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2012

Clark, Bryan W. and Richard T. Di Giulio. 2012. Fundulus heteroclitus adapted to PAHs are cross-resistant to multiple insecticides. Ecotoxicology. 21, Number2:465-474. doi:10.1007/s10646-011-0807-x

Van Tiem, Lindsey A. and Richard T. Di Giulio. 2012. Glutathione s-transferase pi class 2 (GSTp2) protects against the cardiac deformities caused by exposure to PAHs but not PCB-126 in zebrafish embryos. Comparative Biochemistry and Physiology (accepted). PMC Joumal – In Process NIHMS350339. Comparative Biochemistry and Physiology. doi:10.1016/j.cbpc.2012.01.007 (accepted for publication)

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2011

Ela, Wendell P., David L. Sedlak, M. Barlaz, Heather F. Henry, D. Muir, D. Swackhamer, E. Weber, Robert G. Arnold, P. Lee Ferguson, Jennifer A. Field, Edward T. Furlong, John P. Giesy, Rolf Ulrich Halden, T. Henry, R. Hites, Keri C. Hornbuckle, P. Howard, Richard G. Luthy, A. Meyer, A. Eduardo Saez, F. vom Saal, Christopher Vulpe, and Mark R. Wiesner. 2011. Workshop Summary: Toward Identifying the Next Generation of Superfund and Hazardous Waste Site Contaminants. . http://ehp03.niehs.nih.gov/article/info%3Adoi%2F10.1289%2Fehp.1002497

Fleming, Carrie R. and Richard T. Di Giulio. 2011. The role of CYP1A inhibition in the embryotoxic interactions between hypoxia and polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures in zebrafish (Danio rerio). Ecotoxicology. 20:1300-1314. doi:10.1007/s10646-011-0686-1

Jung, Dawoon, Cole W. Matson, Leonard B. Collins, Geoff Laban, Heather Stapleton, John W. Bickham, James A. Swenberg, and Richard T. Di Giulio. 2011. Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia. Ecotoxicology. 20:1890-1899. doi:10.1007/s10646-011-0727-9

Levin, Edward D. 2011. Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development. Reviews in the Neurosciences. 22:75-84.

Levin, Edward D., Ann Petro, Sue Donerly, Elwood Linney, Damiyon Sledge, and Stephanie Roach. 2011. Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish. Neurotoxicology and Teratology. 33:668-673. doi:10.1016/j.ntt.2011.06.004

Powers, C., Edward D. Levin, Fredric J. Seidler, and Theodore A. Slotkin. 2011. Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes. Neurotoxicology and Teratology. 33:329-332. doi:10.1016/j.ntt.2010.10.006

Seidler, Frederic J. and Theodore A. Slotkin. 2011. Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: Effects of organophosphates are distinct from those of glucocorticoids. Brain Research Bulletin. 85:225-230. doi:10.1016/j.brainresbull.2011.03.021

Sledge, Damiyon, J. Yen, Terrell Morton, Laura Dishaw, Ann Petro, Sue Donerly, Elwood Linney, and Edward D. Levin. 2011. Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. Neurotoxicology and Teratology. 33:742-751. doi:10.1016/j.ntt.2011.06.005

Slotkin, Theodore A. 2011. Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity?. Reproductive Toxicology. 31:297-301. doi:10.1016/j.reprotox.2010.07.012

Slotkin, Theodore A., Frederic J. Seidler, and Elliot R. Spindel. 2011. Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: Amelioration by Vitamin C. Neurotoxicology and Teratology. 33:431-434. doi:10.1016/j.ntt.2011.02.001

Whitehead, Andrew, Fernando Galvez, Shu J. Zhang, Larissa M. Williams, and Marjorie F. Oleksiak. 2011. Functional Genomics of Physiological Plasticity and Local Adaptation in Killifish. Journal of Heredity. 102:499-511. doi:10.1093/jhered/esq077

Yen, J., Sue Donerly, Edward D. Levin, and Elwood Linney. 2011. Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicology and Teratology. 33:735-741. doi:10.1016/j.ntt.2011.10.004

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2010

Adigun, A., I.T. Ryde, Fredric J. Seidler, and Theodore A. Slotkin. 2010. Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells. Brain Research. 1329:36-44. doi:10.1016/j.brainres.2010.03.025

Adigun, A., Nicola Wrench, and Theodore A. Slotkin. 2010. Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion. Environmental Health Perspectives. 118(2):210-215. doi:10.1289/ehp.0901237

Alexeyenko, A., Deena M. Wassenberg, E.K. Lobenhofer, J. Yen, Elwood Linney, E. Sonnhammer, and Joel N. Meyer. 2010. Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity. PLoS ONE. 5(5):e10465. doi:10.1371/journal.pone.0010465

Boyd, Windy, Tracey Crocker, Ana Rodriguez, Maxwell Leung, D. Lehmann, Jonathan H. Freedman, Ben Van Houten, and Joel N. Meyer. 2010. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 683(1-2):57-67. doi:10.1016/j.mrfmmm.2009.10.008

Clark, Bryan W., Cole W. Matson, Dawoon Jung, and Richard T. Di Giulio. 2010. AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic killifish (Fundulus heteroclitus). Aquatic Toxicology. 99(2):232-240. doi:10.1016/j.aquatox.2010.05.004

Cooper, Ellen, Heather Stapleton, Cole Matson, Richard Di Giulio, and Andrew Shuler. 2010. Ultraviolet treatment and biodegradation of dibenzothiophene: Identification and toxicity of products. Environmental Toxicology and Chemistry. 29(11):2409-2416. doi: 10.1002/etc.312

Hunter, S., Dawoon Jung, Richard T. Di Giulio, and Joel N. Meyer. 2010. The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number. Methods. 51:444-451. doi:10.1016/j.ymeth.2010.01.033

Kim, B., M.L. Turski, Y. Nose, M. Casad, Howard A. Rockman, and Dennis Thiele. 2010. Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs. Cell Metabolism. 11(5):353-63. doi:10.1016/j.cmet.2010.04.003

Lassiter, T.L., I.T. Ryde, Edward D. Levin, Fredric J. Seidler, and Theodore A. Slotkin. 2010. Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits. Brain Research Bulletin. 81:85-91. doi:10.1016/j.brainresbull.2009.07.002

Leung, Maxwell, Jared V. Goldstone, Windy Boyd, Jonathan H. Freedman, and Joel N. Meyer. 2010. Caenorhabditis elegans Generates Biologically Relevant Levels of Genotoxic Metabolites from Aflatoxin B-1 but Not Benzo a pyrene In Vivo. Toxicological Sciences. 118:444-453. doi:10.1093/toxsci/kfq295

Levin, Edward D., Olga A. Timofeeva, L. Yang, I.T. Ryde, Nicola Wrench, Frederic J. Seidler, and Theodore A. Slotkin. 2010. Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging. Behav. Brain Research. 208:319-327. doi:10.1016/j.bbr.2009.11.007

Meyer, Joel N. 2010. QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology. Ecotoxicology. 19:804-11. doi:10.1007/s10646-009-0457-4

Powers, C., Nicola Wrench, I.T. Ryde, A.A. Smith, Fredric J. Seidler, and Theodore A. Slotkin. 2010. Silver impairs neurodevelopment: studies in PC12 cells. Environmental Health Perspectives. 118:73-9. doi:10.1289/ehp.0901149

Powers, C., J. Yen, Elwood Linney, and Fredric J. Seidler. 2010. Silver exposure in developing zebrafish (Danio rerio): Persistent effects on larval behavior and survival. Neurotoxicology and Teratology. 32:391-397. doi:10.1016/j.ntt.2010.01.009

Slotkin, Theodore A. and Frederic J. Seidler. 2010. Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an In vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PCI2 cells. Brain Research. 1353:36-52. doi:10.1016/j.brainres.2010.07.073

Slotkin, Theodore A. and Frederic J. Seidler. 2010. Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an In vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PCI2 cells. Brain Research. 1353:36-52. doi:10.1016/j.brainres.2010.07.073

Slotkin, Theodore A. and Fredric J. Seidler. 2010. Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss. Neurotoxicology and Teratology. 32:124-31. doi:10.1016/j.ntt.2009.12.001

Slotkin, Theodore A., D. Lobner, and Fredric J. Seidler. 2010. Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants. Brain Research Bulletin. 83:76-83. doi:10.1016/j.brainresbull.2010.06.010

Wills, L., Dawoon Jung, K. Koehrn, S. Zhu, David E. Hinton, and Richard T. Di Giulio. 2010. Comparative Chronic Liver Toxicity of Benzo a pyrene in Two Populations of the Atlantic Killifish (Fundulus heteroclitus) with Different Exposure Histories. Environmental Health Perspectives. 118:1376-1381. doi:10.1289/ehp.0901799

Kumanyika, Shiriki K, Parker, L., Sim, Leslie,. 2010. Bridging the Evidence Gap in Obesity Prevention: A Framework to Inform Decision Making. Editors; Committee on an Evidence Framework for Obesity Prevention Decision Making; Institute of Medicine. . http://www.nap.edu/catalog.php?record_id=12847

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2009

Cerutti, D.T., Edward D. Levin, Donnie Eddins, Ann Petro, and Paul Williams. 2009. Nicotine effects on learning in zebrafish: the role of dopaminergic systems. Psychopharmacology. 202(1-3):103-9. doi:10.1007/s00213-008-1287-4

Jung, Dawoon, Youngeun Cho, L.B. Collins, James A. Swenberg, and Richard T. Di Giulio. 2009. Effects of benzo[a]pyrene on mitochondrial and nuclear DNA damage in Atlantic killifish (Fundulus heteroclitus) from a creosote-contaminated and reference site. Aquatic Toxicology. 95(1):44-51. doi:10.1016/j.aquatox.2009.08.003

Levin, Edward D., Michael Aschner, Ulrike Heberlein, Douglas Ruden, Kathleen A. Welsh-Bohmer, Selena Bartlett, Karen Berger, Lang Chen, Ammon B. Corl, Donnie Eddins, Rachael French, Kathleen M. Hayden, Kirsten Helmcke, Helmut VB Hirsch, Elwood Linney, Greg Lnenicka, Grier P. Page, Debra Possidente, Bernard Possidente, and Annette Kirshner. 2009. Genetic aspects of behavioral neurotoxicology. NeuroToxicology. 30(5):741-53. doi:10.1016/j.neuro.2009.07.014

Slotkin, Theodore A. and Fredric J. Seidler. 2009. Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. Brain Research. 1263:23-32. doi:10.1016/j.brainres.2009.01.049

Slotkin, Theodore A., Nicola Wrench, I.T. Ryde, T.L. Lassiter, Edward D. Levin, and Fredric J. Seidler. 2009. Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood. Neurotoxicology and Teratology. 31(6):390-9. doi:10.1016/j.ntt.2009.07.003

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2008

Bencan, Z. and Edward D. Levin. 2008. The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish. Physiology and Behavior. 95(3):408-12. doi:10.1016/j.physbeh.2008.07.009

Billiard, Sonya M., Joel N. Meyer, Deena M. Wassenberg, Peter V. Hodson, and Richard T. Di Giulio. 2008. Nonadditive effects of PAHs on early vertebrate development: mechanisms and implications for risk assessment. Toxicological Sciences. 105(1):5-23. doi:10.1093/toxsci/kfm303

Carney, Michael W., Kyle Erwin, Ron Hardman, Bonny Yuen, David C. Volz, David E. Hinton, and Seth W. Kullman. 2008. Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos. Marine Pollution Bulletin. 57(6-12):255-66. doi:10.1016/j.marpolbul.2008.02.036

Lassiter, T.L., I.T. Ryde, E.A. MacKillop, Kathleen K. Brown, Edward D. Levin, Fredric J. Seidler, and Theodore A. Slotkin. 2008. Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood. Environmental Health Perspectives. 116:1456-1462. doi:10.1289/ehp.11673

Matson, Cole W., Bryan W. Clark, M.J. Jenny, Carrie R. Fleming, Mark E. Hahn, and Richard T. Di Giulio. 2008. Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental model. Aquatic Toxicology. 87(4):289-95. doi:10.1016/j.aquatox.2008.02.010

Mattie, Michael D., Matthew K. McElwee, and Jonathan H. Freedman. 2008. Mechanism of copper-activated transcription: activation of AP-1, and the JNK/SAPK and p38 signal transduction pathways. Journal of Molecular Biology. 383(5):1008-18. doi:10.1016/j.jmb.2008.08.080

Miranda, Marie Lynn, M. Alicia Overstreet, and D. Kim. 2008. A framework for widespread replication of a highly spatially resolved childhood lead exposure risk model. Environmental Health Perspectives. 116(12):1735-1739. doi:10.1289/ehp.11540

Roegge, Cindy S., Olga A. Timofeeva, Fredric J. Seidler, Theodore A. Slotkin, and Edward D. Levin. 2008. Developmental diazinon neurotoxicity in rats: later effects on emotional response. Brain Research Bulletin. 75:168-172.

Slotkin, Theodore A. and Fredric J. Seidler. 2008. Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. Toxicology and Applied Pharmacology. 233(2):211-9. doi:10.1016/j.taap.2008.08.020

Slotkin, Theodore A., Bethany E. Bodwell, Edward D. Levin, and Fredric J. Seidler. 2008. Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. Environmental Health Perspectives. 116(3):340-8. doi:10.1289/ehp.11005

Slotkin, Theodore A., Bethany E. Bodwell, I.T. Ryde, Edward D. Levin, and Fredric J. Seidler. 2008. Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood. Environmental Health Perspectives. 116(10):1308-14. doi:10.1289/ehp.11451

Slotkin, Theodore A., I.T. Ryde, Edward D. Levin, and Fredric J. Seidler. 2008. Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood. Brain Research Bulletin. 75(5):640-7. doi:10.1016/j.brainresbull.2007.10.008

Slotkin, Theodore A., Fredric J. Seidler, and F. Fumagalli. 2008. Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. Brain Research Bulletin. 76(4):424-38. doi:10.1016/j.brainresbull.2008.01.001

Slotkin, Theodore A., Fredric J. Seidler, I.T. Ryde, and Joseph Yanai. 2008. Developmental neurotoxicity of chlorpyrifos in an avian model: effects on acetylcholine and serotonin pathways. Neurotoxicology and Teratology.

Timme-Laragy, Alicia R., Pamela D. Noyes, Donald R. Buhler, and Richard T. Di Giulio. 2008. CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio). Marine Environmental Research. 66(1):85-7. doi:10.1016/j.marenvres.2008.02.030

Timofeeva, Olga A., Cindy S. Roegge, Fredric J. Seidler, Theodore A. Slotkin, and Edward D. Levin. 2008. Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. Neurotoxicology and Teratology. 30(1):38-45. doi:10.1016/j.ntt.2007.10.002

Timofeeva, Olga A., David Sanders, Kristen Seemann, Liwei Yang, Daniel Hermanson, Sam Regenbogen, Anita Kallepalli, Anit Rastogi, David Braddy, Corinne Wells, Charles Perraut, Fredric J. Seidler, Theodore A. Slotkin, Edward D. Levin, and Samantha Agoos. 2008. Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion. Brain Research Bulletin. 77(6):404-11. doi:10.1016/j.brainresbull.2008.08.019

West, Adrian K., Juan Hidalgo, Donnie Eddins, Edward D. Levin, and Michael Aschner. 2008. Metallothionein in the central nervous system: Roles in protection, regeneration and cognition. NeuroToxicology. 29(3):489-503. doi:10.1016/j.neuro.2007.12.006

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2007

Buznikov, Gennady A., Lyudmila A. Nikitina, L.M. Rakic, I. Milosevic, V.V. Bezuglov, Jean M. Lauder, and Theodore A. Slotkin. 2007. The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine. Brain Research Bulletin. 74(4):221-231.

Di Giulio, Richard T. and David E. Hinton, eds. 2007. The Toxicology of Fishes . Taylor & Francis, Boca Raton, FL.

Hinton, David E., H. Segner, DWT Au, Seth W. Kullman, and R.C. Hardman. 2007. Liver toxicity. In: The Toxicology of Fishes . Taylor & Francis, Boca Raton, FL.

Jameson, Ruth R., Fredric J. Seidler, and Theodore A. Slotkin. 2007. Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon and diazinon. Environmental Health Perspectives. 115:65-70.

Lassiter, Chris S. and Elwood Linney. 2007. Embryonic expression and steroid regulation of brain Aromatase (cyp19a1b) in zebrafish (Danio rerio). Zebrafish. 4(1):49-58.

Levin, Edward D., Z. Bencan, and D.T. Cerutti. 2007. Anxiolytic effects of nicotine in zebrafish. Physiology and Behavior. 90(1):54-8.

Ostrander, Gary K., Richard T. Di Giulio, David E. Hinton, M.R. Miller, and J.R. Rotchell. 2007. Chemical Carcinogensis. In: The Toxicology of Fishes . Taylor & Francis, Boca Raton, FL.

Shemer, Hilla and Karl G. Linden. 2007. Aqueous photodegradation and toxicity of the polycyclic aromatic hydrocarbons fluorene, dibenzofuran and dibenzothiophene. Water Research. 41(4):853-61.

Slotkin, Theodore A. and Fredric J. Seidler. 2007. Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Brain Research. 72:232-274.

Slotkin, Theodore A. and Fredric J. Seidler. 2007. Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats. Brain Research Bulletin. 73(4-6):301-9.

Slotkin, Theodore A. and Fredric J. Seidler. 2007. Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects. Reproductive Toxicology. 23(3):421-7.

Slotkin, Theodore A., E.A. MacKillop, I.T. Ryde, and Fredric J. Seidler. 2007. Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. Environmental Health Perspectives. 115:1306-1313.

Slotkin, Theodore A., E.A. MacKillop, I.T. Ryde, Charlotte A. Tate, and Fredric J. Seidler. 2007. Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine and divalent nickel. Environmental Health Perspectives. 115:93-101.

Slotkin, Theodore A., Fredric J. Seidler, and F. Fumagalli. 2007. Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environmental Health Perspectives. 115(6):909-16.

Timme-Laragy, Alicia R., C. Cockman, Cole W. Matson, and Richard T. Di Giulio. 2007. Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish. Aquatic Toxicology. 85(4):241-50.

Turski, M.L. and Dennis Thiele. 2007. Drosophila ctrl A functions as a copper transporter essential for development. Journal of Biological Chemistry. 282:24017-24026.

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2006

Arzuaga, Xabier, Deena M. Wassenberg, Richard T. Di Giulio, and Adria A. Elskus. 2006. The chlorinated AHR ligand 3,32,4,42,5-pentachlorobiphenyl (PCB126) promotes reactive oxygen species (ROS) production during embryonic development in the killifish (Fundulus heteroclitus). Aquatic Toxicology. 76(1):13-23.

Billiard, Sonya M., Alicia R. Timme-Laragy, Deena M. Wassenberg, C. Cockman, and Richard T. Di Giulio. 2006. The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Toxicological Sciences. 92:526-536.

Cerutti, D.T. and Edward D. Levin. 2006. Cognitive impairments models using complementary species. In: Animal Models of Cognitive Impairment. (). CRC Press, NY. pp.315-342.

Cook, J., Nancy D. Denslow, T. Iguchi, Elwood Linney, A. Miracle, Joseph R. Shaw, Mark R. Viant, and Timothy R. Zacharewski. 2006. “Omics” approaches in the context of environment toxicology. (In: Emerging Molecular and Computational Approaches for Cross-Species Extrapolations). Chapter 1in: Society of Environmental Toxicology and Chemistry (SETAC) Annual Meeting 2006. Washington, DC. pp.1-29.

Embry, Michelle Rau, Sonya M. Billiard, and Richard T. Di Giulio. 2006. Lack of p53 induction in fish cells by model chemotherapeutics. Oncogene. 25(14):2004-2010.

Jameson, Ruth R., Fredric J. Seidler, Dan Qiao, and Theodore A. Slotkin. 2006. Adverse Neurodevelopmental Effects of Dexamethasone Modeled in PC12 Cells: Identifying the Critical Stages and Concentration Thresholds for the Targeting of Cell Acquisition, Differentiation and Viability. Neuropsychopharmacology. 31(8):1647-1658.

Jameson, Ruth R., Fredric J. Seidler, Dan Qiao, and Theodore A. Slotkin. 2006. Chlorpyrifos Affects Phenotypic Outcomes in a Model of Mammalian Neurodevelopment: Critical Stages Targeting Differentiation in PC12 Cells. Environmental Health Perspectives. 114:667-672.
Levin, Edward D. and Jerry J. Buccafusco. 2006. Animal Models of Cognitive Impairment. (). CRC Press, NY.

Levin, Edward D., Charles Perraut, Ninitia Pollard, and Jonathan H. Freedman. 2006. Metallothionein expression and neurocognitive function in mice. Physiology and Behavior. 87(3):513-518.

Shemer, Hilla and Karl G. Linden. 2006. Degradation and by-product formation of diazinon in water during UV and UV/H₂O₂ treatment. Journal of Hazardous Materials. 136:553-559.

Shemer, Hilla and Karl G. Linden. 2006. Photolysis, oxidation and subsequent toxicity of a mixture of polycyclic aromatic hydrocarbons in natural waters. Journal of Photochemistry and Photobiology A: Chemistry. 187(2-3):186-195.

Slotkin, Theodore A. and Fredric J. Seidler. 2006. Anomalous regulation of B-adrenoceptor signaling in brain regions of the newborn rat. Brain Research. 1077(1):54-58.

Slotkin, Theodore A., Edward D. Levin, and Fredric J. Seidler. 2006. Comparative Developmental Neurotoxicity of Organophosphate Insecticides: Effects on Brain Development are Separable from Systemic Toxicity. Environmental Health Perspectives. 114(5):746-751.

Slotkin, Theodore A., Charlotte A. Tate, I.T. Ryde, Edward D. Levin, and Fredric J. Seidler. 2006. Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environmental Health Perspectives. 114:1542-1545.

Timme-Laragy, Alicia R., Edward D. Levin, and Richard T. Di Giulio. 2006. Developmental and behavioral effects of embryonic exposure to the polybrominated diphenylether mixture DE-71 in the killifish (Fundulus heteroclitus). Chemosphere. 62(7):1097-1104.

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2005

Aldridge, Justin E., Edward D. Levin, Fredric J. Seidler, and Theodore A. Slotkin. 2005. Developmental Exposure of Rats to Chlorpyrifos Leads to Behavioral Alterations in Adulthood, Involving Serotonergic Mechanisms and Resembling Animal Models of Depression. Environmental Health Perspectives. 113(5):527-531.

Aldridge, Justin E., Armando Meyer, Fredric J. Seidler, and Theodore A. Slotkin. 2005. Alterations in Central Nervous System Serotonergic and Dopaminergic Synaptic Activity in Adulthood after Prenatal or Neonatal Chlorpyrifos Exposure. Environmental Health Perspectives. 113(8):1027-1031.

Aldridge, Justin E., Armando Meyer, Fredric J. Seidler, and Theodore A. Slotkin. 2005. Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicology and Applied Pharmacology. 203(2):132-144.

Garcia, Stephanie J., Fredric J. Seidler, and Theodore A. Slotkin. 2005. Developmental neurotoxicity of chlorpyrifos: targeting glial cells. Environmental Toxicology and Pharmacology. 19(3):455-461.

Meyer, Armando, Fredric J. Seidler, Justin E. Aldridge, and Theodore A. Slotkin. 2005. Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos. Toxicology and Applied Pharmacology. 203(2):154-166.

Meyer, Joel N., David C. Volz, Jonathan H. Freedman, and Richard T. Di Giulio. 2005. Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary. Aquatic Toxicology. 73(4):327-341.

Nacci, Diane E., L. Coiro, Deena M. Wassenberg, and Richard T. Di Giulio. 2005. A non-destructive technique to measure cytochrome P4501A enzyme activity in living embryos of the estuarine fish Fundulus heteroclitus. Chapter Vol. 2 in: Techniques in Aquatic Toxicology. CRC Press, Inc., Boca Raton, FL. pp.209-226.

Qiao, Dan, Fredric J. Seidler, and Theodore A. Slotkin. 2005. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicology and Applied Pharmacology. 206(1):17-26.

Roy, Tara Sankar, Vikram Sharma, Fredric J. Seidler, and Theodore A. Slotkin. 2005. Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. Developmental Brain Research. 155(1):71-80.

Shemer, Hilla, Charles M. Sharpless, and Karl G. Linden. 2005. Photodegradation of 3,5,6-trichloro-2-pyridinol in aqueous solution. Water, Air & Soil Pollution. 168(1-4):145-155.

Slotkin, Theodore A. 2005. Developmental Neurotoxicity of Organophosphates: A Case Study of Chlorpyrifos. Chapter 21 in: Toxicity of Organophosphate and Carbamate Compounds. (Ramesh C. Gupta, ed). Elsevier Academic Press, San Diego, CA. pp.293-314.

Slotkin, Theodore A. and Fredric J. Seidler. 2005. The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. Developmental Brain Research. 158(1-2):115-119.

Slotkin, Theodore A., Kathleen K. Brown, and Fredric J. Seidler. 2005. Developmental Exposure of Rats to Chlorpyrifos Elicits Sex-Selective Hyperlipidemia and Hyperinsulinemia in Adulthood. Environmental Health Perspectives. 113(10):1291-1294. doi:10.1289/ehp.8133

Slotkin, Theodore A., Colleen A. Oliver, and Fredric J. Seidler. 2005. Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination. Developmental Brain Research. 157(2):172-180.

Slotkin, Theodore A., Charlotte A. Tate, Mandy M. Cousins, and Fredric J. Seidler. 2005. Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. Developmental Brain Research. 160(2):219-230.

Song, Min Ok and Jonathan H. Freedman. 2005. Activation of Mitogen Activated Protein Kinases by PCB126 (3,3′,4,4′,5-Pentachlorobiphenyl) in HepG2 Cells. Toxicological Sciences. 84(2):308-318.

Song, Min Ok and Jonathan H. Freedman. 2005. Expression of copper-responsive genes in HepG2 cells. Molecular and Cellular Biochemistry. 279(1-2):141-147.

Timme-Laragy, Alicia R., Joel N. Meyer, Robert A. Waterland, and Richard T. Di Giulio. 2005. Analysis of CpG methylation in the killifish CYP1A promoter. Comparative Biochemistry and Physiology – Part C: Toxicology & Pharmacology. 141(4):406-411.

Wassenberg, Deena M., Abby L. Nerlinger, Lauren P. Battle, and Richard T. Di Giulio. 2005. Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities. Environmental Toxicology and Chemistry. 24(10):2526-2532.

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2004

Aldridge, Justin E., Fredric J. Seidler, and Theodore A. Slotkin. 2004. Developmental Exposure to Chlorpyrifos Elicits Sex-Selective Alterations of Serotonergic Synaptic Function in Adulthood: Critical Periods and Regional Selectivity for Effects on the Serotonin Transporter, Receptor Subtypes, and Cell Signaling. Environmental Health Perspectives. 112(2):148-155.

Bacanskas, Lisa R., Julia Whitaker, and Richard T. Di Giulio. 2004. Oxidative stress in two populations of killifish (Fundulus heteroclitus) with differing contaminant exposure histories. Marine Environmental Research. 58(2-5):597-601. doi:10.1016/j.marenvres.2004.03.048

Craft, Elena S., Michelle Rau Embry, Richard T. Di Giulio, and Jonathan H. Freedman. 2004. Evidence for the role of p53 in metal-induced activation of metallothionein gene expression. In: Metal Ions in Biology and Medicine: Proceedings of the Eighth International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext Publishers, Montrouge, France.

Dolinoy, Dana C. and Marie Lynn Miranda. 2004. GIS Modeling of Air Toxics Releases from TRI-Reporting and Non-TRI-Reporting Facilities: Impacts for Environmental Justice. Environmental Health Perspectives. 112(17):1717-1724.

Embry, Michelle Rau, Julia Whitaker, Jonathan H. Freedman, and Richard T. Di Giulio. 2004. Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants. Comparative Biochemistry and Physiology – Part C: Toxicology & Pharmacology. 137(4):335-342.

Icenogle, Laura M., N. Channelle Christopher, W. Paul Blackwelder, D. Patrick Caldwell, Dan Qiao, Fredric J. Seidler, Theodore A. Slotkin, and Edward D. Levin. 2004. Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicology and Teratology. 26(1):95-101.

Izrael, Michal, Eddy A. Van der Zee, Theodore A. Slotkin, and Joseph Yanai. 2004. Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. Journal of Neuroscience Research. 78(4):499-507.

Levin, Edward D., Holly A. Swain, Sue Donerly, and Elwood Linney. 2004. Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior. Neurotoxicology and Teratology. 26(6):719-723.

Linney, Elwood and Ava J. Udvadia. 2004. Construction and detection of fluorescent germline transgenic zebrafish. Chapter Vol. 254 in: Methods in Molecular Biology, 2004. Humana Press, Inc, Louisville, KY. pp.271-288.

Linney, Elwood, Lucia Upchurch, and Sue Donerly. 2004. Zebrafish as a neurotoxicological model. Neurotoxicology and Teratology. 26(6):709-718.

Mattie, Michael D. and Jonathan H. Freedman. 2004. Copper-inducible transcription: regulation by metal- and oxidative stressresponsive pathways. American Journal of Physiology – Cell Physiology. 286(2):C293-C301.

Meyer, Armando, Fredric J. Seidler, Justin E. Aldridge, Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. 2004. Critical Periods for Chlorpyrifos-Induced Developmental Neurotoxicity: Alterations in Adenylyl Cyclase Signaling in Adult Rat Brain Regions after Gestational or Neonatal Exposure. Environmental Health Perspectives. 112(3):295-301.

Meyer, Armando, Fredric J. Seidler, and Theodore A. Slotkin. 2004. Developmental Effects of Chlorpyrifos Extend Beyond Neurotoxicity: Critical Periods for Immediate and Delayed-Onset Effects on Cardiac and Hepatic Cell Signaling. Environmental Health Perspectives. 112(2):170-178.

Qiao, Dan, Fredric J. Seidler, Yael Abreu-Villaca, Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. 2004. Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. Developmental Brain Research. 148(1):43-52.

Rhodes, M.C., Fredric J. Seidler, Dan Qiao, Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. 2004. Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. Toxicology and Applied Pharmacology. 195(2):203-217.

Roy, Tara Sankar, Fredric J. Seidler, and Theodore A. Slotkin. 2004. Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia. Developmental Brain Research. 148(2):197-206.

Slotkin, Theodore A. 2004. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicology and Applied Pharmacology. 198(2):132-151.

Slotkin, Theodore A. 2004. Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective. NeuroToxicology. 25(4):631-640.

Slotkin, Theodore A., Matthew C. Southard, Stacey J. Adam, Mandy M. Cousins, and Fredric J. Seidler. 2004. Alpha7 Nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos. Brain Research Bulletin. 64(3):227-235.

Wassenberg, Deena M. and Richard T. Di Giulio. 2004. Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in Fundulus heteroclitus. Environmental Health Perspectives. 112(17):1658-1664.

Wassenberg, Deena M. and Richard T. Di Giulio. 2004. Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors. Marine Environmental Research. 58(2-5):163-168.

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2003

Aldridge, Justin E., Fredric J. Seidler, Armando Meyer, Indira Thillai, and Theodore A. Slotkin. 2003. Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. Environmental Health Perspectives. 111(14):1736-1743.

Buznikov, Gennady A., Theodore A. Slotkin, and Jean M. Lauder. 2003. Sea urchin embryos and larvae as biosensors for neurotoxins. In: Current Protocals in Toxicology. John Wiley & Sons, NY. pp.1.6.1-1.6.24.

Cooper, E.M. and Dharni Vasudevan. 2003. Comparison of hydroxynaphthoic acid isomer sorption onto goethite: Batch, ATR-FTIR and Computational chemistry approaches. In: Proceedings of the 226^th ACS (American Chemical Society) National Meeting – Fall 2003. New York, NY.

Dam, K., Fredric J. Seidler, and Theodore A. Slotkin. 2003. Transcriptional biomarkers distinguish between vunerable periods for developmental neurotoxicity of chlorpyrifos: implications for toxicogenomics. Brain Research Bulletin. 59(4):261-265.

Garcia, S.J., Fredric J. Seidler, and Theodore A. Slotkin. 2003. Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities. Environmental Health Perspectives. 111(3):297-303.

Levin, Edward D., Elizabeth Chrysanthis, Kari Yacsin, and Elwood Linney. 2003. Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. Neurotoxicology and Teratology. 25(1):51-57.

Linney, Elwood and Ava J. Udvadia. 2003. Construction and detection of fluorescent germ-line transgenic zebrafish. In: Methods in Molecular Medicine. (). Humana Press,

Meyer, Armando, Fredric J. Seidler, Mandy M. Cousins, and Theodore A. Slotkin. 2003. Developmental Neurotoxicity Elicited by Gestational Exposure to Chlorpyrifos: When Is Adenylyl Cyclase a Target?. Environmental Health Perspectives. 111(16):1871-1876.

Meyer, Joel N. and Richard T. Di Giulio. 2003. Heritable adaptation and fitness costs in killifish (Fundulus heteroclitus) inhabiting a polluted estuary. Ecological Applications. 13(2):490-503.

Meyer, Joel N., Jim D. Smith, Gary W. Winston, and Richard T. Di Giulio. 2003. Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses. Aquatic Toxicology. 65(4):377-395. doi:10.1016/j.aquatox.2003.06.001

Meyer, Joel N., Deena M. Wassenberg, Sibel I. Karchner, Mark E. Hahn, and Richard T. Di Giulio. 2003. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environmental Toxicology and Chemistry. 22(10):2337-2343.

Nikitina, Lyudmila A., Gennady A. Buznikov, Jean M. Lauder, Fredric J. Seidler, and Theodore A. Slotkin. 2003. The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity. Environmental Health Perspectives. 111(14):536-544.

Qiao, Dan, Fredric J. Seidler, J.D. Violin, and Theodore A. Slotkin. 2003. Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. Developmental Brain Research. 147(1-2):183-190.

Seidler, Fredric J., Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. 2003. Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. Environmental Health Perspectives. 111(4):536-544.

Udvadia, Ava J. and Elwood Linney. 2003. Windows into development: historic, current, and future perspectives on transgenic zebrafish. Developmental Biology. 256(1):1-17.

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2002

Adams, T.K., N. Saydam, F. Steiner, W. Schaffner, and Jonathan H. Freedman. 2002. Activation of gene expression by metal-responsive signal transduction pathways. Environmental Health Perspectives. 110(5):813-817.

Garcia, S.J., Fredric J. Seidler, and Theodore A. Slotkin. 2002. Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein. Developmental Brain Research. 133(2):151-161.

Kimura, Yoshishige, Ethan E. Corcoran, Koh Eto, Keiko Gengyo-Ando, Masa-aki Muramatsu, Ryoji Kobayashi, Jonathan H. Freedman, Shohei Mitani, Masatoshi Hagiwara, Anthony R. Means, and Hiroshi Tokumitsu. 2002. A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO Journal. 3:962-966.

Lassiter, Chris S., B. Kelley, and Elwood Linney. 2002. Genomic structure and embryonic expression of estrogen receptor beta a (ERBa) in zebrafish (Danio rerio). Gene. 292(1-2):141-151.

Levin, Edward D., Nii Addy, Avanti Baruah, Alana Elias, N. Channelle Christopher, Fredric J. Seidler, and Theodore A. Slotkin. 2002. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicology and Teratology. 24(6):733-741.

Liao, V.H-C and Jonathan H. Freedman. 2002. Differential display analysis of gene expression in invertebrates. Cellular and Molecular Life Sciences. 59:1256-1263.

Liao, V.H-C, J. Dong, and Jonathan H. Freedman. 2002. Molecular characterization of a novel, cadmium-inducible gene from Caenorhabditis elegans. Journal of Biological Chemistry. 277:42049-42059.

Mattie, Michael D. and Jonathan H. Freedman. 2002. Copper Inducible Gene Expression Regulated by Metals and Oxidative Stress Responsive Pathways. Trace Elements in Medicine (In Russian). 3:46.

Mattie, Michael D. and Jonathan H. Freedman. 2002. Copper Inducible Gene Expression Regulated by Metals and Oxidative Stress Responsive Pathways. In: Metal Ions in Biology and Medicine: Proceedings of the Seventh International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext Publishers, Reims, France. pp.108-112.

Meyer, Joel N. and Richard T. Di Giulio. 2002. Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA. Marine Environmental Research. 54(3-5):621-626.

Meyer, Joel N., Diane E. Nacci, and Richard T. Di Giulio. 2002. Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments. Toxicological Sciences. 68(1):69-81.

Miranda, Marie Lynn, Dana C. Dolinoy, and M. Alicia Overstreet. 2002. Mapping for Prevention: GIS Models for Directing Childhood Lead Poisoning Prevention Programs. Environmental Health Perspectives. 110(9):947-953.

Saydam, N., T.K. Adams, F. Steiner, W. Schaffner, and Jonathan H. Freedman. 2002. Regulation of Metallothionein Transcription by the metal responsive transcription factor MTF-1. Identification of signal transduction cascades that control metal-inducible transcription. Journal of Biological Chemistry. 277:20438-20445.

Schlenk, Daniel R. and Richard T. Di Giulio. 2002. Biochemical responses as indicators of aquatic ecosystem health. In: Biological Indicators of Aquatic Ecosystem Stress. American Fisheries Society, Bethesda, MD. pp.13-422.

Seidler, Fredric J., S. Padilla, and Theodore A. Slotkin. 2002. Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?. Environmental Health Perspectives. 110(11):1097-1103.

Slotkin, Theodore A., Charlotte A. Tate, Mandy M. Cousins, and Fredric J. Seidler. 2002. Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure. Developmental Brain Research. 133(2):163-173.

Wassenberg, Deena M., Erin E. Swails, and Richard T. Di Giulio. 2002. Effects of combined exposures to benzo[a]pyrene and 3,3′,4,4′,5-pentachlorobiphenyl on Fundulus heteroclitus. Marine Environmental Research. 54(3-5):279-283.

Yanai, Joseph, O. Vatury, and Theodore A. Slotkin. 2002. Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis. Annals of the New York Academy of Sciences. 965:473-478.

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2001

Arthur, David and Edward D. Levin. 2001. Spatial and non-spatial visual discrimination learning in zebrafish (Danio rerio). Animal Cognition. 4:125-131.

Buznikov, Gennady A., V.V. Bezuglov, Lyudmila A. Nikitina, Theodore A. Slotkin, and Jean M. Lauder. 2001. Cholinergic regulation of sea urchin embryonic and larval development. Russian Journal of Physiology. 87(11):1548-1556.

Buznikov, Gennady A., Lyudmila A. Nikitina, V.V. Bezuglov, Jean M. Lauder, S. Padilla, and Theodore A. Slotkin. 2001. An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae. Environmental Health Perspectives. 109(7):651-661.

Garcia, S.J., Fredric J. Seidler, T.L. Crumpton, and Theodore A. Slotkin. 2001. Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. Brain Research. 891(1-2):54-68.

Levin, Edward D., Nii Addy, A. Nakajima, N. Channelle Christopher, Fredric J. Seidler, and Theodore A. Slotkin. 2001. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Developmental Brain Research. 130(1):83-89.

Mattie, Michael D. and Jonathan H. Freedman. 2001. Protective effects of aspirin and Vitamin E (a-tocopherol) against copper- and cadmium-induced toxicity. Biochemical and Biophysical Research Communications. 285(4):921-925.

Navarro, H.A., P.V. Basta, Fredric J. Seidler, and Theodore A. Slotkin. 2001. Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect?. Developmental Brain Research. 130(2):249-252.

Raines, K.W., Fredric J. Seidler, and Theodore A. Slotkin. 2001. Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. Developmental Brain Research. 130(1):65-72.

Seidler, Fredric J. and Theodore A. Slotkin. 2001. Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells. Environmental Health Perspectives. 109(9):909-913.

Slotkin, Theodore A., Mandy M. Cousins, Charlotte A. Tate, and Fredric J. Seidler. 2001. Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Research. 902(2):229-243.

Sutton, D., Zbigniew Kabala, A.B. Francisco, and Dharni Vasudevan. 2001. Limitations and Potential of Commercially Available Rhodamine WT as a Groundwater Tracer. Water Resources Research. 37(6):1641-1656.

Toomey, Barbara H., Susan M. Bello, Mark E. Hahn, Susannah Cantrell, Peggy Wright, Donald E. Tillitt, and Richard T. Di Giulio. 2001. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquatic Toxicology. 53(2):127-138.

Vasudevan, Dharni, R.L. Fimmen, and A.B. Francisco. 2001. Tracer Grade Rhodamine WT: Structure of constituent isomers and their sorption behavior. Environmental Science & Technology. 35(20):4089-4096.

Willett, Kristine L., Laila Lienesch, William Reichert, and Richard T. Di Giulio. 2001. In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon (PAH) fluoranthene. Toxicology and Applied Pharmacology. 177(3):264-271.

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2000

Auman, J.T., Fredric J. Seidler, and Theodore A. Slotkin. 2000. Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity. Developmental Brain Research. 121(1):19-27.

Cioci, L.K., Ling Qui, and Jonathan H. Freedman. 2000. Transgenic strains of the nematode caenorhabditis elegans as biomonitors metal contamination. Environmental Toxicology and Chemistry. 19(8):2122-2129.

Crumpton, T.L., Fredric J. Seidler, and Theodore A. Slotkin. 2000. Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation. Brain Research. 857(2):80-98.

Crumpton, T.L., Fredric J. Seidler, and Theodore A. Slotkin. 2000. Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?. Developmental Brain Research. 121(2):189-195.

Dam, K., Fredric J. Seidler, and Theodore A. Slotkin. 2000. Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. Developmental Brain Research. 121(2):179-187.

Tcherepanova, Irina, Lokesh Bhattacharyya, Charles S. Rubin, and Jonathan H. Freedman. 2000. Aspartic Proteases from the Nematode Caenorhabditis elegans. STRUCTURAL ORGANIZATION AND DEVELOPMENTAL AND CELL-SPECIFIC EXPRESSION OF asp-1. Journal of Biological Chemistry. 275(34):26359-26369.

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