Robert C Smart, PhD
North Carolina State University (NCSU)
Director of Graduate Programs, Department of Environmental and Molecular Toxicology
Director, Molecular Pathways to Pathogenesis in Toxicology NIEHS Training Grant
Director, Center for Human Health and the Environment (CHHE)
William Neal Reynolds Distinguished Professor of Toxicology, Department of Biological Sciences
Dr. Smart’s research involves the identification and characterization of genes/signaling pathways that are determinants of susceptibility to cancer, particularly as it relates to gene-environment interactions. Current research projects include: i) the role of CCAAT/enhancer binding protein transcription factors (C/EBPs) in the regulation of proliferation, differentiation, apoptosis and cancer; ii) the role of C/EBPs in the DNA damage response network/cell cycle checkpoints; iii) the signaling pathways involving oncogenes including Ras and receptor tyrosine kinases that control the transcription activity of C/EBPs; iv) C/EBPb and the tumor cytokine microenvironment in cancer development; and v) use of genetically modified mice to characterize the function of genes in cellular processes involving cell cycle regulation, differentiation, apoptosis, DNA damage response and cancer pathogenesis.
Profile: https://tox.sciences.ncsu.edu/people/robert-c-smart/
Lab Website: https://smartlab.wordpress.ncsu.edu/
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