May 26, 2023: Comparative biology approaches to identify neurological targets of PFAS toxicity

Jason Cannon, PhD

Professor of Toxicology

Purdue University


Per- and polyfluoroalkyl substances (PFAS) are prominent public health concerns that have received much attention for adverse systemic health outcomes. Yet, impacts on the nervous system remain poorly understood. Published data on PFAS brain entry and modulation of neurotransmission suggest it is critical to identify how exposures may adversely affect the neurological function. Using a variety of in vitro and animal model systems, we have identified cell-type specific neuropathology and dysfunction possibly mediated by specific mitochondrial targets. Comparative analyses across a phylogenetic range of species suggest potential relevance to mental health disorders and neurodegenerative diseases.

About the Speaker: Dr. Cannon received a B.S. in physiology from Michigan State University, a Ph.D. in toxicology from the University of Michigan, and postdoctoral training in neurodegeneration at the Pittsburgh Institute for Neurodegenerative Diseases. He received a k99/r00 from NIEHS to launch his independent laboratory in 2012. Dr. Cannon has been extensively funded by NIEHS and other organizations such as DOD and the Michael J Fox Foundation. His research focuses on mechanisms of environmentally induced neurodegeneration using a comparative biology approach. Dr. Cannon is currently a Professor of Toxicology at Purdue University, where he also is Head of the Purdue University Interdisciplinary Life Science Ph.D. Program (PULSe) and Director of the Toxicology Graduate Program. He serves the toxicology community in variety of ways, as associate editor/editorial board member for prominent toxicology journals, presidential chain of the neurotoxicology specialty section for the society of toxicology, and a mentor for the Toxicology Mentoring and Skills Development Training (ToxMSDT).

Friday, May 26, 2023, 11:00 am – 12:15 pm Eastern

Grainger Hall Room 2102, Grainger Hall (9 Circuit Dr, Durham, NC)

Masks are optional for in-person attendees. Please stay home if you aren’t feeling well and join us via livestream instead (see below).

Click HERE to join the Zoom (no registration needed)! (Passcode: 2023)

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