2017 – 2022: Developmental Exposures: Mechanisms, Outcomes and Remediation


  • Addis SD, Formel SK, Kim YJ, Varner PB, Raudabaugh DB, Lefevre E, Bernik BM, Elango V, Van Bael SA, Pardue JH, Gunsch CK. Alterations of endophytic microbial community function in Spartina alterniflora as a result of crude oil exposure. Biodegradation. 2022 Jan 18:1-2. PMCID: In Process.
  • Berky AJ, Robie E, Chipa SN, Ortiz EJ, Palmer EJ, Rivera NA, Avalos AM, Meyer JN, Hsu-Kim H, Pan WK. Risk of lead exposure from wild game consumption from cross-sectional studies in Madre de Dios, Peru. The Lancet Regional Health – Americas. 2022 Aug 1;12:100266. PMCID: In Process.
  • Bozinovic G, Feng Z, Shea, D, Oleksiak MF. Cardiac physiology and metabolic gene expression during late organogenesis among F. heteroclitus embryo families from crosses between pollution-sensitive and -resistant parents. BMC Ecology and Evolution. 2022 Jan 7: 22(3). PMCID: PMC8739662.
  • Hawkey AB, Evans J, Holloway ZR, Pippen E, Jarrett O, Kenou B, Slotkin TA, Seidler FJ, Levin ED. Developmental exposure to the flame retardant, triphenyl phosphate, causes long‐lasting neurobehavioral and neurochemical dysfunction. Birth Defects Research. 2022. PMCID: In Process.
  • Hawkey AB, Piatos P, Holloway Z, Boyda J, Koburov R, Fleming E, Di Giulio RT, Levin ED. Embryonic exposure to benzo [a] pyrene causes age-dependent behavioral alterations and long-term metabolic dysfunction in zebrafish. Neurotoxicology and Teratology. 2022 Sep 9:107121. PMCID: In Process.
  • Hawkey AB, Pippen E, Kenou B, Holloway Z, Slotkin TA, Seidler FJ, Levin ED. Persistent Neurobehavioral and Neurochemical Anomalies in Middle-Aged Rats after Maternal Diazinon Exposure. Toxicology. 2022 Apr 19:153189. PMCID: In Process.
  • Joglekar R, Grenier C, Hoyo C, Hoffman K, Murphy SK. Maternal Tobacco Smoke Exposure is Associated with Increased DNA Methylation at Human Metastable Epialleles in Infant Cord Blood. Environmental Epigenetics. 2022 Feb 18. PMCID: PMC8962709.
  • King DE, Sparling AC, Lloyd D, Satusky MJ, Martinez M, Grenier C, Bergemann CM, Maguire R, Hoyo C, Meyer JN, Murphy SK. Sex-specific DNA methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes. Epigenetics. 2022 Mar 3: 1-17. PMCID: In Process.
  • Leuthner TC, Benzing L, Kohrn BF, Bergemann CM, Hipp MJ, Hershberger KA, Mello DF, Sokolskyi T, Stevenson K, Merutka IR, Seay SA, Gregory SG, Kennedy SR, Meyer JN. Resistance of mitochondrial DNA to cadmium and Aflatoxin B1 damage-induced germline mutation accumulation in C. elegans. Nucleic Acids Research. 2022 Aug 10: gkac666. PMCID: In Process.
  • Luukinen B, Cohen S, Shapiro-Garza E, Kastleman C, Sherman R, Bradley L. Manage Compost and Soil Contaminated with Broadleaf Herbicides in Residential, School, and Community Gardens. North Carolina State University Extension 2022 April 20. Publication Ag-920.
  • Markovich Z, Hartman JH, Ryde IT, Hershberger KA, Joyce AS, Ferguson PL, Meyer JN. Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans. Current Research in Toxicology. 2022 Aug 2. PMCID: PMC9361317.
  • Mello DF, Bergemann CM, Fisher K, Chitrakar R, Bijwadia SR, Wang Y, Caldwell A, Baugh R, Meyer JN. Rotenone modulates Caenorhabditis elegans immunometabolism and pathogen susceptibility. Frontiers in Immunology.2022 February 22. PMCID: PMC8902048.
  • Mello DF, Maurer LL, Ryde IT, Songr DH, Marinakos SM, Jiang C, Wiesner MR, Hsu-Kim H, Meyer JN. In Vivo Effects of Silver Nanoparticles on Development, Behavior, and Mitochondrial Function are Altered by Genetic Defects in Mitochondrial Dynamics. Environmental Science & Technology. 2022 Jan 4. PMCID: PMC8802983
  • Neal-Walthall N, Ndu U, Rivera Jr NA, Elias DA, Hsu-Kim H. Utility of Diffusive Gradient in Thin-Film Passive Samplers for Predicting Mercury Methylation Potential and Bioaccumulation in Freshwater Wetlands. Environmental Science & Technology. 2022 Jan 19. PMCID: In Process
  • Trevisan R, Ranasinghe P, Jayasundara N, Di Giulio RT. Nanoplastics in Aquatic Environments: Impacts on Aquatic Species and Interactions with Environmental Factors and Pollutants. Toxics. 2022 Jun;10(6):326. PMCID: PMC9230143.
  • Varner PM, Allemann MN, Michener JK, Gunsch CK. The effect of bacterial growth strategies on plasmid transfer and naphthalene degradation for bioremediation. Environmental Technology & Innovation. 2022 Sep 14:102910. PMCID: In Process.
  • Varner PM, Gunsch CK. Complete Genome Sequence of NAH7-Harboring Pseudomonas putida Strain G7. Microbiology Resource Announcements. 2022 Sep 21:e00394-22. PMCID: In Process.
  • Volkoff SJ, Rodriguez DL, Singleton DR, McCumber AW, Aitken MD, Stewart JR, Gunsch CK. Identifying bioaugmentation candidates for bioremediation of polycyclic aromatic hydrocarbons in contaminated estuarine sediment of the Elizabeth River, VA, USA. Applied Microbiology and Biotechnology. 2022 Jan 28:1-3. PMCID: In Process


  • Bijwadia SR, Morton K, Meyer JN. Quantifying Levels of Dopaminergic Neuron Morphological Alteration and Degeneration in Caenorhabditis elegans. Journal of Visual Experiments. 2021 Nov 20(177). PMCID: PMC8826492
  • Bozinovic G, Shea D, Feng Z, Hinton D, Sit T, Oleksiak MF. PAH-pollution effects on sensitive and resistant embryos: Integrating structure and function with gene expression. PloS one. 2021 Apr 6;16(4):e0249432. PMCID: PMC8023486.
  • Hartman JH, Widmayer SJ, Bergemann CM, King DE, Morton KS, Romersi RF, Jameson LE, Leung MCK, Andersen EC, Taubert S, Meyer JN. Xenobiotic metabolism and transport in Caenorhabditis elegansJournal of Toxicology and Environmental Health, Part B. 2021 Feb 22. PMCID: PMC7958427
  • Hawkey AB, Holloway Z, Levin ED. A Behavioral Test Battery to Assess Larval and Adult Zebrafish After Developmental Neurotoxic Exposure. Experimental Neurotoxicology Methods. 2021 (pp. 353-380). PMCID: PMC8826492
  • Hershberger KA, Rooney JP, Turner EA, Donoghue LJ, Bodhicharla R, Maurer LL, Ryde IT, Kim JJ, Joglekar R, Hibshman JD, Smith LL, Dhaval PB, Ilkayeva OR, Hischey MD, Meyer JN. Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans. Redox Biology. 2021 Jul 1;43:102000. PMCID: PMC8134077
  • Holloway Z, Hawkey A, Asrat H, Boinapally N, Levin ED. The Use of Tocofersolan as a Rescue Agent in Larval Zebrafish Exposed to Benzo [a] pyrene in Early Development. NeuroToxicology. 2021 Jul 14. PMCID: PMC8440378
  • Kim YJ, Womble JT, Gunsch CK, Ingram JL. The Gut/Lung Microbiome Axis in Obesity, Asthma, and Bariatric Surgery: A Literature Review. Obesity. 2021 Apr;29(4):636-44. PMCID: PMC7995617
  • King DE, Sparling AC, Joglekar R, Meyer JN, Murphy SK. Direct comparisons of bisulfite pyrosequencing versus targeted bisulfite sequencing. microPublication Biology. 2021;2021. PMCID: PMC8377520
  • Leuthner, TC & Meyer JN. Mitochondrial DNA Mutagenesis: Feature of and Biomarker for Environmental Exposures and Aging. Current Environmental Health Reports. 2021. PMCID: PMC8826492
  • Levin ED. Invited Perspective: Does Developmental Adaptation Pose Risks with Changing Toxicant Exposures? Environmental Health Perspetives. 2021 Aug 12. PMPCID: PMC8360002
  • Pan WK, Weinhouse C, Ortiz EJ, Berky AJ, Fixsen E, Mallipudi A, Feingold BJ, Navio S, Rivera NA, Hsu-Kim H, Miranda JJ. CoNaMad—Cohorte de Nacimiento de Madre de Dios/Madre de Dios Birth Cohort to Study Effects of in-utero Trace Metals Exposure in the Southern Peruvian Amazon. Annals of Global Health. 2021;87(1). PMCID: PMC8300581
  • Patisaul HB, Behl M, Birnbaum LS, Blum A, Diamond ML, Rojello Fernández S, Hogberg HT, Kwiatkowski CF, Page JD, Soehl A, Stapleton HM. Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers. Environmental Health Perspectives. 2021 Oct 6;129(10):105001. PMCID: PMC8493874
  • Redfern LK, Jayasundara N, Singleton DR, Di Giulio RT, Carlson J, Sumner SJ, Gunsch CK. The role of gut microbial community and metabolomic shifts in adaptive resistance of Atlantic killifish (Fundulus heteroclitus) to polycyclic aromatic hydrocarbons. Science of The Total Environment. 2021 Feb 19:145955. PMCID: PMC8294123.
  • Silva RA, Di Giulio RT, Rice CD. The In Vitro Proinflammatory Properties of Water Accommodated Sediment Extracts from a Creosote‐Contaminated US Environmental Protection Agency Superfund Site. Environmental Toxicology and Chemistry. 2021 Jun 1. PMCID: In Process
  • Slotkin TA, Levin ED, Seidler FJ. Paternal Cannabis Exposure Prior to Mating, but Not Δ9-Tetrahydrocannabinol, Elicits Deficits in Dopaminergic Synaptic Activity in the Offspring. Toxicological Sciences. 2021 Sep 30. PMCID: PMC8633960
  • Ulrich JC, Ferguson PL. Development of a sensitive direct injection LC-MS/MS method for the detection of glyphosate and aminomethylphosphonic acid (AMPA) in hard waters. Analytical and Bioanalytical Chemistry. 2021 Apr 12:1-2. PMCID: PMC8154743.
  • Varner PM, Gunsch CK. Properties affecting transfer and expression of degradative plasmids for the purpose of bioremediation. Biodegradation. 2021 May 27:1-5. PMCID: PMC8354580.
  • Wang L, Mello DF, Zucker RM, Rivera NA, Rogers NM, Geitner NK, Boyes WK, Wiesner MR, Hsu-Kim H, Meyer JN. Lack of Detectable Direct Effects of Silver and Silver Nanoparticles on Mitochondria in Mouse Hepatocytes. Environmental Science & Technology. 2021 Aug 4. PMCID: PMC8814061.


  • Brenner RG, Oliveri AN, Sinnott-Armstrong W, Levin ED. Effects of sub-chronic methylphenidate on risk-taking and sociability in zebrafish (Danio rerio). Naunyn-Schmiedeberg’s Archives of Pharmacology. 2020 Feb 6:1-9. PMCID: PMC32025747
  • Chernick M, Burke T, Lieberman N, Brown DR, Di Giulio RT, Hinton DE. Heart development in two populations of Atlantic killifish (Fundulus heteroclitus) following exposure to a polycyclic aromatic hydrocarbon mixture. Ecotoxicology and Environmental Safety. 2020 208:111580. PMCID: PMC7837385
  • Crozier C, Chapman B, Kastleman C, Shapiro-Garza E, Luukinen B, Cohen S, Yang S, Gatiboni L, Bradley L. Managing the Impact of Floodwater Contaminants on Soil and Produce in Residential, Community, and School Vegetable Gardens. North Carolina State University Extension 2020 September 24. Publication Ag-882. 
  • Czaplicki LM, Redfern LK, Cooper EM, Ferguson PL, Vilgalys R, Gunsch CK. Investigating the mycobiome of the Holcomb Creosote Superfund Site. Chemosphere. 2020 Mar 17:126208. PMCID: PMC7242165.
  • Gonzalez-Hunt CP, Luz AL, Ryde IT, Turner EA, Ilkyeva OR, Bhatt DP, Hirschey MD, Meyer JN. Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone. Toxicology. 2020 Nov 11:152630. PMCID: PMC7750303
  • Harris JB, Hartman JH, Luz AL, Wilson JY, Dinyari A, Meyer JN. Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture. Toxicology. 2020 May 1. PMCID: PMC7313633.
  • Hawkey A, Pippen E, White H, Kim J, Greengrove E, Kenou B, Holloway Z, Levin ED. Gestational and perinatal exposure to diazinon causes long-lasting neurobehavioral consequences in the rat. Toxicology. 2020 Jan 15;429:152327. PMCID: PMC6925319.
  • Oliveri A, Glazer L, Mahapatra D, Kullman S, Levin ED. Developmental exposure of zebrafish to vitamin D receptor acting drugs and environmental toxicants disrupts behavioral function. Neurotoxicology and Teratology. 2020 May 27:106902. PMCID: PMC7483728.
  • Oliveri AN, Knuth M, Glazer L, Bailey J, Kullman S, Levin ED. Zebrafish Show Long-term Behavioral Impairments Resulting from Developmental Vitamin D Deficiency. Physiology & Behavior. 2020 Jun 16;113016. PMCID: PMC7737556.
  • Trevisan R, Uzochukwu D, Di Giulio RT. PAH Sorption to Nanoplastics and the Trojan Horse Effect as Drivers of Mitochondrial Toxicity and PAH Localization in Zebrafish. Frontiers in Environmental Science. 2020 Jul 24;8:78. PMCID: PMC8315355.
  • Weinhouse C, Gallis JA, Ortiz E, Berky AJ, Morales AM, Diringer SE, Harrington J, Bullins P, Rogers L, Hare-Grogg J, Hsu-Kim H. A population-based mercury exposure assessment near an artisanal and small-scale gold mining site in the Peruvian Amazon. Journal of Exposure Science & Environmental Epidemiology. 2020 May 28:1-1. PMCID: PMC8281380.
  • Zhang J, Hartman JH, Chen C, Yang S, Li Q, Tian Z, Huang PH, Wang L, Meyer JN, Huang TJ. Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics. Lab on a Chip. 2020. PMCID: PMC7600273

Return to top


  • Bachman H, Fu H, Huang PH, Tian Z, Embry-Seckler J, Rufo J, Xie Z, Hartman JH, Zhao S, Yang S, Meyer JN. Open source acoustofluidics. Lab on a Chip. 2019; (19) 2404-2414. PMCID: PMC6934416.
  • Budarz JF, Cooper EM, Gardner C, Hodzic E, Ferguson PL, Gunsch CK, Wiesner MR. Chlorpyrifos degradation via photoreactive TiO2 nanoparticles: assessing the impact of a multi-component degradation scenario. Journal of Hazardous Materials. 2019 Jun 15;372:61-8. PMCID: PMC5995634.
  • Cooper EM, Rushing R, Hoffman K, Phillips AL, Hammel SC, Zylka MJ, Stapleton HM. Strobilurin fungicides in house dust: is wallboard a source? Journal of Exposure Science & Environmental Epidemiology. 2019 Oct 21:1-6. PMCID: PMC7044059.
  • Dreier DA, Mello D, Meyer J, Martyniuk CJ. Linking mitochondrial dysfunction to organismal and population health in context of environmental pollutants: Progress and considerations for mitochondrial adverse outcome pathways. Environmental Toxicology and Chemistry. PMCID: PMC6961808.
  • Hartman JH, Gonzalez-Hunt C, Hall SM, Ryde IT, Caldwell KA, Caldwell GA, Meyer JN. Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation-and 6-hydroxydopamine-Induced Neurodegeneration. International journal of molecular sciences. 2019 Jan 20 (13):3202. PMCID: PMC6651461.
  • Hershberger KA, Leuthner TC, Waters TA, Meyer JN. Caenorhabditis elegans strain sensitivity to sodium arsenite exposure is varied based on age and outcome measured. 2019 Oct 22. microPublication Biology. PMCID: PMC7252313.
  • Lefevre E, Redfern L, Cooper EM, Stapleton HM, Gunsch CK. Acetate promotes microbial reductive debromination of tetrabromobisphenol A during the startup phase of anaerobic wastewater sludge bioreactors. Science of The Total Environment. 2019 Mar 15; 656:959-68. PMCID: PMC6481660.
  • Leung MC, Meyer JN. Mitochondria as a target of organophosphate and carbamate pesticides: Revisiting common mechanisms of action with new approach methodologies. Reproductive Toxicology. 2019 Oct 1;89:83-92. PMCID: PMC6917040.
  • Lindberg CD, Di Giulio RT. Polycyclic Aromatic Hydrocarbon and Hypoxia Exposures Result in Mitochondrial Dysfunction in Zebrafish. Aquatic Toxicology. 2019 Sep 13:105298. PMCID: PMC6917040.
  • Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N. Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span. Aging. 2019 Aug. PMCID: PMC6738431
  • Redfern, L.K., Gardner, C.M., Hodzic, E., Ferguson, P.L., Hsu-Kim, H. and Gunsch, C.K., 2019. A new framework for approaching precision bioremediation of PAH contaminated soils. Journal of Hazardous Materials, p.120859. PMCID: PMC6833951.
  • Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. Perinatal Diazinon Exposure Compromises the Development of Acetylcholine and Serotonin Systems. Toxicology. 2019 Jun 25:152240. PMCID: PMC6689134.
  • Smith LL, Ryde IT, Hartman JH, Romersi RF, Markovich Z, Meyer JN. Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans. Neurotoxicology. 2019 Sep 1;74:209-20. PMCID: PMC6751008.
  • Trevisan R, Voy C, Chen S, Di Giulio RT. Nanoplastics decrease the toxicity of a complex PAH mixture but impair mitochondrial energy production in developing zebrafish. Environmental Science & Technology. 2019 Jun 24. PMCID: PMC6660138.
  • Volkoff SJ, Osterberg JS, Jayasundara N, Cooper E, Hsu-Kim H, Rogers L, Gehrke GE, Jayaraman S, Di Giulio RT. Embryonic Fundulus heteroclitus responses to sediment extracts from differentially contaminated sites in the Elizabeth River, VA. Ecotoxicology. 2019 Oct 16:1-0. PMCID: PMC7768634
  • Zhang J, Yang S, Chen C, Hartman JH, Huang PH, Wang L, Tian Z, Zhang P, Faulkenberry D, Meyer JN, Huang TJ. Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans. Lab on a Chip. 2019;19(6):984-92. PMCID: PMC6659422.

Return to top


  • Berky AJ, Ryde IT, Feingold B, Ortiz EJ, Wyatt LH, Weinhouse C, Hsu‐Kim H, Meyer JN, Pan WK. Predictors of mitochondrial DNA copy number and damage in a mercury‐exposed rural Peruvian population near artisanal and small‐scale gold mining: An exploratory study. Environmental and Molecular Mutagenesis. PMCID: PMC6452630.
  • Cothren SD, Meyer JN, Hartman, JH. Blinded Visual Scoring of Images Using the Freely-available Software Blinder. Bio-protocol 2018 Dec 5; 8(23): e3103. PMCID: PMC6370323.
  • Czaplicki LM, Dharia M, Cooper EM, Ferguson PL, Gunsch CK. Evaluating the mycostimulation potential of select carbon amendments for the degradation of a model PAH by an ascomycete strain enriched from a superfund site. Biodegradation. 2018 Jul 13:1-9. PMCID: PMC6330244.
  • Glazer L, Hawkey AB, Wells CN, Drastal M, Odamah KA, Behl M, Levin ED. Developmental exposure to low concentrations of organophosphate flame retardants causes life-long behavioral alterations in zebrafish. Toxicological Sciences. 2018 Jun 29;165(2):487-98. PMCID: PMC6154272.
  • Glazer L, Wells CN, Drastal M, Odamah KA, Galat RE, Behl M, Levin ED. Developmental exposure to low concentrations of two brominated flame retardants, BDE-47 and BDE-99, causes life-long behavioral alterations in zebrafish. Neurotoxicology. 2018 May 1;66:221-32. PMCID: PMC5858967
  • Hartman JH, Smith LL, Gordon KL, Laranjeiro R, Driscoll M, Sherwood DR, Meyer JN. Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity. Scientific reports. 2018 May 29;8(1):8359. PMCID: PMC5974391.
  • Hibshman JD, Leuthner TC, Shoben C, Mello DF, Sherwood DR, Meyer JN, Baugh LR. Non-selective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans. American Journal of Physiology-Cell Physiology. 2018 Aug 22. PMCID: PMC6336938.
  • Kassotis CD, Kollitz EM, Ferguson PL, Stapleton HM. Nonionic ethoxylated surfactants induce adipogenesis in 3T3-L1 cells. Toxicol Sci. 2018. PMCID:  PMC6256959.
  • Kollitz EM, De Carbonnel L, Stapleton HM, Ferguson PL. The Affinity of Brominated Phenolic Compounds for Human and Zebrafish Thyroid Receptor β: Influence of Chemical Structure. Toxicological Sciences. 2018 Feb 02. PMCID:  PMC5920296.
  • Kollitz E, Kassotis CD, Hoffman K, Ferguson PL, Sosa JA, Stapleton HM. Chemical mixtures isolated from house dust disrupt thyroid receptor β (TRβ) signaling. Environmental science & technology. 2018 Sep 13. PMCID: PMC6433547.
  • Lefèvre E, Bossa N, Gardner CM, Gehrke GE, Cooper EM, Stapleton HM, Hsu-Kim H, Gunsch CK. Biochar and activated carbon act as promising amendments for promoting the microbial debromination of tetrabromobisphenol A. Water Research. 2018 January 1. PMCID: PMC5796758.
  • Luz AL, Kassotis CD, Stapleton HM, Meyer JN. The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARγ activation, in 3T3-L1 cells. Toxicology. 2018 January. PMCID: PMC5726929.
  • Massarsky A, Abdel A, Glazer L, Levin ED, Di Giulio RT. Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio). Neurotoxicology. 2018. PMCID: PMC7008519.
  • Massarksy A,  Kozal JS, Di Giulio RT. Glutathione and zebrafish: old assays to address a current issue. Chemosphere. 2016 Nov 9; 168:707-715. PMCID: PMC5182135.
  • Meyer JN, Hartman JH, Mello DF. Mitochondrial toxicity. Toxicological Sciences. 2018 Jan 11;162(1):15-23. PMCID: PMC5837373.
  • Oliveri AN, Levin ED. Dopamine D1 and D2 Receptor Antagonism During Development Alters Later Behavior in Zebrafish. Behavioural brain research. 2018 Aug 30. PMCID: PMC6192051.
  • Oliveri AN, Ortiz E, Levin ED. Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae. Neurotoxicology and teratology. 2018 May 1;67:25-30. PMCID: PMC5970957.
  • Osterberg JS, Cammen KM, Schultz TF, Clark BW, Di Giulio RT. Genome-wide scan reveals signatures of selection related to pollution adaptation in non-model estuarine Atlantic killifish (Fundulus heteroclitus). Aquatic Toxicology. 2018 Jul 1;200:73-82. PMCID: PMC6957077.
  • Pitt JA, Kozal JS, Jayasundara N, Massarsky A, Trevisan R, Geitner N, Di Giulio RT. Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio). Aquatic Toxicology. 2018 January; 194:185-194. PMCID: PMC6959514.
  • Pitt JA, Trevisan R, Massarsky A, Kozal JS, Levin ED, Di Giulio RT. Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene. Science of The Total Environment. 2018 Dec 1;643:324-34. PMCID: PMC7012458.
  • Sanders LH, Rouanet JP, Howlett EH, Leuthner TC, Rooney JP, Greenamyre JT, Meyer JN. Newly Revised Quantitative PCR‐Based Assay for Mitochondrial and Nuclear DNA Damage. Current Protocols in Toxicology. 2018 May  18;e50. PMCID: PMC6060631.
  • Slotkin TA, Ko A, Seidler FJ. Does Growth Impairment Underlie the Adverse Effects of Dexamethasone on Development of Noradrenergic Systems?. Toxicology. 2018 Jun 20. PMCID: PMC6150779.
  • Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo [a] pyrene: Effects on Cholinergic and Serotonergic Systems. Toxicological Sciences. 2018 Sep 22. PMCID: PMC6681680.
  • Slotkin TA, Skavicus S, Seidler FJ. Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together. Toxicology. 2018 May 1;400:57-64. PMCID: PMC5903951.
  • Wang F, Fang M, Hinton DE, Chernick H, Jia S, Zhang Y, Xie L, Dong W, Dong W. Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47. Chemosphere. 2018 May; 198: 342-350. PMCID: PMC7006228
  • Watson ATD, Nordberg RC, Loboa EG, Kullman SW. Evidence for aryl hydrocarbon receptor-mediated inhibition of osteoblast differentiation in human mesenchymal stem cells. Toxicological Sciences. 2018 Sep 7. PMCID: PMC6317429.
  • Weinhouse C, Truong L, Meyer JN, Allard P. Caenorhabditis elegans as an emerging model system in environmental epigenetics. Environmental and Molecular Mutagenesis. 2018 Aug. PMCID: PMC6113102.

Return to top

2011 – 2017: Developmental Toxicants: Mechanisms, Consequences, and Remediation


  • Abreu-Villaça Y and ED Levin. Developmental neurotoxicity of succeeding generations of insecticides. Environment International. 2017 Feb; 99:55-77. PMCID: PMC5285268.
  • Bossa N, Carpenter AW, Kumar N, de Lannoy C, Wiesner MR. Cellulose nanocrystal zero-valent iron nanocomposites for groundwater remediation. Environ Sci Nano. 2017; 4:1294-1303. PMCID: PMC5929147
  • Brown DR, Thompson J, Chernick M, Hinton DE, Di Giulio RT. Later Life Swimming Performance and Persistent Heart Damage Following Subteratogenic PAH Mixture Exposure in the Atlantic Killifish (Fundulus heteroclitus). Environmental Toxicology and Chemistry. 2017 Jun 6. PMCID: PMC5942201.
  • Budarz, JF, Cooper EM, Gardner C, Hodzic E, Ferguson PL, Gunsch CK, Wiesner MR (in press). Chlorpyrifos degradation via photo reactive TiO2 nanoparticles: Assessing the impact of a multi-component degradation scenario. Journal of Hazardous Materials. 2017 December. PMCID: PMC5995634.
  • Hartman JH, Kozal JS, Di Giulio RT, Meyer JN. Zebrafish Have an Ethanol-Inducible Hepatic 4-Nitrophenol Hydroxylase that is Not CYP2E1-like. Environmental Toxicology and Pharmacology. 2017 Jul 10. PMCID: PMC5563387.
  • Jayasundara N, Fernando PW, Osterberg JS, Cammen KM, Schultz TF, Di Giulio RT. Cost of Tolerance: Physiological Consequences of Evolved Resistance to Inhabit a Polluted Environment in Teleost Fish Fundulus heteroclitus. Environmental Science and Technology. 2017 Jul 6. PMCID: PMC5745795.
  • Levin ED. Neurodevelopmental Toxicity of Tobacco Smoke and Nicotine, in 41st Anniversary Annual Meeting of the Developmental Neurotoxicology Society Held in Conjunction with the 57th Annual Meeting of the Teratology Society Grand Hyatt Hotel, Denver CO June 2428, 2017. Neurotoxicol Teratol 2017 Jun; 61:153. doi:10.1016/
  • Lindberg CD, Jayasundara N, Kozal JS, Leuthner T, Di Giulio RT. Resistance to polycyclic aromatic hydrocarbon toxicity and associated bioenergetic consequences in a population of Fundulus heteroclitus. Ecotoxicology. 2017 Feb 17. PMCID: PMC5398948
  • Luz AL, Godebo TR, Smith LL, Leuthner TC, Maurer LL, Meyer JN. Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability. Toxicology. 2017 Jun 8. PMCID: PMC5535741
  • Meyer JN, Leuthner TC, Luz AL. Mitochondrial fusion, fission, and mitochondrial toxicity. Toxicology. 2017 November. PMCID: PMC5681418.
  • Micic V, Schmid D, Bossa N, Gondikas A, Velimirovic M, von der Kammer F, Wiesner MR, Hofmann T. Impact of sodium humate coating on collector surfaces on deposition of polymer-coated nano-iron particles. Environmental Science & Technology. 2017 Jul 6. PMCID: PMC5802353
  • Mu J, Chernick M, Dong W, Di Giulio RT, Hinton DE. Early life co-exposures to a real-world PAH mixture and hypoxia result in later life and next generation consequences in medaka (Oryzias latipes). Aquatic Toxicology. Published online 2017 Jun 27. PMCID: PMC5584607.
  • Raftery TD, Jayasundara N, and Di Giulio RT. A bioenergetics assay for studying the effects of environmental stressors on mitochondrial function in vivo in zebrafish larvae. Comparative Biochemistry and Physiology, Part C: Toxicology and Pharmacology. 2017; 192:23-32. PMCID: PMC5218841.
  • Slotkin TA, Skavicus S, Card J, Di Giulio RT, and Seidler FJ. In vitro models reveal differences in the developmental neurotoxicity of an environmental polycyclic aromatic hydrocarbon mixture compared to benzo[a]pyrene: neuronotypic PC12 cells and embryonic neural stem cells. 2017; Toxicology 377:49–56. PMCID: PMC5250555.
  • Slotkin TA, Skavicus S, Seidler FJ. Diazinon And Parathion Diverge In Their Effects On Development Of Noradrenergic Systems. 2017 Feb. Brain Res. Bull. doi: 10.1016/j.brainresbull.2017.02.004. [ePub ahead of print]. PMCID: PMC5406256
  • Slotkin TA, Skavicus S, Stapleton HM, Seidler FJ. Brominated and Organophosphate Flame Retardants Target Different Neurodevelopmental Stages, Characterized with Embryonic Neural Stem Cells and Neuronotypic PC12 Cells. Toxicology. 2017 Aug 26. PMCID: PMC5633518.

Return to top


  • Bailey JM, AN Oliveri, N Karbhari, RA Brooks, AJ De La Rocha, S Janardhan and ED Levin. Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish. NeuroToxicology. 2016; 52:23-33. PMCID: PMC4753107.
  • Brown DR, Bailey J, Oliveri A, Levin ED, and Di Giulio RT. Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish. Neurotoxicology and Teratology. 2016 Jan-Feb; 53: 55-63. PMCID: PMC4803068.
  • Brown DR, Clark BW, Garner LVT, Di Giulio RT. Embryonic cardiotoxicity of weak aryl hydrocarbon receptor agonists and CYP1A inhibitor fluoranthene in the Atlantic killifish (Fundulus heteroclitus). Comp Biochem and Physiol C Toxicol Pharmacol. 2016 May 20; 188:45-51. PMCID: PMC Journal – In Process.
  • Carignan CC, Fang M, Stapleton HM, Heiger-Bernays W, McClean MD, Webster TF. Urinary biomarkers of flame retardant exposure among collegiate US gymnasts. Environ. Int. 2016 Jul 6. PMCID: PMC4980234 
  • Chernick M, Ware M, Albright E, Kwok KWH, Dong W, Zheng N, Hinton DE. Parental dietary seleno-L-methionine exposure and resultant offspring developmental toxicity. Aquatic Toxicology. 2016 Jan; 170: 187-98. PMCID: PMC4698014.
  • Cooper EM, Kroeger G, Davis Warnell K, Clark C, Ferguson PL, Stapleton HM. Results from Screening Polyurethane Foam Based Consumer Products for Flame Retardant Chemicals: Assessing Impacts on the Change in the Furniture Flammability Standards. Environmental Science & Technology. 2016 Aug 23. PMCID: PMC5052662.
  • Czaplicki LN, Cooper EM, Ferguson PL, Stapleton HM, Vilgalys R, Gunsch C. 2016. A New Perspective on Sustainable Soil Remediation: Case Study Suggests Novel Fungal Genera Could Facilitate in situ Biodegradation of Hazardous Contaminants. Remediation. 26:59-72. doi:10.1002/rem.21458 PMCID: PMC5130160
  • Czaplicki LM, Gunsch CK. A Reflection on Molecular Approaches Influencing State-of-the-Art Bioremediation Design: Culturing to Microbial Community Fingerprinting to Omics. Oct. 2016; Journal of Environmental Engineering. NIHMSID: 847435.
  • González-Hunt CP, Rooney JP, Joglekar R, Anbalagan C, Ryde IT, Meyer JN. 2016. PCR-based analysis of mitochondrial DNA copy number, mitochondrial DNA damage, and nuclear DNA damage. Current Protocols in Toxicology. 2016 Feb 1; 67:20.11.1-20.11.25. PMCID: PMC4928199.
  • Lefevre E, Bossa N, Wiesner MR, Gunsch C. 2016. A review of the environmental implications of in situ remediation by nanoscale zero valent iron (nZVI): Behavior, transport and impacts on microbial communities. The Science of the Total Environment. doi:10.1016/j.scitotenv.2016.02.003 PMCID: PMC5217753
  • Lefèvre E, Cooper E, Stapleton HM, Gunsch CK. Characterization and adaptation of anaerobic sludge microbial communities exposed to tetrabromobisphenol A. PloS ONE. 2016 Jul 27;11(7):e0157622. PMCID: PMC4963083
  • Levin ED. Crumbling infrastructure and learning impairment. Environ. Health Perspect. 2016 May 1;124(5):A79. PMCID: PMC4858389.
  • Luz AL, Godebo T, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN. Arsenite uncouples mitochondrial respiration and induces a Warburg-like effect in Caenorhabditis elegans. Toxicol. Sci. 2016 Aug; 152(2): 349-62. PMCID: PMC4960910.
  • Luz AL, Lagido C, Hirschey, Meyer JN. In vivo determination of mitochondrial function using luciferase-expressing Caenorhabditis elegans: contribution of oxidative phosphorylation, glycolysis, and fatty acid oxidation to toxicant-induced dysfunction. Curr. Protoc Toxicol. 2016 Aug 1; 69: 25.8.1-25.8.22. PMCID: PMC5002950 [Available on 2017-08-01].

  • Luz AL, Smith LL, Rooney JP, and Meyer JN. Seahorse Xfe 24 extracellular flux analyzer-based analysis of cellular respiration in Caenorhabditis elegans. Curr. Protoc in Toxicol. 2015 Nov 2; 66:25.7.1-15. PMCID: PMC4632645.
  • Macaulay LJ, Bailey JM, Levin ED and Stapleton HM. Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior. Neurotoxicology and Teratology, 52:119-126, 2015. PMCID: PMC4644107.
  • Macaulay LJ, Chen A, Rock K, Dishaw L, Dong W, Hinton DE, Stapleton HM. Developmental toxicity of the PBDE metabolite 6-OH-BDE-47 in zebrafish and the potential role of thyroid receptor β. Aquatic Toxicol. 2015 Nov; 168: 38-47. PMCID: PMC4618599.
  • Macaulay LJ, Chernick M, Chen A, Hinton DE, Bailey JM, Kullman SW, Levin ED, Stapleton HM. Exposure to PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development. Environ Toxicol Chem. Epub 2016 Aug. PMID: 27329031 PMCID: PMC Journal – In Process.
  • Petro A, HG Sexton, C Miranda, A Rastogi and JH Freedman and ED Levin. Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice. BMC Pharmacology and Toxicology. 2016; 17:55. PMCID: PMC5090947.
  • Redfern LK, Gunsch CK. Endophytic phytoaugmentation: treating wastewater and runoff through augmented phytoremediation. Ind Biotechnol. 2016 Apr 1; 12(2): 83-90. PMCID: PMC4835827.
  • Riley AK, Chernick M, Brown DR, Hinton DE, Di Giulio RT. Hepatic responses of juvenile Fundulus heteroclitus from pollution-adapted and nonadapted populations exposed to Elizabeth River sediment extract. Toxicol Pathol. 2016 Jul; 44(5): 738-48. PMCID: PMC4912431.
  • Santa-González GA, Gómez-Molina A, Arcos-Burgos M, Meyer JN, Camargo M. Distinct adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. Redox Biol. 2016 Jul 21; 9: 124-133. PMCID: PMC4971155.
  • Shan D, Deng S, Zhao T, Wang B, Wang Y, Huang J, Yu G, Winglee J, Wiesner MR. 2016. Preparation of ultrafine magnetic biochar and activated carbon for pharmaceutical adsorption and subsequent degradation by ball milling. Journal of Hazardous Materials. 305:156-163. doi:10.1016/j.jhazmat.2015.11.047 PMID:26685062
  • Slotkin TA, Skavicus S, Card J, Levin ED and Seidler FJ (2016) Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes. Toxicology 372:42-51. PMC5137195
  • Van Houten B, Hunter SE, Meyer JN. Mitochondrial DNA damage induced autophagy, cell death, and disease. Front Biosci (Landmark Ed.). 2016 Jan 1; 21: 42-54. PMCID: PMC4750375.

Return to top



  • Bailey JM, Oliveri AN, Levin ED. Pharmacological analyses of learning and memory in zebrafish (Danio rerio). Pharmacol. Biochem Behav. 2015 Dec; 139 Pt B:103-111. PMCID: PMC4573775.
  • Bailey JM, Oliveri AN, Zhang C, Frazier JM, Mackinnon S, Cole GJ, Levin ED. Long-term behavioral impairment following acute embryonic ethanol exposure in zebrafish. Neurotoxicol Teratol. 2015 Mar-Apr;48:1-8. Epub 2015 Jan 16. PMCID: PMC4363207.
  • Brown DR, Clark BW, Garner LVT, and Di Giulio RT. Zebrafish cardiotoxicity: the effects ofCYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists. Environmental Science and Pollution Research International. 2015 Jun; 22(11) :8329–8338. PMCID: PMC4442063.
  • Carpenter AW, de Lannoy CF, Wiesner MR. Cellulose nanomaterials in water treatment technologies. Environmental science & technology. 2015 May 5; 49(9): 5277-5287. PMCID: PMC4544834.
  • Carpenter AW, Laughton SN, Wiesner MR. Enhanced biogas production from nanoscale zero valent iron-amended anaerobic bioreactors. Environmental Engineering Science. 2015 Aug 1; 32(8): 647-655. PMCID: PMC4545702.
  • Carvan MJ, Di Giulio RT. Oxidative stress responses in aquatic and marine fishes. In: Roberts SM, Kehrer J, Klotz L-O, editors. Studies on Experimental Toxicology and Pharmacology. New York: Springer; 2015. p. 481-493.
  • Crosby EB, Bailey JM, Oliveri AN, Levin ED. Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish. Neurotoxicology and Teratology. 2015 May-Jun; 49:81-90. PMCID: PMC4458463.
  • Di Giulio RT, Clark BW. The Elizabeth River story: a case study in evolutionary toxicology. Journal of Toxicology and Environmental Health, Part B – Critical Reviews. 2015; 18(6):259-298. (DOI: 10.1080/15320383.2015.1074841). PMCID: PMC4733656.
  • Jayasundara N, Kozal JS, Arnold MC, Chan SSL, and Di Giulio RT. High-throughput tissue bioenergetics analysis reveals identical metabolic allometric scaling for teleost hearts and whole organisms. PLoS ONE. 2015 Sep 14; 10(9): e0137710. (DOI:10.1371/journal.pone.0137710). PMCID: PMC4569437.
  • Jayasundara N, Van Tiem L, Meyer JN, Erwin K, and Di Giulio RT. AHR2 mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs. Toxicological Sciences. 2015 Feb 1; 143(2): 469-481. PMCID: PMC4306723.
  • Luz AL, Rooney JP, Kubik LL, González-Hunt CP, Song DH, and Meyer JN. Mitochondrial morphology and fundamental parameters of the mitochondrial respiratory chain are altered in Caenorhabditis elegans deficient in mitochondrial dynamics and homeostasis processes. PLoS ONE. 2015 Jun 24; 10(6):e0130940. PMCID: PMC4480853.
  • Macaulay LJ, Chen A, Rock KD, Dishaw LV, Dong W, Hinton DE, Stapleton HM. Developmental toxicity of the PBDE metabolite 6-OH-BDE-47 in zebrafish and the potential role of thyroid receptor β. Aquatic Toxicology. 2015 Nov; 168:38-47. PMCID: PMC4618599.
  • Massarsky AN, Jayasundara N, Bailey JM, Levin ED, Prasad GL, and Di Giulio RT. Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine. Neurotoxicology and Teratology. 2015 Sep-Oct; 51:77-88. PMCID: PMC4821439.
  • Oliveri AN, JM Bailey and ED Levin. Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish.  Neurotoxicology and Teratology, 52:220-227, 2015; PMCID: PMC4769864.
  • Robey RB, Weisz J, Kuemmerle N, Salzberg AC, Berg A, Brown DG, Kubik L, Palorini R, Al-Mulla F, Al-Temaimi R, Colacci A, Mondello C, Raju J, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Hamid RA, Williams GP, Lowe L, Meyer J, Martin FL, Bisson WH, Chiaradonna F, and Ryan EP. Metabolic reprogramming and dysregulated metabolism: Cause, consequence, and/or enabler of environmental carcinogenesis? Carcinogenesis. 2015 Jun; 36 (S1): S203-S231. PMCID: PMC4565609.
  • Rooney JP, Ryde IT, Saunders LH, Howlett EH, Colton MD, Germ KE, Mayer GD, Greenamyre JT, Meyer JN. PCR based determination of mitochondrial DNA copy number in multiple species. Methods in Molecular Biology. 2015; 1241: 23-38. PMCID: PMC4312664.
  • Shan D, Deng S, Zhao T, Wang B, Wang Y, Huang J, Yu G, Winglee J, Wiesner MR. 2016. Preparation of ultrafine magnetic biochar and activated carbon for pharmaceutical adsorption and subsequent degradation by ball milling. Journal of Hazardous Materials. 305:156-163. doi:10.1016/j.jhazmat.2015.11.047 PMID:26685062
  • Slotkin TA, Seidler FJ. Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just “different?”. Brain Res. Bull. 2015 Jan; 110:54-67. PMCID: PMC4297693.
  • Slotkin TA, Skavicus S, Levin ED, Seidler FJ. Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition. Brain research bulletin. 2015 Feb; 111: 84-96. PMCID: PMC4324014.
  • Slotkin TA, Skavicus S, Seidler FJ. Prenatal drug exposures sensitize noradrenergic circuits to subsequent disruption by chlorpyrifos. Toxicology. 2015 Dec 2; 338: 8-16. PMCID: PMC4658258.
  • Turolla, A., Piazzoli, A., Budarz, J. F., Wiesner, M. R. & Antonelli, M. Experimental measurement and modelling of reactive species generation in TiO2 nanoparticle photocatalysis. Chemical Engineering Journal 271, 260-268, doi:10.1016/j.cej.2015.03.004 (2015). PMCID: PMC5119892.

Return to top


  • Clark BW, Bone AJ, Di Giulio RT. Resistance to aryl-hydrocarbon-induced cardiac teratogenesis in F1 and F2 embryos of PAH-adapted Fundulus heteroclitus is strongly inherited despite reduced recalcitrance to induction of the AHR pathway. Environmental Science and Pollution Research 2014 Dec;21(24):13898-908. PMCID: PMC4074458
  • Colton MD, Kwok KWH, Brandon JA, Warren IH, Ryde IT, Cooper EM, Hinton DE, Rittschof D, Meyer JN. Developmental toxicity and DNA damage from exposure to parking lot runoff water in the Japanese medaka (Oryzias latipes). 2014; Marine Environmental Research 99: 117-124. PMCID: PMC4309550.
  • Dong W, Macaulay LJ, Kwok WH, Hinton DE, Ferguson PL, Stapleton HM. The PBDE Metabolite 6–OH–BDE–47 affects melanin pigmentation and THRb mRNA expression in the eye of zebrafish embryos, endocrine disruptors. Endocr Disruptors (Austin). 2014; 2(1).DOI: 10.4161/23273739.2014.969072. PMCID: PMC4354867.
  • Fang M, Getzinger GJ, Cooper EM, Clark BW, Garner LV, Di Giulio RT, Ferguson PL, Stapleton HM. Effect‐directed analysis of Elizabeth River porewater: Developmental toxicity in zebrafish (Danio rerio). Environmental Toxicology and Chemistry. 2014 Dec 1;33(12):2767-74. PMCID: PMC4393830.
  • Jayasundara N, Van Tiem Garner L, Meyer JN, Erwin KN, Di Giulio RT. AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs. Toxicol Sci. 2015 Feb;143(2):469-81. doi: 10.1093/toxsci/kfu245. Epub 2014 Nov 19. PMCID: PMC4306723.
  • Levin ED, Cauley M, Johnson J, Cooper EM, Stapleton HM, Ferguson PL, Seidler FJ, Slotkin TA. Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor. Neurotoxicol. Teratol. 2014 Jan-Feb; 41:35-42. PMCID: PMC3943881.
  • Levin ED. Developmental toxicology and children’s environmental health. In: Textbook of Children’s
    Environmental Health. PJ Landrigan and RA Etzel (eds.), Oxford University Press, New York, 83-88, 2014.
  • Shaughnessy DT, McAllister KA, Worth L Jr, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley T, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environmental Health Perspectives. 2014 Dec; 122:1271-1278. PMCID: PMC4256704.
  • Slotkin TA, Card J, Seidler FJ. Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways. Brain Res. Bull. 2014 Jan; 100:44-54. PMCID: PMC3891922.
  • Slotkin TA, Card J, Seidler FJ. Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function. Brain Res. Bull. 2014 Mar; 102:1-8. PMCID: PMC3972282.

Return to top

  • Bess AS, Ryde IT, Hinton DE, Meyer JN. UVC-induced mitochondrial degradation via autophagycorrelates with mtDNA damage removal in primary human fibroblasts. Journal of Biochemical and Molecular Toxicology. 2013 Jan; 27: 28-41. PMCID: PMC3640456.
  • Bozinovic G, Sit TL, Di Giulio RT, Wills LP, and Oleksiak MF. Genomic and physiological responses to strong selective pressure during late organogenesis: few gene expression changes found despite striking morphological differences. BMC Genomics. 2013 Nov 11; 14:779. DOI: 10.1186/10.1186/1471-2164-14-779. PMCID: PMC3835409.
  • Clark BW, Cooper EM, Stapleton HM, Di Giulio RT. Compound- and mixture-specific differences in resistance to polycyclic aromatic hydrocarbons and PCB-126 among Fundulus heteroclitus subpopulations throughout the Elizabeth River estuary (Virginia, USA). Environ Sci Technol. 2013 Sep 17;47(18):10556-66. PMCID: PMC4079253.
  • Dong W, Macaulay LJ, Kwok KWH, Hinton DE, Stapleton HM. Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: A tool for examining OH-BDE toxicity to early life stages. 2013 May 15; Aquat. Toxicol. 132-133 (190-199). PMCID: PMC3642849.
  • Garner, LVT, Brown DR, Di Giulio RT. The role of zebrafish (Danio rerio) AHR1 isoforms in PAH- and PCB-126-induced toxicity. Aquatic Toxicology. 2013 Oct 15; 142/143:336-346. PMCID: PMC3837554.
  • Meyer JN, Leung MCK, Rooney JP, Sendoel A, Hengartner MO, Kisby GE, Bess AS. Mitochondria as a target of environmental toxicants. Toxicological Sciences. 2013 Jul; 134: 1-17. PMCID: PMC3693132.
  • Slotkin TA, Card J, Infante A, Seidler FJ. Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: implications for vulnerability after pharmacotherapy for preterm labor. Neurotoxicol. Teratol. 2013 May-Jun; 37:1-12. PMCID: PMC3669256.
  • Slotkin TA, Card J, Seidler FJ. Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells. Environ. Health Perspect. 2013 Jul; 121:825-831. PMCID: PMC3702011.
  • Slotkin TA, Card J, Infante A, Seidler FJ. BDE99 (2,2′,4,4′,5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells. Neurotoxicol. Teratol. 2013 May-Jun; 37:13-17. PMCID: PMC3669237.
  • Slotkin TA, Cooper EM, Stapleton HM, Seidler FJ. Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos? Environ. Toxicol. Pharmacol. 2013 Sep; 36:284-287. PMCID: PMC3745805.

Return to top

  • Clark BW, Di Giulio RT. Fundulus heteroclitus adapted to PAHs are cross-resistant to multiple insecticides. Ecotoxicology. 2012 Mar; 21(2):465-474. doi:10.1007/s10646-011-0807-x. PMCID: PMC3278525.
  • Van Tiem LA, Di Giulio RT. Glutathione s-transferase pi class 2 (GSTp2) protects against the cardiac deformities caused by exposure to PAHs but not PCB-126 in zebrafish embryos. Comparative Biochemistry and Physiology. 2012 May; 155(4): 573-9. doi:10.1016/j.cbpc.2012.01.007 PMCID: PMC3311777.

Return to top

2006 – 2011: Superfund Chemicals’ Impact on Reproduction and Development


  • Ela, Wendell P., David L. Sedlak, M. Barlaz, Heather F. Henry, D. Muir, D. Swackhamer, E. Weber, Robert G. Arnold, P. Lee Ferguson, Jennifer A. Field, Edward T. Furlong, John P. Giesy, Rolf Ulrich Halden, T. Henry, R. Hites, Keri C. Hornbuckle, P. Howard, Richard G. Luthy, A. Meyer, A. Eduardo Saez, F. vom Saal, Christopher Vulpe, and Mark R. Wiesner. 2011. Workshop Summary: Toward Identifying the Next Generation of Superfund and Hazardous Waste Site Contaminants . PMCID: PMC3018501.
  • Fleming, Carrie R. and Richard T. Di Giulio. 2011. The role of CYP1A inhibition in the embryotoxic interactions between hypoxia and polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures in zebrafish (Danio rerio). Ecotoxicology. 20:1300-1314. doi:10.1007/s10646-011-0686-1. PMCID: PMC4018733.
  • Jung, Dawoon, Cole W. Matson, Leonard B. Collins, Geoff Laban, Heather Stapleton, John W. Bickham, James A. Swenberg, and Richard T. Di Giulio. 2011. Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia. Ecotoxicology. 20:1890-1899. doi:10.1007/s10646-011-0727-9. PMCID: PMC3203518.
  • Levin, Edward D. 2011. Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development. Reviews in the Neurosciences. 22:75-84. PMCID: PMC4691346.
  • Levin, Edward D., Ann Petro, Sue Donerly, Elwood Linney, Damiyon Sledge, and Stephanie Roach. 2011. Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish. Neurotoxicology and Teratology. 33:668-673. doi:10.1016/ PMCID: PMC3225500.
  • Powers, C., Edward D. Levin, Fredric J. Seidler, and Theodore A. Slotkin. 2011. Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes. Neurotoxicology and Teratology. 33:329-332. doi:10.1016/ PMCID: PMC3071894
  • Seidler, Frederic J. and Theodore A. Slotkin. 2011. Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: Effects of organophosphates are distinct from those of glucocorticoids. Brain Research Bulletin. 85:225-230. doi:10.1016/j.brainresbull.2011.03.021 PMCID: PMC3109170.
  • Sledge, Damiyon, J. Yen, Terrell Morton, Laura Dishaw, Ann Petro, Sue Donerly, Elwood Linney, and Edward D. Levin. 2011. Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. Neurotoxicology and Teratology. 33:742-751. doi:10.1016/ PMCID: PMC3225562
  • Slotkin, Theodore A. 2011. Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity?. Reproductive Toxicology. 31:297-301. doi:10.1016/j.reprotox.2010.07.012 PMCID: PMC3025269.
  • Slotkin, Theodore A., Frederic J. Seidler, and Elliot R. Spindel. 2011. Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: Amelioration by Vitamin C. Neurotoxicology and Teratology. 33:431-434. doi:10.1016/ PMCID: PMC3109087.
  • Whitehead, Andrew, Fernando Galvez, Shu J. Zhang, Larissa M. Williams, and Marjorie F. Oleksiak. 2011. Functional Genomics of Physiological Plasticity and Local Adaptation in Killifish. Journal of Heredity. 102:499-511. doi:10.1093/jhered/esq077 PMCID: PMC3156563.
  • Yen, J., Sue Donerly, Edward D. Levin, and Elwood Linney. 2011. Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicology and Teratology. 33:735-741. doi:10.1016/ PMCID: PMC3225599.

Return to top

  • Adigun A, Ryde IT, Seidler FJ, Slotkin TA. Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells. Brain Research. 2010 May 6; 1329:36-44. PMCID: PMC2857560.
  • Adigun A, Wrench N, Slotkin TA. Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion. Environmental Health Perspectives. 2010 Feb; 118(2):210-215. PMCID: PMC2831919.
  • Alexeyenko A, Wassenberg DM, Lobenhofer EK, Yen J, Linney E, Sonnhammer E, Meyer JN. Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity. PLoS ONE. 2010 May 5; 5(5):e10465. PMCID: PMC2864754.
  • Boyd W, Crocker T, Rodriguez A, Leung M, Lehmann D, Freedman JH, Van Houten B, Meyer JN. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 2010 Jan 5; 683(1-2):57-67. PMCID: PMC2799044.
  • Clark BW, Matson CW, Jung D, Di Giulio RT. AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic killifish (Fundulus heteroclitus). Aquatic Toxicology. 2010 Aug 15; 99(2):232-240. PMCID: PMC2901414.
  • Cooper E, Stapleton H, Matson C, Di Giulio R, Shuler A. Ultraviolet treatment and biodegradation of dibenzothiophene: Identification and toxicity of products. Environmental Toxicology and Chemistry. 2010 Nov; 29(11):2409-2416. doi: 10.1002/etc.312. PMCID: PMC3085139
  • Kim B, Turski ML, Nose Y, Casad M, Rockman HA, Thiele D. Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs. Cell Metabolism. 2010 May 5; 11(5):353-63. doi:10.1016/j.cmet.2010.04.003.PMCID: PMC2901851.
  • Leung M, Goldstone JV, Boyd W, Freedman JH, Meyer JN. Caenorhabditis elegans Generates Biologically Relevant Levels of Genotoxic Metabolites from Aflatoxin B-1 but Not Benzo a pyrene In Vivo. Toxicological Sciences. 2010 Dec; 118:444-453. doi:10.1093/toxsci/kfq295.PMCID: PMC2984530.
  • Levin ED, Timofeeva OA, Yang L, Ryde IT, Wrench N, Seidler FJ, Slotkin TA. Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging. Behav. Brain Research. 2010 April 2; 208:319-327. doi:10.1016/j.bbr.2009.11.007. PMCID: PMC2831164.
  • Slotkin TA, Seidler FJ. Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an In vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PCI2 cells. Brain Research. 2010 Sep 24; 1353:36-52. doi:10.1016/j.brainres.2010.07.073. PMCID: PMC2933311.
  • Kumanyika SK, Parker L, Leslie S. Bridging the Evidence Gap in Obesity Prevention: A Framework to Inform Decision Making. Editors; Committee on an Evidence Framework for Obesity Prevention Decision Making; Institute of Medicine.

Return to top

  • Jung D, Cho Y, Collins LB, Swenberg JA, Di Giulio RT. Effects of benzo[a]pyrene on mitochondrial and nuclear DNA damage in Atlantic killifish (Fundulus heteroclitus) from a creosote-contaminated and reference site. Aquatic Toxicology. 2009 Oct 19; 95(1):44-51. doi:10.1016/j.aquatox.2009.08.003.PMCID: PMC2776085.
  • Levin ED, Aschner M, Heberlein U, Ruden D, Welsh-Bohmer KA, Bartlett S, Berger K, Chen L, Corl AB, Eddins D, French R, Hayden KM, Helmcke K, Hirsch HV, Linney E, Lnenicka G, Page GP, Possidente D, Possidente B, Kirshner A. Genetic aspects of behavioral neurotoxicology. NeuroToxicology. 2009 Sep; 30(5):741-53. doi:10.1016/j.neuro.2009.07.01.PMCID: PMC4086839.
  • Padilla S, Cowden J, Hinton DE, Yuen B, Law S, Kullman SW, Johnson R, Hardman RC, Flynn K, Au DW. Use of medaka in toxicity testing. Curr Protoc Toxicol. 2009 Feb;Chapter 1:Unit1.10. doi: 10.1002/0471140856.tx0110s39. PMCID: PMC4300524.
  • Slotkin TA, Seidler FJ. Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. Brain Research. 2009 Mar 31; 1263:23-32. doi:10.1016/j.brainres.2009.01.049. PMCID: PMC2670938.

Return to top

  • Lassiter TL, Ryde IT, MacKillop EA, Brown KK, Levin ED, Seidler FJ, Slotkin TA. Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood. Environmental Health Perspectives. 2008 Nov; 116:1456-1462. doi:10.1289/ehp.11673. PMCID: PMC2592263.
  • Matson CW, Clark BW, Jenny MJ, Fleming CR, Hahn ME, Di Giulio RT. Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental model. Aquatic Toxicology. 2008 May; 87(4):289-95. doi:10.1016/j.aquatox.2008.02.010. PMCID: PMC2413436.
  • Mattie MD, McElwee MK, Freedman JH. Mechanism of copper-activated transcription: activation of AP-1, and the JNK/SAPK and p38 signal transduction pathways. Journal of Molecular Biology. 2008 Nov; 383(5):1008-18. doi:10.1016/j.jmb.2008.08.080. PMCID: PMC2662727.
  • Roegge CS, Timofeeva OA, Seidler FJ, Slotkin TA, Levin ED. Developmental diazinon neurotoxicity in rats: later effects on emotional response. Brain Research Bulletin. 2008 Jan 31; 75:168-172.PMCID: PMC2253685.
  • Slotkin TA,Seidler FJ,Ryde IT, Yanai J. Developmental neurotoxicity of chlorpyrifos in an avian model: effects on acetylcholine and serotonin pathways. Neurotoxicology and Teratology. 2008 Sep-Oct:0(5):433-9. PMCID: PMC2659810.
  • Timofeeva OA, Sanders D, Seemann K, Yang L, Hermanson D, Regenbogen S, Kallepalli A, Rastogi A, Braddy D, Wells C, Perraut C, Seidler FJ,  Slotkin TA, Levin ED, Agoos S. Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion. Brain Research Bulletin. 2008 Dec 16; 77(6):404-11. doi:10.1016/j.brainresbull.2008.08.019. PMCID: PMC2612039.

Return to top

  • Buznikov, Gennady A., Lyudmila A. Nikitina, L.M. Rakic, I. Milosevic, V.V. Bezuglov, Jean M. Lauder, and Theodore A. Slotkin. 2007. The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine. Brain Research Bulletin. 74(4):221-231.
  • Hinton, David E., H. Segner, DWT Au, Seth W. Kullman, and R.C. Hardman. 2007. Liver toxicity. In: The Toxicology of Fishes . Taylor & Francis, Boca Raton, FL.
  • Jameson, Ruth R., Fredric J. Seidler, and Theodore A. Slotkin. 2007. Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon and diazinon. Environmental Health Perspectives. 115:65-70.
  • Lassiter, Chris S. and Elwood Linney. 2007. Embryonic expression and steroid regulation of brain Aromatase (cyp19a1b) in zebrafish (Danio rerio). Zebrafish. 4(1):49-58.
  • Ostrander, Gary K., Richard T. Di Giulio, David E. Hinton, M.R. Miller, and J.R. Rotchell. 2007. Chemical Carcinogensis. In: The Toxicology of Fishes . Taylor & Francis, Boca Raton, FL.
  • Shemer, Hilla and Karl G. Linden. 2007. Aqueous photodegradation and toxicity of the polycyclic aromatic hydrocarbons fluorene, dibenzofuran and dibenzothiophene. Water Research. 41(4):853-61.
  • Slotkin, Theodore A. and Fredric J. Seidler. 2007. Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Brain Research. 72:232-274.
  • Slotkin, Theodore A. and Fredric J. Seidler. 2007. Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats. Brain Research Bulletin. 73(4-6):301-9.
  • Slotkin, Theodore A. and Fredric J. Seidler. 2007. Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects. Reproductive Toxicology. 23(3):421-7.
  • Slotkin, Theodore A., E.A. MacKillop, I.T. Ryde, and Fredric J. Seidler. 2007. Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. Environmental Health Perspectives. 115:1306-1313.
  • Slotkin, Theodore A., E.A. MacKillop, I.T. Ryde, Charlotte A. Tate, and Fredric J. Seidler. 2007. Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine and divalent nickel. Environmental Health Perspectives. 115:93-101.
  • Slotkin, Theodore A., Fredric J. Seidler, and F. Fumagalli. 2007. Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environmental Health Perspectives. 115(6):909-16.
  • Timme-Laragy, Alicia R., C. Cockman, Cole W. Matson, and Richard T. Di Giulio. 2007. Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish. Aquatic Toxicology. 85(4):241-50.
  • Turski, M.L. and Dennis Thiele. 2007. Drosophila ctrl A functions as a copper transporter essential for development. Journal of Biological Chemistry. 282:24017-24026.

Return to top


  • Arzuaga, Xabier, Deena M. Wassenberg, Richard T. Di Giulio, and Adria A. Elskus. 2006. The chlorinated AHR ligand 3,32,4,42,5-pentachlorobiphenyl (PCB126) promotes reactive oxygen species (ROS) production during embryonic development in the killifish (Fundulus heteroclitus). Aquatic Toxicology. 76(1):13-23.
  • Billiard, Sonya M., Alicia R. Timme-Laragy, Deena M. Wassenberg, C. Cockman, and Richard T. Di Giulio. 2006. The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Toxicological Sciences. 92:526-536.
  • Cerutti, D.T. and Edward D. Levin. 2006. Cognitive impairments models using complementary species. In: Animal Models of Cognitive Impairment. (). CRC Press, NY. pp.315-342.
  • Cook, J., Nancy D. Denslow, T. Iguchi, Elwood Linney, A. Miracle, Joseph R. Shaw, Mark R. Viant, and Timothy R. Zacharewski. 2006. “Omics” approaches in the context of environment toxicology. (In: Emerging Molecular and Computational Approaches for Cross-Species Extrapolations). Chapter 1in: Society of Environmental Toxicology and Chemistry (SETAC) Annual Meeting 2006. Washington, DC. pp.1-29.
  • Embry, Michelle Rau, Sonya M. Billiard, and Richard T. Di Giulio. 2006. Lack of p53 induction in fish cells by model chemotherapeutics. Oncogene. 25(14):2004-2010.
  • Jameson, Ruth R., Fredric J. Seidler, Dan Qiao, and Theodore A. Slotkin. 2006. Adverse Neurodevelopmental Effects of Dexamethasone Modeled in PC12 Cells: Identifying the Critical Stages and Concentration Thresholds for the Targeting of Cell Acquisition, Differentiation and Viability. Neuropsychopharmacology. 31(8):1647-1658.
  • Jameson, Ruth R., Fredric J. Seidler, Dan Qiao, and Theodore A. Slotkin. 2006. Chlorpyrifos Affects Phenotypic Outcomes in a Model of Mammalian Neurodevelopment: Critical Stages Targeting Differentiation in PC12 Cells. Environmental Health Perspectives. 114:667-672.
  • Levin, Edward D. and Jerry J. Buccafusco. 2006. Animal Models of Cognitive Impairment. (). CRC Press, NY.
  • Levin, Edward D., Charles Perraut, Ninitia Pollard, and Jonathan H. Freedman. 2006. Metallothionein expression and neurocognitive function in mice. Physiology and Behavior. 87(3):513-518.
  • Shemer, Hilla and Karl G. Linden. 2006. Degradation and by-product formation of diazinon in water during UV and UV/H2O2 treatment. Journal of Hazardous Materials. 136:553-559.
  • Slotkin, Theodore A. and Fredric J. Seidler. 2006. Anomalous regulation of B-adrenoceptor signaling in brain regions of the newborn rat. Brain Research. 1077(1):54-58.
  • Slotkin, Theodore A., Edward D. Levin, and Fredric J. Seidler. 2006. Comparative Developmental Neurotoxicity of Organophosphate Insecticides: Effects on Brain Development are Separable from Systemic Toxicity. Environmental Health Perspectives. 114(5):746-751.
  • Slotkin, Theodore A., Charlotte A. Tate, I.T. Ryde, Edward D. Levin, and Fredric J. Seidler. 2006. Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environmental Health Perspectives. 114:1542-1545.
  • Timme-Laragy, Alicia R., Edward D. Levin, and Richard T. Di Giulio. 2006. Developmental and behavioral effects of embryonic exposure to the polybrominated diphenylether mixture DE-71 in the killifish (Fundulus heteroclitus). Chemosphere. 62(7):1097-1104.

Return to top

2000 – 2005: Superfund Chemicals’ Impact on Reproduction and Development


  • Aldridge, Justin E., Edward D. Levin, Fredric J. Seidler, and Theodore A. Slotkin. 2005. Developmental Exposure of Rats to Chlorpyrifos Leads to Behavioral Alterations in Adulthood, Involving Serotonergic Mechanisms and Resembling Animal Models of Depression. Environmental Health Perspectives. 113(5):527-531.
  • Aldridge, Justin E., Armando Meyer, Fredric J. Seidler, and Theodore A. Slotkin. 2005. Alterations in Central Nervous System Serotonergic and Dopaminergic Synaptic Activity in Adulthood after Prenatal or Neonatal Chlorpyrifos Exposure. Environmental Health Perspectives. 113(8):1027-1031.
  • Aldridge, Justin E., Armando Meyer, Fredric J. Seidler, and Theodore A. Slotkin. 2005. Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicology and Applied Pharmacology. 203(2):132-144.
  • Meyer, Armando, Fredric J. Seidler, Justin E. Aldridge, and Theodore A. Slotkin. 2005. Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos. Toxicology and Applied Pharmacology. 203(2):154-166.
  • Meyer, Joel N., David C. Volz, Jonathan H. Freedman, and Richard T. Di Giulio. 2005. Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary. Aquatic Toxicology. 73(4):327-341.
  • Nacci, Diane E., L. Coiro, Deena M. Wassenberg, and Richard T. Di Giulio. 2005. A non-destructive technique to measure cytochrome P4501A enzyme activity in living embryos of the estuarine fish Fundulus heteroclitus. Chapter Vol. 2 in: Techniques in Aquatic Toxicology. CRC Press, Inc., Boca Raton, FL. pp.209-226.
  • Qiao, Dan, Fredric J. Seidler, and Theodore A. Slotkin. 2005. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicology and Applied Pharmacology. 206(1):17-26.
  • Roy, Tara Sankar, Vikram Sharma, Fredric J. Seidler, and Theodore A. Slotkin. 2005. Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. Developmental Brain Research. 155(1):71-80.
  • Shemer, Hilla, Charles M. Sharpless, and Karl G. Linden. 2005. Photodegradation of 3,5,6-trichloro-2-pyridinol in aqueous solution. Water, Air & Soil Pollution. 168(1-4):145-155.
  • Slotkin, Theodore A. 2005. Developmental Neurotoxicity of Organophosphates: A Case Study of Chlorpyrifos. Chapter 21 in: Toxicity of Organophosphate and Carbamate Compounds. (Ramesh C. Gupta, ed). Elsevier Academic Press, San Diego, CA. pp.293-314.
  • Slotkin, Theodore A. and Fredric J. Seidler. 2005. The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. Developmental Brain Research. 158(1-2):115-119.
  • Slotkin, Theodore A., Kathleen K. Brown, and Fredric J. Seidler. 2005. Developmental Exposure of Rats to Chlorpyrifos Elicits Sex-Selective Hyperlipidemia and Hyperinsulinemia in Adulthood. Environmental Health Perspectives. 113(10):1291-1294. doi:10.1289/ehp.8133
  • Slotkin, Theodore A., Charlotte A. Tate, Mandy M. Cousins, and Fredric J. Seidler. 2005. Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. Developmental Brain Research. 160(2):219-230.
  • Song, Min Ok and Jonathan H. Freedman. 2005. Activation of Mitogen Activated Protein Kinases by PCB126 (3,3′,4,4′,5-Pentachlorobiphenyl) in HepG2 Cells. Toxicological Sciences. 84(2):308-318.
  • Timme-Laragy, Alicia R., Joel N. Meyer, Robert A. Waterland, and Richard T. Di Giulio. 2005. Analysis of CpG methylation in the killifish CYP1A promoter. Comparative Biochemistry and Physiology – Part C: Toxicology & Pharmacology. 141(4):406-411.
  • Wassenberg, Deena M., Abby L. Nerlinger, Lauren P. Battle, and Richard T. Di Giulio. 2005. Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities. Environmental Toxicology and Chemistry. 24(10):2526-2532.

Return to top


  • Aldridge, Justin E., Fredric J. Seidler, and Theodore A. Slotkin. 2004. Developmental Exposure to Chlorpyrifos Elicits Sex-Selective Alterations of Serotonergic Synaptic Function in Adulthood: Critical Periods and Regional Selectivity for Effects on the Serotonin Transporter, Receptor Subtypes, and Cell Signaling. Environmental Health Perspectives. 112(2):148-155.
  • Craft, Elena S., Michelle Rau Embry, Richard T. Di Giulio, and Jonathan H. Freedman. 2004. Evidence for the role of p53 in metal-induced activation of metallothionein gene expression. In: Metal Ions in Biology and Medicine: Proceedings of the Eighth International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext Publishers, Montrouge, France.
  • Dolinoy, Dana C. and Marie Lynn Miranda. 2004. GIS Modeling of Air Toxics Releases from TRI-Reporting and Non-TRI-Reporting Facilities: Impacts for Environmental Justice. Environmental Health Perspectives. 112(17):1717-1724.
  • Embry, Michelle Rau, Julia Whitaker, Jonathan H. Freedman, and Richard T. Di Giulio. 2004. Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants. Comparative Biochemistry and Physiology – Part C: Toxicology & Pharmacology. 137(4):335-342.
  • Icenogle, Laura M., N. Channelle Christopher, W. Paul Blackwelder, D. Patrick Caldwell, Dan Qiao, Fredric J. Seidler, Theodore A. Slotkin, and Edward D. Levin. 2004. Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicology and Teratology. 26(1):95-101.
  • Izrael, Michal, Eddy A. Van der Zee, Theodore A. Slotkin, and Joseph Yanai. 2004. Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. Journal of Neuroscience Research. 78(4):499-507.
  • Levin, Edward D., Holly A. Swain, Sue Donerly, and Elwood Linney. 2004. Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior. Neurotoxicology and Teratology. 26(6):719-723.
  • Linney, Elwood and Ava J. Udvadia. 2004. Construction and detection of fluorescent germline transgenic zebrafish. Chapter Vol. 254 in: Methods in Molecular Biology, 2004. Humana Press, Inc, Louisville, KY. pp.271-288.
  • Meyer, Armando, Fredric J. Seidler, Justin E. Aldridge, Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. 2004. Critical Periods for Chlorpyrifos-Induced Developmental Neurotoxicity: Alterations in Adenylyl Cyclase Signaling in Adult Rat Brain Regions after Gestational or Neonatal Exposure. Environmental Health Perspectives. 112(3):295-301.
  • Meyer, Armando, Fredric J. Seidler, and Theodore A. Slotkin. 2004. Developmental Effects of Chlorpyrifos Extend Beyond Neurotoxicity: Critical Periods for Immediate and Delayed-Onset Effects on Cardiac and Hepatic Cell Signaling. Environmental Health Perspectives. 112(2):170-178.
  • Qiao, Dan, Fredric J. Seidler, Yael Abreu-Villaca, Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. 2004. Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. Developmental Brain Research. 148(1):43-52.
  • Rhodes, M.C., Fredric J. Seidler, Dan Qiao, Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. 2004. Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. Toxicology and Applied Pharmacology. 195(2):203-217.
  • Roy, Tara Sankar, Fredric J. Seidler, and Theodore A. Slotkin. 2004. Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia. Developmental Brain Research. 148(2):197-206.
  • Slotkin, Theodore A. 2004. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicology and Applied Pharmacology. 198(2):132-151.
  • Slotkin, Theodore A. 2004. Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective. NeuroToxicology. 25(4):631-640.
  • Slotkin, Theodore A., Matthew C. Southard, Stacey J. Adam, Mandy M. Cousins, and Fredric J. Seidler. 2004. Alpha7 Nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos. Brain Research Bulletin. 64(3):227-235.
  • Wassenberg, Deena M. and Richard T. Di Giulio. 2004. Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in Fundulus heteroclitus. Environmental Health Perspectives. 112(17):1658-1664.
  • Wassenberg, Deena M. and Richard T. Di Giulio. 2004. Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors. Marine Environmental Research. 58(2-5):163-168.

Return to top


  • Aldridge, Justin E., Fredric J. Seidler, Armando Meyer, Indira Thillai, and Theodore A. Slotkin. 2003. Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. Environmental Health Perspectives. 111(14):1736-1743.
  • Buznikov, Gennady A., Theodore A. Slotkin, and Jean M. Lauder. 2003. Sea urchin embryos and larvae as biosensors for neurotoxins. In: Current Protocals in Toxicology. John Wiley & Sons, NY. pp.1.6.1-1.6.24.
  • Cooper, E.M. and Dharni Vasudevan. 2003. Comparison of hydroxynaphthoic acid isomer sorption onto goethite: Batch, ATR-FTIR and Computational chemistry approaches. In: Proceedings of the 226th ACS (American Chemical Society) National Meeting – Fall 2003. New York, NY.
  • Dam, K., Fredric J. Seidler, and Theodore A. Slotkin. 2003. Transcriptional biomarkers distinguish between vunerable periods for developmental neurotoxicity of chlorpyrifos: implications for toxicogenomics. Brain Research Bulletin. 59(4):261-265.
  • Garcia, S.J., Fredric J. Seidler, and Theodore A. Slotkin. 2003. Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities. Environmental Health Perspectives. 111(3):297-303.
  • Levin, Edward D., Elizabeth Chrysanthis, Kari Yacsin, and Elwood Linney. 2003. Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. Neurotoxicology and Teratology. 25(1):51-57.
  • Linney, Elwood and Ava J. Udvadia. 2003. Construction and detection of fluorescent germ-line transgenic zebrafish. In: Methods in Molecular Medicine. (). Humana Press,
  • Meyer, Armando, Fredric J. Seidler, Mandy M. Cousins, and Theodore A. Slotkin. 2003. Developmental Neurotoxicity Elicited by Gestational Exposure to Chlorpyrifos: When Is Adenylyl Cyclase a Target?. Environmental Health Perspectives. 111(16):1871-1876.
  • Meyer, Joel N. and Richard T. Di Giulio. 2003. Heritable adaptation and fitness costs in killifish (Fundulus heteroclitus) inhabiting a polluted estuary. Ecological Applications. 13(2):490-503.
  • Meyer, Joel N., Jim D. Smith, Gary W. Winston, and Richard T. Di Giulio. 2003. Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses. Aquatic Toxicology. 65(4):377-395. doi:10.1016/j.aquatox.2003.06.001
  • Meyer, Joel N., Deena M. Wassenberg, Sibel I. Karchner, Mark E. Hahn, and Richard T. Di Giulio. 2003. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environmental Toxicology and Chemistry. 22(10):2337-2343.
  • Nikitina, Lyudmila A., Gennady A. Buznikov, Jean M. Lauder, Fredric J. Seidler, and Theodore A. Slotkin. 2003. The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity. Environmental Health Perspectives. 111(14):536-544.
  • Qiao, Dan, Fredric J. Seidler, J.D. Violin, and Theodore A. Slotkin. 2003. Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. Developmental Brain Research. 147(1-2):183-190.
  • Seidler, Fredric J., Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. 2003. Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. Environmental Health Perspectives. 111(4):536-544.
  • Udvadia, Ava J. and Elwood Linney. 2003. Windows into development: historic, current, and future perspectives on transgenic zebrafish. Developmental Biology. 256(1):1-17.

Return to top


  • Adams, T.K., N. Saydam, F. Steiner, W. Schaffner, and Jonathan H. Freedman. 2002. Activation of gene expression by metal-responsive signal transduction pathways. Environmental Health Perspectives. 110(5):813-817.
  • Garcia, S.J., Fredric J. Seidler, and Theodore A. Slotkin. 2002. Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein. Developmental Brain Research. 133(2):151-161.
  • Kimura, Yoshishige, Ethan E. Corcoran, Koh Eto, Keiko Gengyo-Ando, Masa-aki Muramatsu, Ryoji Kobayashi, Jonathan H. Freedman, Shohei Mitani, Masatoshi Hagiwara, Anthony R. Means, and Hiroshi Tokumitsu. 2002. A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO Journal. 3:962-966.
  • Lassiter, Chris S., B. Kelley, and Elwood Linney. 2002. Genomic structure and embryonic expression of estrogen receptor beta a (ERBa) in zebrafish (Danio rerio). Gene. 292(1-2):141-151.
  • Levin, Edward D., Nii Addy, Avanti Baruah, Alana Elias, N. Channelle Christopher, Fredric J. Seidler, and Theodore A. Slotkin. 2002. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicology and Teratology. 24(6):733-741.
  • Liao, V.H-C and Jonathan H. Freedman. 2002. Differential display analysis of gene expression in invertebrates. Cellular and Molecular Life Sciences. 59:1256-1263.
  • Liao, V.H-C, J. Dong, and Jonathan H. Freedman. 2002. Molecular characterization of a novel, cadmium-inducible gene from Caenorhabditis elegans. Journal of Biological Chemistry. 277:42049-42059.
  • Mattie, Michael D. and Jonathan H. Freedman. 2002. Copper Inducible Gene Expression Regulated by Metals and Oxidative Stress Responsive Pathways. Trace Elements in Medicine (In Russian). 3:46.
  • Mattie, Michael D. and Jonathan H. Freedman. 2002. Copper Inducible Gene Expression Regulated by Metals and Oxidative Stress Responsive Pathways. In: Metal Ions in Biology and Medicine: Proceedings of the Seventh International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext Publishers, Reims, France. pp.108-112.
  • Meyer, Joel N. and Richard T. Di Giulio. 2002. Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA. Marine Environmental Research. 54(3-5):621-626.
  • Meyer, Joel N., Diane E. Nacci, and Richard T. Di Giulio. 2002. Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments. Toxicological Sciences. 68(1):69-81.
  • Miranda, Marie Lynn, Dana C. Dolinoy, and M. Alicia Overstreet. 2002. Mapping for Prevention: GIS Models for Directing Childhood Lead Poisoning Prevention Programs. Environmental Health Perspectives. 110(9):947-953.
  • Saydam, N., T.K. Adams, F. Steiner, W. Schaffner, and Jonathan H. Freedman. 2002. Regulation of Metallothionein Transcription by the metal responsive transcription factor MTF-1. Identification of signal transduction cascades that control metal-inducible transcription. Journal of Biological Chemistry. 277:20438-20445.
  • Schlenk, Daniel R. and Richard T. Di Giulio. 2002. Biochemical responses as indicators of aquatic ecosystem health. In: Biological Indicators of Aquatic Ecosystem Stress. American Fisheries Society, Bethesda, MD. pp.13-422.
  • Seidler, Fredric J., S. Padilla, and Theodore A. Slotkin. 2002. Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?. Environmental Health Perspectives. 110(11):1097-1103.
  • Slotkin, Theodore A., Charlotte A. Tate, Mandy M. Cousins, and Fredric J. Seidler. 2002. Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure. Developmental Brain Research. 133(2):163-173.
  • Wassenberg, Deena M., Erin E. Swails, and Richard T. Di Giulio. 2002. Effects of combined exposures to benzo[a]pyrene and 3,3′,4,4′,5-pentachlorobiphenyl on Fundulus heteroclitus. Marine Environmental Research. 54(3-5):279-283.

Return to top


  • Arthur, David and Edward D. Levin. 2001. Spatial and non-spatial visual discrimination learning in zebrafish (Danio rerio). Animal Cognition. 4:125-131.
  • Buznikov, Gennady A., V.V. Bezuglov, Lyudmila A. Nikitina, Theodore A. Slotkin, and Jean M. Lauder. 2001. Cholinergic regulation of sea urchin embryonic and larval development. Russian Journal of Physiology. 87(11):1548-1556.
  • Buznikov, Gennady A., Lyudmila A. Nikitina, V.V. Bezuglov, Jean M. Lauder, S. Padilla, and Theodore A. Slotkin. 2001. An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae. Environmental Health Perspectives. 109(7):651-661.
  • Garcia, S.J., Fredric J. Seidler, T.L. Crumpton, and Theodore A. Slotkin. 2001. Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. Brain Research. 891(1-2):54-68.
  • Levin, Edward D., Nii Addy, A. Nakajima, N. Channelle Christopher, Fredric J. Seidler, and Theodore A. Slotkin. 2001. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Developmental Brain Research. 130(1):83-89.
  • Navarro, H.A., P.V. Basta, Fredric J. Seidler, and Theodore A. Slotkin. 2001. Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect?. Developmental Brain Research. 130(2):249-252.
  • Raines, K.W., Fredric J. Seidler, and Theodore A. Slotkin. 2001. Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. Developmental Brain Research. 130(1):65-72.
  • Seidler, Fredric J. and Theodore A. Slotkin. 2001. Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells. Environmental Health Perspectives. 109(9):909-913.
  • Slotkin, Theodore A., Mandy M. Cousins, Charlotte A. Tate, and Fredric J. Seidler. 2001. Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Research. 902(2):229-243.
  • Sutton, D., Zbigniew Kabala, A.B. Francisco, and Dharni Vasudevan. 2001. Limitations and Potential of Commercially Available Rhodamine WT as a Groundwater Tracer. Water Resources Research. 37(6):1641-1656.
  • Toomey, Barbara H., Susan M. Bello, Mark E. Hahn, Susannah Cantrell, Peggy Wright, Donald E. Tillitt, and Richard T. Di Giulio. 2001. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquatic Toxicology. 53(2):127-138.
  • Vasudevan, Dharni, R.L. Fimmen, and A.B. Francisco. 2001. Tracer Grade Rhodamine WT: Structure of constituent isomers and their sorption behavior. Environmental Science & Technology. 35(20):4089-4096.
  • Willett, Kristine L., Laila Lienesch, William Reichert, and Richard T. Di Giulio. 2001. In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon (PAH) fluoranthene. Toxicology and Applied Pharmacology. 177(3):264-271.

Return to top


  • Auman, J.T., Fredric J. Seidler, and Theodore A. Slotkin. 2000. Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity. Developmental Brain Research. 121(1):19-27.
  • Cioci, L.K., Ling Qui, and Jonathan H. Freedman. 2000. Transgenic strains of the nematode caenorhabditis elegans as biomonitors metal contamination. Environmental Toxicology and Chemistry. 19(8):2122-2129.
  • Crumpton, T.L., Fredric J. Seidler, and Theodore A. Slotkin. 2000. Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation. Brain Research. 857(2):80-98.
  • Crumpton, T.L., Fredric J. Seidler, and Theodore A. Slotkin. 2000. Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?. Developmental Brain Research. 121(2):189-195.
  • Dam, K., Fredric J. Seidler, and Theodore A. Slotkin. 2000. Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. Developmental Brain Research. 121(2):179-187.
  • Tcherepanova, Irina, Lokesh Bhattacharyya, Charles S. Rubin, and Jonathan H. Freedman. 2000. Aspartic Proteases from the Nematode Caenorhabditis elegans. STRUCTURAL ORGANIZATION AND DEVELOPMENTAL AND CELL-SPECIFIC EXPRESSION OF asp-1. Journal of Biological Chemistry. 275(34):26359-26369.

Return to top