David Hinton



Location 1

Research Location
Coastal China northeast of Beijing, China

Research Objective
Metal pollutants, singly and as mixtures, are investigated in adults and offspring of exposed medaka (Oryzias latipes). Metals selected were detected by chemical analysis of hair of street sweepers in Huludao. A metal smelter releases metals to the air and they collect on street sweepers and in certain food items.

Collaborating Institution
Nicholas School of the Environment and Northeast Institute of Geography and Agricultural Ecology at the Chinese Academy of Sciences in Changchun, Jilin Province, Peoples Republic of China

Funding Source
K. C. Wong Education Foundation, Hong Kong and Northeast Institute of Geography and Agricultural Ecology at the Chinese Academy of Sciences in Changchun, Jilin Province, Peoples Republic of China

Students Involved
Associate Professor, Nalz (Angie) Zheng, has joined the Hinton laboratory for 1.5 years to learn aquatic toxicology and early life stage tests.

Location 2

Research Location
Hong Kong, China

Research Objective
Study 1:  To study imaging liver development/remodeling in the see-through medaka fish.  To complete a fish embryo toxicity test as an animal alternative method in hazard and risk assessment and scientific research.  To study the development of high-throughput embryo histoarray for quantitative molecular profiling in uniformly orientated medaka (Oryzias latipes) embryos.  To study the development of aquarium model fish as models for human disease.

Study 2:  Research will investigate the effects of endocrine disruptive compounds (EDCs) on reproduction and immune system in parents and offspring. Work will determine multigenerational and later life consequences of early life exposure.  We are identifying a doctoral student interested in doing a jointly supervised PhD with Dr. Doris Au in Hong Kong (City University) and Dr. David Hinton, Nicholas School.  Work will focus on development of medaka as a model for human aging (in the areas of telomere and bone metabolism).

Study 3:  Paul K. S. Lam, Chair Professor, and Director in concert with the executive committee of the State Key Laboratory in Marine Pollution has appointed Professor David E. Hinton as Academic Committee Member 20012-2016. Ciguatoxins in reef fishes are being investigated for their toxicity. Pharmaceuticals in sewage releases are monitored and laboratory studies designed to detect unwanted effects from such practices.

Study 4:  To uncover the transgenerational effects caused by hypoxia from F0 generation to F3 generation. The transgenerational effects to be investigated include reproductive impairments (e.g., hormonal disturbances, reproductive capacity, quality of gametes, fertilization) and developmental abnormalities.

Study 5:  To unravel the epigenetic alterations (i.e. DNA methylation pattern and histone modifications) associated with the observed trans-generational effects.

Study 6:  To identify possible epigenetic biomarkers indicative of hypoxic stress in parental and offsprings (F1-F3).

Study 7:  To compare the evolutionary similarities between aquatic organisms and mammals in terms of epigenetic mechanisms, and generalize the biomedical implications by hypoxic stress.

Collaborating Institution
City University of Hong Kong, University of Hong Kong (Projects 4-7 w/Professor Rudolf Wu)

Funding Source
Nicholas School of the Environment, City University of Hong Kong

Students Involved
Study 1:  N K M Cheung (post-grad), Alicia Burtner and Wyley Hodgson (MEM)

Study 2:  Roy Ye & Drew Peterson (Master of Philosophy students)

Study 3:  TBD: Individual projects are distributed among 4 Hong Kong universities and one university in mainland China




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