About Us

About Our Program

The Superfund Research Center (SRC) at Duke University focuses on early, low-dose exposures to toxins and their developmental impacts that are usually only evident during later life stages.  Duke has conducted Superfund-related research for over 15 years.  Our research has shifted over the years, as knowledge of Superfund chemicals and remediation techniques have improved and the questions being asked have changed. Each funding cycle is generally 5 years in length and consists of several research projects that are all working collaboratively to shed light on the overall focus of the Duke SRC. Our projects for the current grant cycle are listed below:

2017 – 2022 “Developmental Exposures: Mechanisms, Consequences, and Remediation”
  1. Cholinergic and Monoaminergic Mechanisms of Persistent Neurobehavioral Toxicity (Principal Investigator: Edward Levin)
  2. Altering the Balance of Adipogenic and Osteogenic Regulatory Pathways from Early Life Exposure to HPCs and AOPEs (Principal Investigator: Heather Stapleton)
  3. Persistent Mitochondrial and Epigenetic Effects of Toxicant Exposure (Principal Investigator: Joel Meyer)
  4. Mechanisms and Consequences of Evolved Adaptation to Environmental Pollution (Principal Investigator: Richard Di Giulio)
  5. Engineering the Physico-Chemical Environment to Enhance Polycyclic Aromatic Hydrocarbon (PAH) Bioremediation (Principal Investigator: Claudia Gunsch)

Support Cores (2017-2022)

Research Core A: Neurobehavioral Toxicity Core (Principal Investigator: Edward Levin)

Research Core B: Analytical Chemistry Core (Principal Investigator: Lee Ferguson)

Administration Core (Principal Investigator: Richard Di Giulio)

Training Core (Principal Investigator: Joel Meyer)

Research Translation Core (Principal Investigator: Charlotte Clark)

Community Engagement Core (Principal Investigator: Elizabeth Shapiro-Garza)

Below, we have listed the projects from the previous funding cycles. You can read more about our previous funding cycles and each project within those cycles by visiting our page on the NIEHS Superfund Research Program website.

2011 – 2017 “Early Life Exposures, Later Life Consequences”
  1. Developmental Neurotoxicants: Sensitization, Consequences, and Mechanisms
  2. Thyroid Metabolism Disruption in Toxicant-Induced Developmental Impairment
  3. Developmental PAH Exposures in Fish: Mechanisms of Toxicity, Adaptation, and Later Life Consequences
  4. Metal-based Nanoparticles for Groundwater and Surface Water Remediation: Limitations, Concerns, Synergies, and Antagonistic Effects in Bioremediation
2006 – 2011 “Superfund Chemicals’ Impact on Reproduction and Development”
  1. Developmental Neurotoxicity of Superfund Pesticides: Biomarkers and Mechanisms
  2. Neurobehavioral Mechanisms of Cognitive and Affective Impairment from Fetal Exposure to Superfund Chemicals
  3. Zebrafish as a Detector and Discriminator of Organophosphate Exposure
  4. Mechanisms of Environmental Stress-Induced Developmental Abnormalities
  5. Developmental Effects of Superfund Hydrocarbon Mixtures in Fundulus heteroclitus
  6. Microbial and Photolytic Transformations of Superfund Chemical
2000 – 2005 “Superfund Chemicals’ Impact on Reproduction and Development”
  1. Developmental Neurotoxicity of Chlorpyrifos: Mechanism and Consequences
  2. Fate, Transport, and Exposure Risk of Superfund Chemicals
  3. Markers for Chemical Mixtures in Fundulus Heteroclitus
  4. Mechanism of Stress-Induced Developmental Abnormalities
  5. Transgenic Fish as Biosensors for Superfund Chemicals