At the one-dimensional (1D) level, chromatin is found as nucleosomes and at the three dimensional level (3D), chromatin is found in loops and topological domains, both of which regulate gene expression by allowing accessibility to the DNA wrapped up as chromatin. Inorganic arsenic (iAs) is a ubiquitous metal that impacts gene regulation through modulating the epigenome. We recently provided the epigenetic landscape (DNA methylation, histone PTMs and histone variants) mediated by iAs. We are now teasing how iAs by directly dysregulating the binding of CTCF (the ‘master weaver’ of the genome) results in oncogenic 3D rewiring of the genome.
About the Speaker: Dr. Yvonne Fondufe-Mittendorf is a Professor in the Department of Epigenetics at Van Andel Institute. Fondufe-Mittendorf investigates how environmental impacts, such as exposures to toxicants, disrupts natural epigenetics and influences health and disease. Her research — which blends epigenetics, toxicology, bioinformatics and medicine — aims to reveal insights that may be translated into new cancer prevention and treatment strategies. She earned her bachelor’s and master’s degrees from University of Ibadan, Nigeria, and her Ph.D. in molecular genetics from Georg-August Universitaet, Germany, followed by a postdoctoral fellowship at Northwestern University. Fondufe-Mittendorf has earned numerous awards and accolades for her research and mentorship, including the National Institutes of Health’s IDeA Thomas Maciag Award, University of Kentucky Research Professorship, and recognition from University of Kentucky’s Chellgreen Center.
Friday, November 18, 2022, 12:00-1:15 pm Eastern
Field Auditorium Room 1112, Grainger Hall (9 Circuit Dr, Durham, NC)
Masks are now optional for in-person attendees. Please stay home if you aren’t feeling well – you may attend via Zoom instead (see below).
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