Neurobehavioral Toxicity Core


Neurobehavioral Toxicity Core (NBTC)

While our research projects are trying to understand how exposures affect health, how can we actually know if a chemical affects brain development and leads to altered behavior and brain function?

The NBTC provides information on the consequences of exposures to chemicals like pesticides, PAH’s, and flame retardants using models such as zebrafish, killifish, rats, and C. elegans. They determine how these chemicals are toxic to the brain and nervous system by looking at several pathways and biological processes.

Animals exposed to chemicals in Projects 1, 2, 3, and 4 perform tests to assess their sensory and motor responses, cognitive function, and emotional function and provide outcome measures that apply to humans.

For an example of a neurobehavioral test conducted in zebrafish, read this blog post by Dr. Lilah Glazer.

Investigators

Dr. Edward Levin, Principal Investigator

Andrew Hawkey, Ph.D, Postdoctoral Research Associate