed. Contrary to expectations, lack of Mrp4 does not alter hepatocyte proliferation following PH. However, an unexpectedly, Mrp4 knockout mice developed hepatic steatosis during tissue regeneration. We also observed that the lack on Mrp4 promotes adipogenesis and insulin resistance. Overall, recent observations from our laboratory indicate that Mrp4 is a novel genetic factor in the development of hepatic steatosis and metabolic syndrome.
About the Speaker: José E. Manautou is the Department Head of Pharmaceutical Sciences, Assistant Dean of Graduate Education and Research and Professor of Toxicology at the University of Connecticut (UConn) School of Pharmacy. His long-term research interests are on biochemical and molecular mechanisms of xenobiotic-induced hepatotoxicity and defining compensatory responses to liver injury that enhance tissue resistance to toxicant re-exposure. Manautou has published over 200 originally research articles, abstracts, commentaries and other reports. He is also a Fellow of the Academy of Toxicological Scienes. He is Co-Editor-in-Chief of the journal Current Opinions in Toxicology and the President-Elect of the International Union of Toxicology. Manautou obtained his BS in pharmacy from the University of Puerto Rico, Ph.D. in pharmacology and toxicology at Purdue University in 1991, and postdoctoral training at the University of Connecticut. He also conducted sabbatical training at the Academic Medical Center in Amsterdam.
Friday, September 17, 12:00-1:15 pm Eastern
Field Auditorium Room 1112, Grainger Hall (9 Circuit Dr, Durham, NC)
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