Shobhan Gaddameedhi, PhD
Dept. of Biological Sciences & Toxicology Program
Center for Human Health and the Environment
North Carolina State University
He / Him / His
Do you sometimes wonder how your body knows when it is time to sleep or wake up? Every cell in our body is programmed with a biological (also called as ‘circadian’) clock that aligns our bodies with the day/night cycles of the earth. This clock controls numerous biological processes on a 24-hour cyclical rhythm of activity and rest. These processes range from fundamental biochemical and cellular events such as cell cycle, DNA repair, and inflammation to functional physiological events like sleep-wake cycles and metabolism. In this talk, Shobhan will highlight the recent findings of how the circadian clock regulates genomic stability through DNA repair and melanin pigmentation. In addition, he will highlight the mechanisms by which circadian clock disruption, through rotating night-shift work, influences genomic stability and carcinogenesis outcomes.
About the Speaker: Shobhan Gaddameedhi received his received his master’s degree from the University of Hyderabad, India and his PhD from North Dakota State University (2003-08). He pursued his post-doctoral training in the circadian biology and DNA repair fields with Prof. Aziz Sancar at UNC Chapel Hill (2008-14). Before joining NCSU as part of the Chancellor’s Faculty Excellence Program in Environmental Health Sciences in July 2020, he worked as an Assistant Professor at Washington State University (2014-20). Shobhan is a recipient of NIH/NIEHS K99/R00 Career Development Award (2013), DOD/CDMRP Career Development Award (2018), and NIH/NIEHS Outstanding New Environmental Scientist/ONES Award (2020). In addition, he is a recipient of UNC Postdoctoral Award for Research Excellence (2013), American Society for Photobiology New Investigator Award (2018), and Environmental Mutagenesis and Genomics Society (EMGS) Newly Independent Investigator Program Award (2018). Shobhan’s main scientific interests are determining the mechanisms by which the circadian clock regulates environmental health outcomes through ‘gene-environment’ interactions and identifying the mechanisms by which circadian disruption influences genomic instability, skin & cardiovascular toxicity, and environmental carcinogenesis outcomes. Shobhan hopes to translate these findings into therapeutic treatments for environmental health disorders in humans.
Friday, September 3, 12:00-1:15 pm Eastern
Field Auditorium Room 1112, Grainger Hall (9 Circuit Dr, Durham, NC)
Masks are REQUIRED. Per campus policy, all Duke faculty, staff, students, and visitors must wear masks while indoors, regardless of vaccination status.
Prefer to attend remotely? Register HERE to receive a Zoom link for our entire Fall 2021 seminar series!
You only need to register ONCE to receive the link for our entire Fall series.