Recent Publications

2018

  • Massarsky A, Abdel A, Glazer L, Levin ED, Di Giulio RT. Neurobehavioral effects of 1,2propanediol in zebrafish (Danio rerio). Neurotoxicology. 65:111-124.
  • Massarsky A, Prasad GL, Di Giulio RT. Total particulate matter from cigarette smoke disrupts vascular development in zebrafish brain (Danio rerio). Toxicology and Applied Pharmacology. 339:85-96.
  • Pitt JA, Kozal JS, Jayasundara N, Massarsky A, Trevisan R, Geitner N, Wiesner M, Levin ED, Di Giulio RT. Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio). Aquatic Toxicology. 194:185-194.

2017

  • Massarsky A, Kozal JS, Di Giulio RT. Glutathione and zebrafish: Old assays to address a current issue. Chemosphere. 168: 707-715.
  • Yang Y, Chen B, Hower J, Schindler M, Winkler C, Brandt J, Di Giulio R, Ge J, Liu M, Fu Y, Zhang L, Chen Y, Priya S, Hochella MF Jr. Discovery and ramifications of incidental Magnéli phase generation and release from industrial coal-burning. Nature Communications. 2017 8:194.
  • Hartman JH, Kozal JS, Di Giulio RT, Meyer JN. Zebrafish have an ethanol-inducible hepatic 4nitrophenol hydroxylase that is not CYP2E1-like. Environmental Toxicology and Pharmacology. 54:142-145.
  • Mu J, Chernick M, Dong W, Di Giulio RT, Hinton DE. Early life co-exposures to a real-world PAH mixture and hypoxia result in later life and next generation consequences in medaka (Oryzias latipes). Aquatic Toxicology. 190:162-173.
  • Jayasundara N, Fernando PW, Osterberg JS, Cammen KM, Schultz TF, Di Giulio RT. Cost of Tolerance: Physiological Consequences of Evolved Resistance to Inhabit a Polluted Environment in Teleost Fish Fundulus heteroclitus. Environmental Science and Technology. 51:8763-8772.
  • Brown DR, Thompson J, Chernick M, Hinton DE, Di Giulio RT. Later life swimming performance and persistent heart damage following subteratogenic PAH mixture exposure in the Atlantic killifish (Fundulus heteroclitus). Environmental Toxicology and Chemistry. 2017 36:3246-3253.
  • Massarsky A, Abdel A, Glazer L, Levin ED, Di Giulio RT. Exposure to 1,2-Propanediol Impacts Early Development of Zebrafish (Danio rerio) and Induces Hyperactivity. Zebrafish. 14:216-222.
  • Lindberg CD, Jayasundara N, Kozal JS, Leuthner TC, Di Giulio RT. Resistance to polycyclic aromatic hydrocarbon toxicity and associated bioenergetic consequences in a population of Fundulus heteroclitus. Ecotoxicology. 26:435-448.
  • Brandt JE, Bernhardt ES, Dwyer GS, Di Giulio RT. Selenium Ecotoxicology in Freshwater Lakes Receiving Coal Combustion Residual Effluents: A North Carolina Example. Environmental Science and Technology. 51:2418-2426.
  • Raftery TD, Jayasundara N, Di Giulio RT. A bioenergetics assay for studying the effects of environmental stressors on mitochondrial function in vivo in zebrafish larvae. Comparative Biochemistry and Physiology C: Toxicology an Pharmacology. 192:23-32.

 

2016

  • Massarsky A, Bone AJ, Dong W, Hinton DE, Prasad GL, Di Giulio RT. AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos. Toxicology and Applied Pharmacology. 309:63-76.
  • Brown DR, Clark BW, Garner LV, Di Giulio RT. Embryonic cardiotoxicity of weak aryl hydrocarbon receptor agonists and CYP1A inhibitor fluoranthene in the Atlantic killifish (Fundulus heteroclitus). Comparative Biochemistry and Physiology C: Toxicology and Pharmacology. 188:45-51.
  • Matson CW, Bone AJ, Auffan M, Lindberg TT, Arnold MC, Hsu-Kim H, Wiesner MR, Di Giulio RT. Silver toxicity across salinity gradients: the role of dissolved silver chloride species (AgCl x ) in Atlantic killifish (Fundulus heteroclitus) and medaka (Oryzias latipes) early lifestage toxicity. Ecotoxicology. 25: 1105-18.
  • Riley AK, Chernick M, Brown DR, Hinton DE, Di Giulio RT. Hepatic Responses of Juvenile Fundulus heteroclitus from Pollution-adapted and Nonadapted Populations Exposed to Elizabeth River Sediment Extract. Toxicologic Pathology. 44:738-48.

2015

  • RT Di Giulio, BW Clark. 2015. The Elizabeth River story: a case study in evolutionary toxicology. Journal of Toxicology and Environmental Health, Part B – Critical Reviews. 18(6): 259-298.
  • N Jayasundara, JS Kozal, MC Arnold, SSL Chan, RT Di Giulio. 2015. High-Throughput Tissue Bioenergetics Analysis Reveals Identical Metabolic Allometric Scaling for Teleost Hearts and Whole Organisms. PLOS ONE. 10(9). doi: 10.1371/journal.pone.0137710
  • A Massarsky, N Jayasundara, JM Bailey, AN Oliveri, ED Levin, GL Prassad, RT Di Giulio. 2015. Teratogenic, Bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine.  Neurotoxicology and Teratology. 51: 7-88. doi: 10.1016/j.ntt.2015.09.006
  • MC Arnold, L Friedrich, T Lindberg, M Ross, N Halden, E Bernhardt, V Palace, and RT Di Giulio. Microchemical analysis of selenium in otoliths of two West Virginia fishes captured near mountaintop coal removal mining operations. Environmental Toxicology and Chemistry. 34 (5): 1039-1044. doi 10.1002/etc.2885
  • DE Gorka, JS Osterberg, CA Gwin, BP Colman, JN Meyer, ES Bernhardt, CK Gunsch, RT Di Giulio, J Lui. 2015. Reducing Environmental Toxicity of Silver Nanoparticles through Shape Control. Environmental Science & Toxicology. 49(16): 10093-10098. doi: 10.1021/acs.est.5b01711
  • N Jayasundara, L Van Tiem, JN Meyer, K Erwin, RT Di Giulio. 2015.  AHR2 mediated transcriptomic responses underlying the syngergistic cardiac developmental toxicity of PAHs. Toxicological Sciences. 143(2): 469-481. doi: 10.1093/toxsci/kfu245
  • DR Brown, BW Clark, LVT Garner, RT DI Giulio. 2015. Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists. Environmental Science and Pollution Research. 22(11): 8329-8338. doi: 10.1007/s11356-014-3969-2
  • AJ Bone, CW Matson, BP Coleman, X Yang, J Meyer, RT Di Giulio. 2015. Silver nanoparticle toxicity to  Atlantic killifish (Fundulus heteroclitus) and Caenorhabditis elegans: A comparison of laboratory, mesocosm and microcosm studies. Environmental Toxicology and Chemistry. doi: 10.1002/etc.5620211222.

2014

  • BW Clark, AJ Bone, RT Di Giulio. 2014. Resistance to teratogenesis by F1 and F2 embryos of PAH-adapted Fundulus heteroclitus is strongly inherited despite reduced recalcitrance of the AHR pathway. Environmental Science and Pollution Research. 21(24): 13898-13908. doi: 10.1007/s11356-013-2446-7
  • M Fang, GJ Getzinger, EM Cooper, BW Clark, LVT Garner, RT Di Giulio, PL Ferguson, and HM Stapleton. 2014.  Effect-directed analysis (EDA) of Elizabeth River pore water: developmental toxicity in zebrafish (Danio rerio). Environmental Toxicology and Chemistry. doi: 10.1002/etc.2738.
  • MC Arnold, TT Lindberg, YT Liu, KA Porter, H Hsu-Kim, DE Hinton, and RT Di Giulio. 2014. Bioaccumulation and speciation of selenium in fish and insects collected from a mountaintop removal coal mining-impacted stream in West Virginia. Ecotoxicology 23: 929-938.
  • M Auffan, CW Matson, JC Rose, M Arnold, O Proux, B Fayard, P Chaurand, MR Wiesner, JY Bottero, and RT Di Giulio. 2014. Salinity-dependent silver nanoparticles uptake and biotransformation in Atlantic killifish (Fundulus heteroclitus) embryos. Nanotoxicology 8:167-176.
  • TM Blickley, C Matson, WN Vreeland, D Rittschoff, RT Di Giulio, PD McClellan-Green. 2014. Dietary CdSe/ZnS quantum dot exposure in estuarine fish: bioavailability, oxidative stress responses, reproduction, and maternal transfer. Aquatic Toxicology 148: 27-49.

2013

  • BW Clark, AJ Bone, RT Di Giulio. 2013. Resistance to aryl-hydrocarbon-induced cardiac teratogenesis in F1 and F2 embryos of PAH-adapted Fundulus heteroclitus is strongly inherited despite reduced recalcitrance to induction of the AHR pathway. Environmental Science and Pollution Research. doi: 10.1007/s11356-013-2446-7). PMCID: 24374617.
  • MC Arnold, AR Badireddy, MR Wiesner, RT Di Giulio, JN Meyer. 2013. Cerium oxide nanoparticles are more toxic than equimolar bulk cerium oxide in Caenorhabditis elegans. Archives of Environmental Toxicology and Contamination 65: 224-233.
  • G Bozinovic, TL Sit, RT Di Giulio, LP Wills, MF Oleksiak. 2013. Genomic and physiological responses to strong selective pressure during late organogenesis: few gene expression changes found despite striking morphological differences. BMC Genomics 14: 779. doi: 10.1186/1471-2164-14-779. PMCID: 3835409.
  • BW Clark, EM Cooper, HM Stapleton, and RT Di Giulio. 2013. Compound- and mixture-specific differences in resistance to PAHs and PCB-126 among Fundulus heteroclits subpopulations throughout the Elizabeth River estuary (Virginia, USA). Environmental Science and Technology 47:10556-10556 (doi: 10.1021/es401604b. PMCID pending.
  • RT Di Giulio, MC Newman. Ecotoxicology. 2013. pp. 1275-1303 in Klaassen, C.D., ed. Casarett and Doull’s Toxicology. The Basic Science of Poisons, 8th edition. McGraw-Hill, New York, 1454 pp.
  • LVT Garner, DR Brown, and RT Di Giulio. 2013. The role of zebrafish (Danio rerio) AHR1 isoforms in PAH- and PCB-126 induced toxicity. Aquatic Toxicology 142/143: 336-346. PMCID: 3837554.
  • C Levard, EM Hotze, BP Colman, L Truong, X Yang, A Bone, GE Brown, RL Tanguay, RT Di Giulio, ES Bernhardt, JN Meyer, MR Wiesner, GV Lowry. 2013. Sulfidation and chlorination of silver nanoparticles: natural antidote to their ecotoxicity. Environmental Science and Technology 47:13440-13448. doi: 10.1021/es403527n.
  • EA Turner, GL Kroeger, MH Arnold, BLM Thornton, RT Di Giulio, and JN Meyer. 2013. Assessing different mechanisms of toxicity in mountaintop removal/valley fill coal mining-affected watershed samples using Caenorhabditis  elegans. PLoS One 8 (9): 375329.
  • A Vengosh, TT Lindberg, BR Merola, L Ruhl, NR Warner, A White, GS Dwyer, RT Di Giulio. 2013. Isotopic imprints of mountaintop mining contaminants. Environmental Science and Technology 47:10041-10048. doi: 10.1021/es4012959.
  • B Zhao, JES Bohonowych, A Timme-Laragy, D Jung, AA Affatato, RH Rice, RT Di Giulio, and MS Denison. 2013. Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. PLoS ONE 8(2): e56860. doi: 10.1371/journal.pone.0056860. PMCID pending.

2012

  • AJ Bone, BP Colman, AP Gondikas, KM Newton, KH Harrold, RM Cory, JM Unrine, SJ Klaine, CW Matson, RT Di Giulio. 2012. Biotic and abiotic interactions in aquative microcosms determine fate and toxicitiy of Ag nanoparticles: Part 2-Toxicity and Ag Speciation. Environmental Science & Technology. doi: 10.1021/es204683m.
  • JM Unrine, BP Colman, AJ Bone, AP Gondikas, CW Matson. 2012. Biotic and abiotic interactions in aquative microcosms determine fate and toxicitiy of Ag nanoparticles: Part 1. Aggregation and Dissolution.  Environmental Science & Technology. doi: 10.1021/es204682q
  • BW Clark, RT Di Giulio. 2012. Fundulus heteroclitus adapted to PAHs are cross-resistant to multiple insecticides. Ecotoxicology. doi: 10.1007/s10646-011-0807-x.
  • LVT Garner, RT Di Giulio. 2012. Glutathione transferase pi class 2 (GSTp2) protects against the cardiac deformities caused by exposure to PAHs but not PCB-126 in zebrafish embryos. Comparative Biochemistry and Physiology C – Toxicology and Pharmacology. doi 10.1016/j.cbpc.2012.01.007.

2011

  • T. Ty Lindberg, ES Bernhardt, R Bier, AM Helton, RB Merola, A Vengosh, RT Di Giulio. 2011. Cumulative impacts of mountaintop mining on an Appalachian watershed. PNAS, vol. 108 no 52, pp. 20929-20934.
  • D Jung, CW Matson, LB Collins, G Laban, HM Stapleton, JW Bickham, JA Swenberg, and RT Di Giulio. 2011. Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia. Ecotoxicology, vol. 20 no 8, pp. 1890-1899.
  • L Van Tiem, RT Di Giulio. 2011. AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE- and ARE-associated gene induction in zebrafish (Danio rerio). Toxicology and Applied Pharmacology, vol. 254 no. 3, pp. 280-287.

2010

  • EM Cooper, HM Stapleton, CW Matson, RT Di Giulio, AJ Schuler. 2010. Ultraviolet treatment and biodegradation of dibenzothiophene: Identification and toxicity of products. Environmental Toxicology and Chemistry, vol. 29 no. 11, pp. 2409-16 [doi]  [abs].
  • LP Wills, D Jung, K Koehrn, S Zhu, KL Willett, DE Hinton, RT Di Giulio. 2010. Comparative chronic liver toxicity of benzo[a]pyrene in two populations of the atlantic killifish (Fundulus heteroclitus) with different exposure histories. Environmental Health Perspectives, vol. 118 no. 10, pp. 1376-81 [doi]  [abs].
  • BW Clark, CW Matson, D Jung, RT Di Giulio. 2010. AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic killifish (Fundulus heteroclitus). Aquatic Toxicology, vol. 99 no. 2, pp. 232-40 [doi]  [abs].
  • LP Wills, CW Matson, CD Landon, RT Di Giulio. 2010. Characterization of the recalcitrant CYP1 phenotype found in Atlantic killifish (Fundulus heteroclitus) inhabiting a Superfund site on the Elizabeth River, VA. Aquatic Toxicology, vol. 99 no. 1, pp. 33-41 [doi]  [abs].
  • SE Hunter, D Jung, RT Di Giulio, JN Meyer. 2010. The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number., Methods, vol. 51 no. 4, pp. 444-51 [doi]  [abs].
  • D Jung and RT Di Giulio. 2010. Identification of mitochondrial cytochrome P450 induced in response to polycyclic aromatic hydrocarbons in the mummichog (Fundulus heteroclitus), Comparative Biochemistry and Physiology C – Toxicology and Pharmacology, vol. 151 no. 1, pp. 107-112 [doi]  [abs].
  • D Il’yasova, I Spasojevich, F Wang, AA Tolun, K Base, SP Young, PK Marcom, J Marks, G Mixon, RT DiGiulio, and DS Millington. 2010. Urinary biomarkers of oxidative status in a clinical model of oxidative assault. Cancer Epidemiology Biomarkers and Prevention, vol. 19, pp. 1506-1510 .

2009

  • D Jung, Y Cho, LB Collins, JA Swenberg, RT Di Giulio. 2009. Effects of benzo{[}a]pyrene on mitochondrial and nuclear DNA damage in Atlantic killifish (Fundulus heteroclitus) from a creosote-contaminated and reference site. Aquatic Toxicology, vol. 95 no. 1, pp. 44-51 [doi]  [abs].
  • MR Wiesner, GV Lowry, KL Jones, MF Hochella, Jr., RT Di Giulio, E Casman, ES Bernhardt. 2009. Decreasing Uncertainties in Assessing Environmental Exposure, Risk, and Ecological Implications of Nanomaterials, Environmental Ccience and Technology, vol. 43 no. 17, pp. 6458-6462 [doi] .
  • CR Fleming, SM Billiard, RT Di Giulio. 2009. Hypoxia inhibits induction of aryl hydrocarbon receptor activity in topminnow hepatocarcinoma cells in an ARNT-dependent manner. Comparative Biochemistry and Physiology C – Toxicology and Pharmacology, vol. 150 no. 3, pp. 383-389 [doi]  [abs].
  • AR Timme-Laragy, LA Van Tiem, EA Linney, RT Di Giulio. 2009. Antioxidant Responses and NRF2 in Synergistic Developmental Toxicity of PAHs in Zebrafish, TOXICOLOGICAL SCIENCES, vol. 109 no. 2, pp. 217-227 [doi]  [abs].
  • LP Wills, S Zhu, KL Willett, RT Di Giulio. 2009. Effect of CYP1A inhibition on the biotransformation of benzo{[}a]pyrene in two populations of Fundulus heteroclitus with different exposure histories. Aquatic Toxicology, vol. 92 no. 3, pp. 195-201 [doi]  [abs].
  • D Jung, Y Cho, JN Meyer, RT Di Giulio. 2009. The long amplicon quantitative PCR for DNA damage assay as a sensitive method of assessing DNA damage in the environmental model, Atlantic killifish (Fundulus heteroditus). Comparative Biochemistry and Physiology C – Toxicology and Pharmacology, vol. 149 no. 2, Sp. Iss. SI, pp. 182-186 [doi]  [abs].
  • D Il’yasova, G Mixon, F Wang, J Marks, I Spasojevich, N Crafft, F Arredondo, and RT Di Giulio, Epidemiological markers of oxidative stress: pilot validation study. Bioamrkers, 14:321-325. (2009) .
  • AR Timme-Laragy, PD Noyes, DR Buhler, and RT Di Giulio. 2008. CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio). Marine Environmental Research, vol. 66 no. 85-87.

2008

  • CW Matson, AR Timme-Laragy, RT Di Giulio. 2008. Fluoranthene, but not benzo[a]pyrene, interacts with hypoxia resulting in pericardial effusion and lordosis in developing zebrafish. Chemosphere, vol. 74, pp. 149-154.
  • CW Matson, BW Clark, MJ Jenny, CR Fleming, MEHahn, RT Di Giulio. 2008. Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental model. Aquatic Toxicol, pp. 289-295.
  • C Larose, R Canuel, M Lucotte, P Spear, RT Di Giulio. 2008. Toxicological effects of methylmercury on walleye (Sander vitreus) and perch (Perca flavescens) from lakes of the boreal forest. Comparative Biochem & Physiol, vol. 147C, pp. 139-149.
  • JES Bohonowych, B Zhao, AR Timme-Laragy, D Jung, RT Di Giulio, MS Denison. 2008. Newspapers and newspaper inks contain agonists for the AH receptor. Toxicological Sciences, vol. 102, pp. 278-290.
  • SM Billiard, JN Meyer, DM Wassenberg, PV Hodson, RT Di Giulio. 2008. Nonadditive effects of PAHs on early vertebrate development: mechanisms and implications for risk assessment. Toxicological Sciences, vol. 105, pp. 5-23.
  • TP Augspurger, DE Tillitt, SJ Bursian, SD Fitzgerald, DE Hinton, RT Di Giulio. 2008. Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the wood duck (Aix sponsa). Archives of Environmental Contamination and Toxicology, vol. 55, pp. 659-669.
  • TP Augspurger, KR Echols, PH Peterman, TW May, CE Orazio, DE Tillitt, RT Di Giulio. 2008. Accumulation of environmental contaminants in wood duck (Aix sponsa) eggs with emphasis on 2,3,7,,8-tetrachlordibenzo-p-dioxin equivalents. Archives of Environmental Contamination and Toxicology, vol. 55, pp. 670-682.

2002-2007

  • AR Timme-Laragy, CJ Cockman, CW Matson, RT Di Giulio. 2007. Synergistic upregulation of AHR regulated genes in developmental toxicity of a polycyclic aromatic hydrocarbon mixture to zebrafish. Aquatic Toxicology, vol. 85 no. 4, pp. 241-250.
  • M Rau Embry, SM Billiard, RT Di Giulio. 2006. Lack of p53 induction in fish cells by model chemotherapeutics. Oncogene, vol. 25, pp. 2004-2010.
  • SM Billiard, AR Timme-Laragy, DM Wassenberg, C Cockman, RT Di Giulio. 2006. The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Toxicological Sciences, vol. 92, pp. 526-536.
  • DM Wassenberg, A Nerlinger, L Battle, RT Di Giulio. 2005. Effects of the PAH-heterocycles, carbazole and dibenzothiophene, on invivo and invitro CYP1A activity and PAH-derived embryotoxicity. Environmental Toxicology and Chemistry, vol. 24, pp. 2526-2532.
  • AR Timme-Laragy, JN Meyer, RA Waterland, RT Di Giulio. 2005. Analysis of CpG methylation in the killifish CYP1A promoter. Comparative Biochemistry and Physiology, Part C, vol. 141, pp. 406-411.
  • JN Meyer, DC Volz, JH Freedman, RT Di Giulio. 2005. Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary. Aquatic Toxicology, vol. 73, pp. 327-34.
  • DM Wassenberg, RT Di Giulio. 2004. Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus, Environmental Health Perspectives, vol. 112, pp. 1658-1664.
  • DM Wassenberg, RT Di Giulio. 2004. Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors. Marine Environmental Research, vol. 58, pp. 163-168.
  • LR Bacanskas, J Whitaker, RT Di Giulio. 2004. Oxidative stress in two populations of killifish (Fundulus heteroclitus) with differing contaminant exposure histories. Marine Environmental Research, vol. 58, pp. 597-601.
  • MA Rau, J Whitaker, JH Freedman, RT Di Giulio. 2204. Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants. Comparative Biochemistry and Physiology, vol. 137C, pp. 335-342.
  • JN Meyer, RT Di Giulio. 2003. Genetic adaptation and associated fitness tradeoffs in killifish (Fundulus heteroclitus) inhabiting a contaminated estuary. Ecological Applications, vol. 13, pp. 490-503 .
  • JN Meyer, DM Wassenberg, SI Karchner, ME Hahn, RT Di Giulio. 2003. Expression and inducibility of aryl hydrocarbon receptor (AHR) pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environmental Toxicology and Chemistry, vol. 22, pp. 2337-2343.
  • JN Meyer, J.D. Smith, G.W. Winston, and R.T. Di Giulio, Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses, Aquatic Toxicology, vol. 65 (2003), pp. 377-395 .
  • JN Meyer, D. Nacci, and R.T. Di Giulio, Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments, Toxicological Sciences, vol. 68 (2002), pp. 69-81 .
  • JN Meyer, RT Di Giulio. 2002. Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA. Marine Environmental Research, vol. 54, pp. 621-626.
  • DM Wassenberg, E Swails, RT Di Giulio. 2002. Effects of combined exposures to benzo[a]pyrene and 3,3′,4,4′,5-pentachlorobiphenyl on Fundulus heteroclitus, Marine Environmental Research, vol. 54, pp. 279-283 .

Books Published

  • The Toxicology of Fishes, edited by Di Giulio, R.T., and D.E. Hinton (2008), Taylor and Francis, New York.
  • Genomic Approaches for Cross-Species Extrapolations in Toxicology, edited by Benson, W.H., and R.T. Di Giulio (2007), Taylor and Francis, New York .
  • Interconnections between Human Health and Ecological Integrity, edited by Di Giulio, R.T., and W.H. Benson (2002), SETAC Press, Pensacola, FL. .
  • Reproductive and Developmental Effects of Contaminants in Oviparous Vertebrates, edited by Di Giulio, R.T., and D.E. Tillitt (1999), SETAC Press, Pensacola, FL .
  • Interconnections Between Human and Ecosystem Health, edited by Di Giulio, R.T., and E. Monosson (1996), Chapman and Hall, London .

Book Chapters

  • JM Unrine, OV Tsyusko, RT Di Giulio. Primer on ecotoxicology with special considerations for manufactured nanomaterials. In: M. Wiesner and J.-Y. Bottero, Environmental Nanotechnology, 2nd Edition, McGraw-Hill, New York.  (In Press)
  • MJ Carvin, RT Di Giulio.  Oxidative stress responses in aquatic and marine fishes. In Roberts, S.M., J. Kehrer and O. Klotz, eds. Studies on Experimental Toxicology and Pharmacology. (2015) Springer, New York.
  • RT Di Giulio and MC Newman. Ecotoxicology, in Klaassen, C.D., ed. Casarett and Doull’s Toxicology. The Basic Science of Poisons, 6th edition (2013), McGraw-Hill .
  • RT Di Giulio and JN Meyer. Reactive oxygen species and oxidative stress, in The Toxicology of Fishes, edited by Di Giulio, R.T., and D.E. Hinton (2008), pp. 273-324, CRC Press, Taylor and Francis Group, New York.
  • JM Rotchell,  DE Hinton, MR Miller, RT Di Giulio and GK Ostrander. Chemical carcinogenesis in fishes, in Di Giulio, R.T., and D.E. Hinton, eds. The Toxicology of Fishes (2008), CRC Press, Taylor and Francis, New York .
  • D Nacci, L Coiro, DM Wassenberg, and RT Di Giulio. A non-destructive technique to measure cytochrome P4501A enzyme activity in living embryos of the estuarine fish Fundulus heteroclitus, in Techniques in Aquatic Toxicology, edited by Ostrander, G.K., vol. 2 (2005), pp. 209-226, CRC Press, Boca Raton, FL.
  • D Schlenk and RT Di Giulio. Biochemical responses as indicators of aquatic ecosystem health, in Biological Indicators of Aquatic Ecosystem Stress, edited by S.M. Adams (2002), pp. 13-422, American Fisheries Society, Bethesda, MD. .