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ITEHP Seminar: The Role of Melatonin in Pathophysiologic Responses to Air Pollution Exposure
November 20, 2020 @ 12:00 pm - 1:15 pm
LINCHEN HE, PhD CANDIDATE
Duke University Nicholas School of the Environment
The Role of Melatonin in Pathophysiologic Responses to Air Pollution Exposure
Melatonin is a hormone excreted by the pineal gland with a marked circadian rhythm. It is an important hormone that regulates many biological functions, including sleeping, reproduction, and immunity. Melatonin is also a potent antioxidant and anti-inflammatory molecular and may affect the lung function in asthmatic patients. However, the role of melatonin in pathophysiological responses to air pollution exposure is still unknown. Specifically, my research is to investigate the impacts of melatonin on the relationships of air pollution exposure with systemic oxidative stress and inflammation in healthy adults and pulmonary physiology in asthmatic children.