Monthly Archives: December 2014

Jordan Kozal wins Best Poster at SETAC 2014!

Category : Uncategorized

Congratulations to Jordan Kozal, 2nd year ITEHP student, for her Best Student Poster award at the 2014 SETAC North America meeting in Vancouver, CA. Jordan’s poster focused on her research of PAH cardiotoxicity in Elizabeth River, VA killifish.

JordanKozal


Symposium Recap!

Category : Uncategorized

Endocrine researchers explore dimensions of dose response

By Eddy Ball, NIEHS

The Duke University Integrated Toxicology and Environmental Health Program held its annual fall symposium Oct. 24 in the Searle Center Lecture Hall.

Speakers at the symposium shared their latest findings involving a new paradigm of nonmonotonic dose response (NMDR) involved in low-dose exposures to hormones and endocrine-disrupting chemicals. The paradigm, which remains controversial, is counterintuitive for classical toxicologists, who point to the contention by Paracelsus, “The dose makes the poison,” as a guiding principle.

Supporters of the nonmonotonic paradigm argue that exposure to endocrine-disrupting chemicals at low doses can have significant effects that are not seen at higher dose levels. Advocates point to mechanisms unique to the endocrine system, such as receptor saturation and feedback inhibition, that blunt the effects of higher doses.

“Interpretation of these new [low-dose] results is challenging, particularly within regulatory landscapes and risk assessment frameworks that operate under the assumption of a linear relationship between exposure dose and adverse effect,” said symposium chair Heather Stapleton, Ph.D., of Duke University, as she opened the meeting.

Stapleton introduced a program of researchers supported by NIEHS and the U.S. Environmental Protection Agency (EPA), who discussed their findings against a backdrop of two important documents — a draft state-of-the-science paper  written by EPA in June 2013 and the external peer review  of that paper published by the National Research Council (NRC) earlier this year…..

 

Please read the full article here.

 


Tox Seminar with Mark Robson, PhD, MPH 12/5

Category : News , toxseminar

picture-49This Friday’s Tox Seminar features Dr. Mark Robson with Rutgers University. His talk is titled “Challenges and Opportunities in Agricultural Environmental Health.” Join us in Field Auditorium at noon.


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