ITEHP Seminar: Genetic & epigenetic factors that mitigate hydrogen sulfide toxicity in metazoans

DANA MILLER, PhD

University of Washington

Pronouns: She / Her / Hers or They / Their / Theirs

Genetic and epigenetic factors that mitigate H₂S toxicity in metazoans

Hydrogen sulfide (H₂S) is a toxic gas that is a common environmental and industrial toxin. H₂S is also produced endogenously, and is an important cellular signaling molecule. Treatment with exogenous H₂S can protect mammals against cell damage and death from ischemia/reperfusion. The mechanism of H₂S toxicity is poorly understood, and there is little known about the relationship between beneficial and toxic effects of H₂S. We use the nematode, C. elegans, to explore genetic factors that mediate H₂S signaling and toxicity in animals.

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