Fall 2020 Seminar Series (ENV 847-S/PHARM 847-S)
Duke Integrated Toxicology & Environmental Health Program
Friday, September 4, 2020, 12:00 – 1:15 pm
*Live Zoom Presentation. Register HERE to receive Zoom link!*
XABIER ARZUAGA, PhD
U.S. EPA, Office of Research and Development
Applying the Adverse Outcome Pathway (AOP) framework to evaluate human relevance of dibutyl phthalate-induced male reproductive effects
Xabier Arzuaga is a Toxicologist at the U.S. EPA’s Center for Public Health and Environmental Assessment (CPHEA). His work is focused on the evaluation of toxicological and mechanistic evidence captured in IRIS Toxicological Reviews. His seminar titled: “Using the Adverse Outcome Pathway framework to evaluate human relevance of Dibutyl phthalate-induced male reproductive effects” will describe recent approaches used to screen and analyze mechanistic and toxicological evidence for dibutyl phthalate (DBP) in order to address the human relevance of effects observed in rodent models studies.
BIOGRAPHY: Dr. Arzuaga received his B.Sc. from the University of Puerto Rico in Coastal Marine Biology, his PhD from the University of Kentucky Graduate Center for Toxicology, and his postdoc from the University of Kentucky Graduate Center for Nutritional Sciences. Since joining the EPA, Xabier has worked on several assessments including uranium, dibutyl phthalate, hexavalent chromium, and, most recently, perfluorinated compounds. Dr. Arzuaga has also worked on the development and implementation of systematic review practices in CPHEA.