Sep 30, 2022: Thinking inside the box: teasing out key interactions that drive PFAS distribution, accumulation, and effects through toxicokinetic modeling

Headshot of seminar speaker, Dr. Carla Ng, wearing tortoiseshell-rimmed glasses and a black top

Carla Ng, PhD

Associate Professor of Civil & Environmental Engineering

University of Pittsburgh

She / Her / Hers

Lab Website

Twitter: @Ng_lab

Accumulating knowledge on the fate, bioaccumulation, and effects of per- and polyfluoroalkyl substances (PFAS) points to specific molecular interactions associated with the adverse impacts on human and wildlife health. Numerous papers have investigated PFAS interactions with specific proteins and their partitioning to phospholipids. Despite these advances in our understanding at the molecular level, the bigger picture remains unclear. What strategies can we use to organize this information and extract the signal from the noise? In this talk I will discuss what we have (and haven’t) been able to explain by integrating molecular insights into mechanistic toxicokinetic models, and discuss continuing challenges in addressing this diverse class of ubiquitous environmental contaminants.

About the Speaker: Dr. Carla Ng is an Associate Professor in the Department of Civil and Environmental Engineering at the University of Pittsburgh, with secondary appointments in Environmental and Occupational Health and Chemical and Petroleum Engineering.  She received her PhD in Chemical & Biological Engineering from Northwestern University in 2008. Her research focuses on the development of models for the fate of chemicals in organisms and ecosystems, at the intersection of chemistry, biology and engineering. Active research areas include the development of mechanistic models for the bioaccumulation of PFAS in organisms, tracking the evolution of complex chemical mixtures in the environment, and exploring the role of the industrial food system on the fate of contaminants, with implications for human exposure.

Friday, September 30, 2022, 12:00-1:15 pm Eastern

NEW LOCATION: Love Auditorium, Levine Science Research Center B Room 101 (LSRC B 101) (308 Research Dr, Durham, NC)

Masks are REQUIRED regardless of vaccination status. Please stay home if you aren’t feeling well – you may attend via Zoom instead (see below).

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