Subham Dasgupta, PhD
Assistant Professor, Department of Biological Sciences
Clemson University
He/His
Description: In this presentation, I will talk about part of the research going on in my lab for the past 1.5 years, studying impacts of flame retardant tetrabromobisphenol A (TBBPA) on early development, using zebrafish as a model. Our studies show that TBBPA exposures result in pre-pluripotent developmental delays and subsequent disruption of dorsoventral patterning- an event that establishes the embryonic axis. The talk will cover our work encompassing TBBPA-induced impacts on maternal-to-zygotic transition and our efforts to interrogate the role of histone acetylation and P300 histone acetyltransferase protein as a primary target of TBBPA and developmental delays. The talk will also cover studies on dorsoventral patterning, interrogating the modes of action driving TBBPA-induced “ventralization” phenotypes. I will specifically talk about bone morphogenetic protein signaling as well as transcription factors and cell adhesion proteins involved in epithelial-to-mesenchymal transition as specific targets of TBBPA across developmental time points.
About the speaker: I am an Assistant Professor of Environmental Toxicology at the Department of Biological Sciences, Clemson University. I received my BS in Human Physiology and MS in Environmental Sciences from the University of Calcutta, India. Following this, I received my PhD from Dr. Anne McElroy’s Lab at Stony Brook University in NY working on the Deepwater Horizon oil spill and crude/dispersed oil toxicity. Subsequently, I conducted my postdoctoral research in Dr. David Volz’s lab working with flame retardants and zebrafish model and Dr. Robyn Tanguay’s Lab at Oregon State, working on long noncoding
RNAs. I started my lab at Clemson in August 2022 and since then, have been building my research program through multiome studies on developmental toxicity of flame retardants, PFASs and PAHs. Currently, I supervise 4 graduate students and 1 postdoc. In addition to a NIGMS-funded COBRE pilot project, I recently received an NIEHS R03 to study histone acetylation during maternal-to-zygotic transition in flame retardant exposures.
Friday, September 13, 2024, 12:00-1:15pm Eastern
Field Auditorium, Room 1112, Grainger Hall (9 Circuit Drive, Durham, NC)
This seminar will also be presented live via Panopto. Click HERE for the livestream.
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