TIMOTHY SHAFER, PhD
Research Toxicologist
Rapid Assay Development Branch
Biomolecular and Computational Toxicology Division
Center for Computational Toxicology and Exposure
US Environmental Protection Agency
Evaluating neurotoxicity hazard using human and rodent neural networks
Microelectrode array (MEA) recordings have been proposed as a way to screen compounds for neurotoxicity and developmental neurotoxicity. To date, most data have been generated in rodent cultures. However, recently, networks of human IPs-derived neurons are becoming increasingly available, and are being used for neurotoxicity screening. This presentation will provide an overview of the use of MEAs for neurotoxicity and developmental neurotoxicity screening, and compare data from rodent and human derived networks.