Iain Drummond, PhD
Professor and Director
Kathryn W. Davis Center for Regenerative Biology and Aging
MDI Biological Laboratory
He / Him / His
Acute kidney injury is induced by ischemia as well as by many drugs and environmental toxins. Repeated injury can initiate a progression to non productive fibrotic repair states, leading eventually to kidney failure. To improve outcomes in chronic kidney disease, we are studying stem cell based kidney repair in the zebrafish and translating our findings to human stem cell-derived kidney tissue replacement. Understanding injury induced trophic factors for adult kidney stem cells in the fish informs us of key processes in stem cell mediated repair including stem cell activation from quiescence, chemotaxis to sites of new nephron development, nephron patterning, and cell invasiveness required to engraft functional new nephrons to an existing kidney.
About the Speaker: Dr. Drummond studies kidney organogenesis, genetic disease, and regeneration using the zebrafish as a model system. His lab uses in vivo imaging and targeted gene mutations to identify new human disease genes, reveal kidney morphogenetic processes, and to characterize kidney stem cell and growth factor interactions that drive kidney regeneration. Iain Drummond received his PhD from the University of California Berkeley in cell signaling and the heat shock response. His postdoctoral work with Rex Chisholm at Northwestern University Medical School and Vikas Sukhatme at University of Chicago lead to his interest in studying kidney organogenesis. From 1993 to 2018 he was a faculty member in the Department of Medicine at Harvard Medical School and most recently took the position of Scientific Director of the Davis Center for Regenerative Biology and Aging at Mount Desert Island Biological lab where he continues his NIH funded studies of kidney regeneration and stem cell derived tissue replacement.
Thursday, April 14, 12:00-1:15 pm Eastern
Field Auditorium Room 1112, Grainger Hall (9 Circuit Dr, Durham, NC)
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