what we do

At our secret headquarters in room A304 of the Levine Science Research Center on the Duke University campus in Durham, North Carolina, we use the nematode Caenorhabditis elegans, a versatile model organism, as well as cells in culture in experiments aimed at improving environmental health. Our efforts range from studying the effects of environmental stressors at the molecular and cellular level to effects on the organism as a whole. We have a special interest in mitochondria, and mitochondrial and nuclear DNA damage. By collaborating with other researchers, we also study environmental health in people, other model organisms, and ecosystems.

If you are unfamiliar with environmental toxicology, mitochondria and mitochondrial DNA, or C. elegans (“worms”) and would like a short introduction, click the links below.

why we do it

Science is really fascinating and fun. But there is another reason. Pollution is a major health problem, especially in parts of the world with less environmental protection. It is responsible for at least 9 million premature deaths per year, more than AIDS, tuberculosis, and malaria combined. Most of this results from chronic disease, which will increase as the world’s population lives longer. Such diseases (cancers, neurodegenerative diseases, etc.) are also influenced by genetics, but genetics alone explains only 15-30% of most chronic diseases.

how we do it

We have joined forces with other Duke ecoteams to battle eco-evil:

Including regional groups:


Here are some recent publications from our band of green crimefighters. For a full list, please go to Dr. Meyer’s Google Scholar profile (automatically updated), or his CV at his NSOE site (more or less regularly updated).

Resistance of mitochondrial DNA to cadmium and Aflatoxin B1 damage-induced germline mutation accumulation in Caenorhabditis elegans. Nucleic Acids Research 2022.

Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans. Current Research in Toxicology 2022.

The inclusion of sex and gender beyond the binary in toxicology. Frontiers in Toxicology 2022.

Sex-specific DNA methylation and associations with in utero tobacco smoke exposure at mitochondrial genes. Epigenetics 2022.

Rotenone modulates Caenorhabditis elegans immunometabolism and pathogen susceptibility. Frontiers in Immunology 2022.

In vivo effects of silver nanoparticles on development, behavior and mitochondrial function are altered by genetic defects in mitochondrial dynamics. Environmental Science and Technology 2022.

Mitochondrial DNA mutagenesis: feature of and biomarker for environmental exposures and aging. Current Environmental Health Reports 2021.

Quantifying levels of dopaminergic neuron morphological alteration and degeneration in Caenorhabditis elegans. Journal of Visualized Experiments 2021.

Lack of detectable direct effects of silver and silver nanoparticles on mitochondria in mouse hepatocytes. Environmental Science and Technology 2021.

Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans. Redox Biology 2021.

Xenobiotic metabolism and transport in Caenorhabditis elegans. Journal of Toxicology and Environmental Health, Part B 2021.

Transgenic CYP1A expression in Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture. Toxicology 2020.

Genetic defects in mitochondrial dynamics in Caenorhabditis elegans impact ultraviolet C radiation- and 6-hydroxydopamine-induced neurodegeneration. International Journal of Molecular Sciences, 2019.

Mitochondrial toxicity. Toxicological Sciences, 2018.

Mitochondrial fusion, fission, and mitochondrial toxicity. Toxicology, 2017.

helpful resources

This page contains a variety of resources, intended especially for members of my own lab but also potentially useful to other scientists or people interested in science.

contact us

Feel free to contact us by the traditional means (or you can always just light the Worm Beacon).