what we do
At our secret headquarters in room A304 of the Levine Science Research Center on the Duke University campus in Durham, North Carolina, we use the nematode Caenorhabditis elegans, a versatile model organism, as well as cells in culture in experiments aimed at improving environmental health. Our efforts range from studying the effects of environmental stressors at the molecular and cellular level to effects on the organism as a whole. We have a special interest in mitochondria, and mitochondrial and nuclear DNA damage. By collaborating with other researchers, we also study environmental health in people, other model organisms, and ecosystems.
If you are unfamiliar with environmental toxicology, mitochondria and mitochondrial DNA, or C. elegans (“worms”) and would like a short introduction, click the links below.
why we do it
Science is really fascinating and fun. But there is another reason. Pollution is a major health problem, especially in parts of the world with less environmental protection. It is responsible for at least 9 million premature deaths per year, more than AIDS, tuberculosis, and malaria combined. Most of this results from chronic disease, which will increase as the world’s population lives longer. Such diseases (cancers, neurodegenerative diseases, etc.) are also influenced by genetics, but genetics alone explains only 15-30% of most chronic diseases.
We have joined forces with other Duke ecoteams to battle eco-evil:
- The Nicholas School of the Environment
- Duke University Superfund Research Center
- The Integrated Toxicology and Environmental Health Program (ITEHP)
- The Duke Global Health Institute
- The Center for the Environmental Implications of Nanotechnology (CEINT)
- Civil and Environmental Engineering
Including regional groups:
- Research Triangle Environmental Health Collaborative
- North Carolina OneHealth Collaborative
- Genetics and Environmental Mutagenesis Society
- Carolinas Society of Environmental Toxicology and Chemistry
- North Carolina Society of Toxicology
- Triangle Worm Group
Here are some recent publications from our band of green crimefighters. For a full list, please go to Dr. Meyer’s Google Scholar profile (automatically updated), or his CV at his NSOE site (more or less regularly updated).
Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans. Current Research in Toxicology 2022.
The inclusion of sex and gender beyond the binary in toxicology. Frontiers in Toxicology 2022.
Rotenone modulates Caenorhabditis elegans immunometabolism and pathogen susceptibility. Frontiers in Immunology 2022.
In vivo effects of silver nanoparticles on development, behavior and mitochondrial function are altered by genetic defects in mitochondrial dynamics. Environmental Science and Technology 2022.
Mitochondrial DNA mutagenesis: feature of and biomarker for environmental exposures and aging. Current Environmental Health Reports 2021.
Quantifying levels of dopaminergic neuron morphological alteration and degeneration in Caenorhabditis elegans. Journal of Visualized Experiments 2021.
Lack of detectable direct effects of silver and silver nanoparticles on mitochondria in mouse hepatocytes. Environmental Science and Technology 2021.
Xenobiotic metabolism and transport in Caenorhabditis elegans. Journal of Toxicology and Environmental Health, Part B 2021.
Genetic defects in mitochondrial dynamics in Caenorhabditis elegans impact ultraviolet C radiation- and 6-hydroxydopamine-induced neurodegeneration. International Journal of Molecular Sciences, 2019.
Mitochondrial toxicity. Toxicological Sciences, 2018.
Mitochondrial fusion, fission, and mitochondrial toxicity. Toxicology, 2017.
This page contains a variety of resources, intended especially for members of my own lab but also potentially useful to other scientists or people interested in science.
Feel free to contact us by the traditional means (or you can always just light the Worm Beacon).