Category Archives: Symposium

Fall 2019 Seminar Series

Category : Symposium

Duke University Program in Environmental Health & Toxicology

Fall 2019 Seminar Series (Pharm 847-S/ENV 847-S)

Fridays 11:45 a.m. – 1:00 p.m.

Field Auditorium, Grainger Hall unless otherwise noted

 

Sept 6    Phillip West, Texas A&M University College of Medicine, Mitochondrial Control of Innate Immunity in Health and Disease

Sept 13  Rashmi Joglekar, PhD Candidate, Nicotine and Sexualization of the Brain

Sept 20  Alison Harrill, NIEHS, Assessing chemical risks unique to genetically sensitive subpopulations using Diversity Outbred mice

Sept 27  Sven-Eric Jordt, Duke University School of Medicine, The role of TRPA1 receptor in toxicology

Oct 4      Dan Richter, Duke University Nicholas School of the Environment, and Emmanuel Obeng-Gyasi, North Carolina A&T, Urban Lead Legacy: A Soil Scientist’s Perspective

Oct 11    Symposium: Bridging Across Levels of Analysis to Advance Neurotoxic Risk Determination: Toxicology for the Second Fifth of the 21st Century, 8:30 am – 3:00 pm, Symposium Chair: Dr. Edward D. Levin

Oct 18    Michael Falvo, US Dept. Veterans Affairs, Airborne Hazards in the Deployment Environment: Implications for US Military Veterans

Oct 25    Scott Kennedy, University of Washington, The Rise of Somatic Mutations During Aging and the Tools to Study Them

Nov 1     Michelle Block, Indiana University School of Medicine, Microglia and the Lung Brain Axis:  Implications for CNS Disease?

Nov 8     James Crall, Harvard University, Pesticides and pollinators: Identifying the behavioral impacts of chronic neonicotinoid exposure in bumblebees

Nov 15   Michael Slimak, US EPA, EPA’s Sustainable and Healthy Communities (SHC) Research Program

Nov 22   Christine Payne, Duke University Dept. of Mechanical Engineering & Materials Science, Nanoparticle-cell interactions: Importance for human health

Nov 29   Thanksgiving Break

Dec 6     Rafael Trevisan, Duke University post-doctoral researcher, Using zebrafish as a model to investigate the potential threat of nanoplastics to aquatic species

Dec 13   Justin Conley, US EPA, Fetal and neonatal effects of in utero exposure to perfluoroalkyl ether acids


Spring Symposium Recap

Category : News , Symposium

On March 7th, ITEHP co-hosted the Spring 2014 Symposium, Cognitive Impairment Caused by Developmental Neurotoxic Exposure: Mechanisms, Consequences and Therapeutic Treatment, at the Searle Center. All images are courtesy of Steve McCaw, NIEHS.

 

SusanMurphy

Dr. Susan K. Murphy, Director of Duke NICHES Children’s Environmental Health and Disease Prevention Research Center

 

 

 

Susan Murphy, Ph.D., welcomes guests to the Spring 2014 Symposium, which was hosted by Duke’s Integrated Toxicology and Environmental Health Program, the Duke Superfund Research Center, and the Duke NICHES Children’s Environmental Health and Disease Prevention Research Center.

 

 

 

Edward Levin, Ph.D.

Edward Levin, Ph.D.

 

 

 

Dr. Edward Levin introduces the symposium theme, Cognitive Impairment Caused by Developmental Neurotoxic Exposure: Mechanisms, Consequences and Therapeutic Treatment. Dr. Levin is the director of the Neural and Behavioral Toxicity Assessment Core in the Duke Superfund Research Center.

 

 

 

 

 

 

 

Phillip Landrigan, M.D., M.Sc., Mount Sinai School of Medicine

Phillip Landrigan, M.D., M.Sc., Mount Sinai School of Medicine

 

 

 

 

Dr. Phil Landrigan visits Duke to present his talk titled, The Vunerable Developing Human Brain is Impacted by Toxic Environmental ExposuresLandrigan encouraged attendees to get involved in community outreach activities and to practice research translation to non-scientific audiences.

 

 

 

 

 

 

 

Frederica Perera, Dr.P.H., Ph.D., Columbia University

Frederica Perera, Dr.P.H., Ph.D., Columbia University

 

 

 

Dr. Frederica Perera from Columbia University explains her work in a talk titled, Molecular Epidemiology and the Impacts of Prenatal and Early Childhood Exposure to Environmental Neurotoxicants in a New York City Cohort. Studies show the odds of impacts on brain development in kids with high exposures to PAHs are almost three-times greater than kids without exposure. To learn more about children’s environmental health, visit the Columbia Center for Children’s Environmental Health website.

 

 

 

 

 

Kim Dietrich, Ph.D., M.A., University of Cincinnati

Kim Dietrich, Ph.D., M.A., University of Cincinnati

 

 

 

Dr. Kim Dietrich talks about childhood exposure to lead in his presentation: The Societal and Economic Costs of Cognitive and Behavioral Impairments due to Developmental Neurotoxicity Across the Lifespan: the Case of Lead.  Dietrich’s research shows that beyond IQ levels, there is a relationship between lead exposure and criminal behavior in adolescents and adults.

 

 

 

 

 

 

 

 

Scott Kollins, Ph.D., Duke University

Scott Kollins, Ph.D., Duke University

 

 

Dr. Scott Kollins of Duke University presents Unpacking the ADHD Phenotype: Relevance for Understanding the Effects of Environmental Exposures. He explains there is an increase in the prevalence of ADHD and environmental exposures. A recent study conducted by Duke’s NICHES program finds an association between ADHD and secondhand smoke. For more information, follow this link.

 

 

 

 

 

 

 

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Dr. Ed Levin returns to the podium to present his research in Long-term Cognitive Impacts from Early Life Exposure to Pesticides and Nicotine in Rats and Zebrafish. His research shows there are normal sex differences in brain function that are obliterated or reversed from environmental exposures. Click here to see Dr. Levin and Dr. Slotkin’s most recent publication on the effects of prenatal co-exposure to dexamethasone and chlorpyrifos. For a summary of this article and another by T.Slotkin, check out Duke Superfund’s ToxInsider blog.

 

 

 

 

 

 

 

Theodore Slotkin, Ph.D., Duke University

Theodore Slotkin, Ph.D., Duke University

 

 

 

 

Dr. Theodore Slotkin presents a talk titled, Nicotine, Tobacco, and Brain Development, from Fetus to Adolescent: Finding the Smoking Gun. His research shows that the drug taken continuously impacts the brain far more than the episodic drug. 

 

 

 

 

 

 

 

Charles Vorhees, Ph.D., Cincinnato Children's Hospital

Charles Vorhees, Ph.D., Cincinnato Children’s Hospital

 

 

 

 

Dr. Charles Vorhees presents Cognitive and Behavioral Effects of Developmental Exposure to Manganese and Stress in Rats. He presented data showing how early life exposure to manganese effects rats’ sociability, depression, and anxiety.

 

 

 

 

 

 

 

 Thank you for attending our Spring 2014 Symposium! 

 

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Genetics and Environmental Mutagenesis Society Spring Meeting

Category : News , Symposium

Genetics and Environmental Mutagenesis Society

GEMS Spring Meeting – April 28, 2014

U.S. EPA, RTP Campus Auditorium

 

THE CARCINOGENICITY OF OUTDOOR AIR POLLUTION

               In October 2013, the International Agency for Research on Cancer (IARC), a specialized agency of the World Health Organization (WHO), evaluated outdoor air pollution and particulate matter as a Group 1 (known) human lung carcinogen.  This symposium will present some of the key data used to support this evaluation as well as some of its implications.

 

Registration Cost:  Free

Registration Procedure:  Register by e-mailing Dr. William Ward at ward.william@epa.gov.  Please provide (a) your name and (b) whether you plan to attend in person or via webinar.  Please register by April 18 to insure adequate webinar capacity.  Webinar information will be provided prior to the meeting on the GEMS website at http:/www.gems-nc.org.

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Requirement for Entry to EPA:  For detailed directions to the EPA campus link to:  http://www.epa.gov/rtp/campus/location/location.htm.  For those attending in person, please enter the U.S. EPA facility on T.W. Alexander Drive in RTP through the front lobby of Building C and provide a photo I.D. to the guard at the desk.  If you want to bring a laptop, you must complete a form provided by the guard at the time of entry.

PROGRAM

 

  8:50 –   9:00            Welcome:    Channa Keshava (EPA, RTP, GEMS President-Elect) and Bill Kaufman (UNC, GEMS President)

9:00 –   9:10            Overview

David DeMarini (EPA/RTP)

9:10 – 10:10            Lung Cancer Epidemiology of Outdoor Air Pollution

Aaron Cohen (Health Effects Institute, Boston)

10:15 – 10:30            Coffee Break

10:30 – 11:30            Mutagenicity of Outdoor Air Pollution Worldwide

Paul A. White (Health Canada, Ottawa)

11:30 –   1:00            Lunch (on your own/EPA cafeteria)

1:00 –   1:30            Carcinogenicity of Polluted Air in Experimental Animals

George M. Woodall Jr. (EPA, RTP)

1:30 –   2:00            Genotoxicity & Epigenetics of Polluted Air in Humans

David M. DeMarini (EPA, RTP)

2:00 –   2:45            How Air Pollution is Regulated by the U.S. EPA

Bryan J. Hubbell (EPA, RTP)

2:45 –   3:00            Discussion

  

 Bio-sketches of Speakers

Dr. Aaron J. Cohen

Dr. Cohen is Principal Scientist at the Health Effects Institute (HEI) in Boston, MA, where he has worked since 1990. At HEI Dr. Cohen manages an international program of epidemiologic research on the health effects of air pollution, and is involved in developing and managing HEI’s US and international research programs. In these capacities he led HEI’s review of the literature on the health effects of air pollution in the developing countries of Asia, and is co-coordinator of HEI’s Health Outcomes Research program, which assesses the health impacts of actions taken to improve air quality. Past HEI responsibilities have included: the organization and management of epidemiologic research projects such as the Reanalysis of the American Cancer Society and Six-City studies of air pollution and mortality, and multi- city time-series studies of air pollution and daily mortality in Europe, North America Asia and Latin America. Dr. Cohen has served since 1999 as a Temporary Advisor to the World Health Organization (WHO) on the evaluation of epidemiologic evidence, air pollution health impact assessment, and air quality guideline development. He co-chaired the Expert Group that produced estimates of the global burden of disease due to Ambient Air Pollution for the Global Burden of Disease 2010 project and is a member of the Core Analytic Team or Global Burden of Disease 2013. http://www.healthmetricsandevaluation.org/gbd/2013

Dr. Cohen holds a D.Sc. in Epidemiology (1991), and Masters in Public Health (1985) from the Boston University School of Public Health, where he is Adjunct Assistant Professor of Environmental Health. He is also a Registered Respiratory Therapist (RRT), and worked for 15 years in newborn intensive care, and subsequently as Research Associate in Perinatal Epidemiology, at Brigham and Women’s Hospital in Boston.

 

Aaron J Cohen, MPH DSc

Principal Scientist

Health Effects Institute

101 Federal Street Suite 500

Boston, MA 02110-1817

TEL 617-488-2325

acohen@healtheffects.org

http://www.healtheffects.org

 

Dr. Paul A. White

Dr. White is currently a Canadian government research scientist, and adjunct professor of biology at the University of Ottawa.  With respect to the former he is the Leader of the Genetic Toxicology Lab Group. With respect to the latter, he is a member of the Centre for Advanced Research in Environmental Genomics, the Ottawa-Carleton Institute of Biology, and the graduate program in Chemical and Environmental Toxicology.  He received his B.S. and Ph.D. from McGill University in Montreal, Canada.  He currently (2014) has 24 years of multidisciplinary research experience investigating the sources, fate and hazards of mutagenic and carcinogenic contaminants; in particular those presented as complex mixtures in complex environmental matrices (e.g., urban air, vehicle, contaminated soils).  He has coordinated and guest edited the most up-to-date compilations on the sources, fate and hazards of environmental mutagens in complex matrices (e.g., air, water, soil, sediment).  The series of 13 review articles, which includes three from his group, was published in Mutation Research Reviews in 2004 and 2007.  As such, Dr. White is one of the leading experts on environmental mutagens, and in particular, mutagens in complex environmental matrices. His current work is investigating the sources, fate and hazards of mutagens and carcinogens in contaminated soils, vehicular exhausts, settled house dust, contaminated urban air, tobacco smoke, and cannabis smoke.  In addition, his current work is investigating the suitability of various in vitro and in vivo approaches for genetic toxicity assessment, regulatory decision-making, and risk assessment, and employing genomic and proteomic methods to identify biomarkers of exposure to, or effect from, environmental mutagens in complex matrices. He has established numerous national and international collaborations involving the University of Toronto, Texas A&M University, the University of Saskatchewan, the University of Ottawa, Carleton University, Umeå University (Sweden), the Danish National Research Centre for the Working Environment, King’s College, London, Swansea University, Litron Laboratories, BioReliance Corp, Integrated Laboratory Systems, the USFDA, the USEPA, Dow, Sanofi-Aventis, the International Life Sciences Institute (ILSI), and the RIVM (Holland). He has been invited to participate in numerous national and international activities coordinated by ECVAM, ECETOC, COLIPA, ILSI, and IARC. He served as Editor-in-Chief of Environmental and Molecular Mutagenesis (EMM) from 2007 to 2011, and is currently a member of the editorial boards of EMM and Mutation Research Reviews.

 

Paul A. White, Ph.D.

Environmental Health Sciences & Research Bureau

Health Canada

Tunney’s Pasture 0803a

Ottawa, Ontario K1A 0L2

Canada

TEL 613-941-7373

paul.white@hc-sc.gc.ca

 

Dr. George M. Woodall, Jr.

Dr. Woodall received his Ph.D. in Toxicology from North Carolina State University in 1996, and previously attained a Master’s of Science in Environmental Health from East Tennessee State University (1985) and a Bachelor of Science in Microbiology and Cell Science (1983) from the University of Florida. Dr. Woodall currently serves as a Toxicologist at the National Center for Environmental Assessment (NCEA) of the US EPA, where he works under the Human Health Risk Assessment Program in performing chemical risk assessments, and in developing and improving risk assessment methods. He is actively reviewing and analyzing the potential neurotoxic and cancer effects from styrene exposure; provides scientific support to the Office of Air Quality Planning and Standards of the US EPA for the Risk and Technology Review program; and actively co-leads an interagency Information Management Working Group which strives to provide a basis for collaborative approaches and sharing of the key information relevant to developing human health risk assessments. Dr. Woodall has served on the National Advisory Committee for Acute Exposure Guideline Levels (AEGLs), and has served on or chaired several expert panels for the OECD. He received the 2008 Science and Technology Achievement Award for the paper: A review of the mutagenicity and rodent carcinogenicity of ambient air, which was co-authored with Larry Claxton. He previously held the position of Senior Toxicologist with the American Petroleum Institute (API); while in that position, he led the organization for and chaired a symposium on health research and risk assessment for hydrogen sulfide. He is author or co-author of over 20 peer-reviewed articles and book chapters, and numerous governmental and intergovernmental reports. Dr. Woodall is also active as an officer in the Risk Assessment Specialty Section of the Society of Toxicology, is a current Councilor for the Genetic and Environmental Mutagenesis Society (GEMS), and a past-chair of the Dose Response Specialty Group of the Society for Risk Analysis.

 

Dr. George M. Woodall, Jr.

National Center for Environmental Assessment

U.S. Environmental Protection Agency

Research Triangle Park, NC 27711

TEL 919-541-3896

woodall.george@epa.gov

 

Dr. David M. DeMarini

Dr. DeMarini received the B.S. (1972), M.S. (1974), and Ph.D. (1980) in Biological Sciences (genetics) at Illinois State University, Normal, IL, studying under Dr. Herman E. Brockman.  From 1980-1982, he did postdoctoral research at the Biology Division, Oak Ridge National Laboratory, Oak Ridge, TN.  He then was a Research Geneticist at the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC from 1983-1984.  He began his current position as a Genetic Toxicologist at the US Environmental Protection Agency (US EPA), Research Triangle Park, NC in 1985.  He is also an Adjunct Professor, Dept. of Environ. Sci. & Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC (1991-present).  He is a member of the Environmental Mutagenesis and Genomics Society (EMGS) and the Genetics and Environmental Mutagenesis Society (GEMS).  He has served as President of EMGS, GEMS, and of the International Association of Environmental Mutagenesis and Genomics Societies (IAEMGS).  He is an Editor of Mutation Research–Reviews (1998-present) and is on the Editorial Board of Environmental and Molecular Mutagenesis (1984-1989, 1993-present) and Genes and Environment (2006-present).  He has organized conferences, symposia, and training courses internationally, and has given invited lectures at more than 130 conferences in 55 countries.  He has served on both the1986 and 2004 Tobacco Smoking and Cancer Monographs of the International Association for Research on Cancer (IARC) with WHO in Lyon, France, as well as the IARC Monographs on Drinking Water/Arsenic, Indoor Air, Human Carcinogens, Auto and Diesel Exhaust, and Outdoor Air.  He Chaired the IARC Monograph on Drinking Water, Food, and Industrial Chemicals (2011).  He has published >170 articles and received the Alexander Hollaender Award from the EMGS in 2011.  He has mentored 20 graduate students and postdocs through is adjunct professorship at UNC-Chapel Hill.  His research interests are molecular mechanisms of mutagenesis, mutation spectra, complex mixtures, and biomarkers of mutation in humans.

Dr. David M. DeMarini

Integrated Systems Toxicology Division (B105-03)

U.S. Environmental Protection Agency

Research Triangle Park, NC 27711

TEL 919-541-1510

demarini.david@epa.gov

 

Dr. Bryan J. Hubbell

Dr.  Hubbell leads the Risk and Benefits Group in the Health and Environmental Impacts Division of the Office of Air and Radiation in the U.S. Environmental Protection Agency. He has written and presented extensively in the U.S. and internationally on the health and environmental impacts of air pollution and economic benefits and costs of air quality regulations, serving as the principal benefits analyst for many of EPA’s regulatory analyses over the last decade, and led the project team that developed the environmental Benefits Mapping and Analysis Program (BenMAP).  He obtained his B.S. in political science from Appalachian State University in Boone, NC, and his Ph.D. in economics from North Carolina State University in Raleigh.  His research interests include health and environmental impact assessments methods and improving methods for the valuation of health and environmental changes.

 

Dr. Bryan J. Hubbell

Health and Environmental Impacts Division

Office of Air and Radiation

U.S. Environmental Protection Agency

Research Triangle Park, NC 27711

TEL 919-541-0621

hubbell.bryan@epa.gov


ITEHP Spring Symposium, March 7

Category : News , Symposium

The 2014 Duke Toxicology Spring Symposium “Cognitive Impairment Caused by Developmental Neurotoxic Exposure: Mechanisms, Consequences and Therapeutic Treatment” will be held March 7, 2014, 9AM-3PM in the Searle Conference Center, Duke University. This symposium is sponsored by the Duke University Integrated Toxicology and Environmental Health Program, Duke Superfund Research Center and the Duke NICHES Children’s Environmental Health and Disease Prevention Research Center.

Synopsis: Neurotoxic exposure during pregnancy and early childhood can cause long-lasting cognitive dysfunction. Learning impairment and attention deficit have been found after early life exposure to heavy metals and pesticides. Developmental exposures to other environmental chemicals and drugs are also being found to cause persisting neurotoxicity which leads to long-term cognitive dysfunction.  This symposium brings clinicians and researchers together to advance understanding of the risks posed by developmental neurotoxicity to the cognitive function of children who will ultimately determine future prospects of our society. — For more information, including the agenda and driving directions, please visit this page.

Registration is required for this event.

 


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