UPEH Faculty

Christopher Counter (Pharmacology & Cancer Biology): Studies processes of carcinogenesis, through which we can relate environmental toxicities to genetic alterations in cancer, which directly impacts environmental health.

Gayathri Devi (Pathology): Studies dysregulation of the cell death pathway in anti-cancer therapy, and how environmental toxicants influence anti-cancer drug therapy.

Richard Di Giulio (Nicholas School of the Environment): Focuses on molecular and organismal responses of aquatic animals to environmental stressors, particularly contaminants. The laboratory is concerned with both basic studies of mechanisms of contaminant metabolism, adaptation and toxicity, and with the development of sensitive, mechanistically-based indices of exposure and toxicity that can be used in biomonitoring of free-living organisms. Additionally, through collaborations, I seek innovative approaches for elucidating linkages between human and ecological health. Current research activities are focused on the following three subjects: 1) the effects of PAHs on embryonic development, later life consequences, and adaptations in fish models, including mechanistic laboratory studies and field studies; 2) the effects of nanomaterials on vertebrate development, including interactions with other environmental variables such as UV radiation, organic matter, temperature and other contaminants; 3) the impacts of fossil fuel extraction, use and waste disposal on human and ecological health.

P. Lee Ferguson (joint Pratt School of Engineering and Nicholas Schools): Development of technologies for the trace detection of carbon-based nanomaterials and hydrophilic organic contaminants in environmental samples, and mechanisms of xenoestrogens toxicity.

Michael Foster (Medicine): Fully translational, using applied methods of approach in humans, animal models, and in vitro, investigates mechanisms of injury of urban air pollutants upon the pulmonary system.

Katherine Franz (Chemistry): Dr. Franz’s lab develops small molecules that can correct metal imbalances including those caused by environmental exposures.

Geoffrey Ginsburg (Pathology): Director of the Center for Applied Genomics and Precision Medicine; Dr. Ginsburg’s Center provides an environment for translational genomic activities for investigators who are interested in the multi-omic genomic and statistical modeling approaches to environmental exposures and perturbations in humans as well as for evaluating transitions from health and disease states.

Michael D. Gunn (Immunology, Pathology): Dr. Gunn’s lab studies mechanisms of chemical-induced lung injury and the development of therapeutics to prevent or treat such injury.

Elizabeth Hauser (Medicine): Develops statistical methods for genetic and genomic models, and develops software for the application of those statistical methods to gene discovery in complex human traits contributing to cardiovascular disease and aging, including gene x environment interactions. Areas of application include studies of the interaction between genes and air pollution in cardiovascular disease.

David Hinton (Nicholas School of the Environment): Uses fish models to study the effect of environmental toxicants upon early life stage development in vertebrates.

Helen Hsu-Kim (Pratt School of Engineering):  Studies the environmental geochemistry and microbial transformations of trace element pollutants such as mercury, zinc, selenium, and metal-based nanomaterials.

Dana Hunt (Duke Marine Lab): My research focus is on understanding the ecology of microbes through examination of their genes and lifestyles. Another area of active research is the response and adaptation of bacteria to emerging pollutants such as antibiotics and nanoparticles.

Michael Kastan (Pharmacology & Cancer Biology; Duke Cancer Institute): Studies DNA damage and general stress signaling pathways, with a particular focus on ionizing irradiation, the ATM and p53 pathways, and DNA repair.

Randall Kramer (Nicholas School of the Environment): Focuses on the relationships between ecosystem health and human health, especially the control of malaria and other infectious diseases.

Cynthia Kuhn (Pharmacology & Cancer Biology): Studies monoamine-system neurotoxins including those which kill DA neurons, and recently gonadal steroid modulation of neuroinflammatory damage of DA neurons that is highly appropriate for the UPEH.

Edward Levin (Psychology and Neuroscience): Studies toxicological influences on learning and memory, utilizing both rodent and zebrafish models to study toxicant exposures, including insecticides and heavy metals.

Chuan-Yuan Li (Dermatology and Pharmacology & Cancer Biology): Studies tumor response to therapy; stem cell and regenerative medicine; and mechanisms of carcinogenesis.

Wolfgang Liedtke (Neurobology):  Studies upper respiratory signal transduction including dysregulation of neuronal chloride homeostasis by environmental pollutants.

H. Kim Lyerly (Pathology): Investigates the response of human tissue and organs to external stress, including inflammation and therapeutic agents, and applies insights to create biomarker and imaging strategies for  human stress responses, including environmental stressors.

Donald McDonnell (Pharmacology & Cancer Biology):  Studies molecular mechanisms through which both therapeutic agents and endocrine disrupters modulate cell function.

Joel Meyer (Nicholas School of the Environment): Studies the toxicity and genotoxicity of environmental contaminants including polycyclic aromatic hydrocarbons and nanomaterials, with a particular focus on gene-environment interactions. For more detailed information, visit the Meyer lab website here!

Susan Murphy (Pathology; Obstetrics & Gynecology):  Analyzes epigenetic changes that occur in response to environmental exposures; studies the role of epigenetics in human malignancies and investigates novel treatment strategies.

William Pan (Nicholas School of the Environment): Within the Global Health Institute focuses on the interface between human activities and the environment, especially the demographic, health, and environmental outcomes of these interactions.

Steven Patierno (Cancer Institute): Studies mechanisms of respiratory toxicity and carcinogenesis by toxic metals.

Claude Piantadosi (Pathology): Studies the integrated response to acute inflammatory stressors, especially in animal models of severe sepsis and lung injury.

John Rawls (Department of Molecular Genetics and Microbiology): Studies how intestinal microbiota interact with host genome-encoded
processes to impact vertebrate health and disease.

Daniel Richter (Nicholas School of the Environment): Studies soils, ecosystems, and the wider environment. Studies how humanity is transforming Earth’s soils from natural to human-natural systems, specifically how land-uses alter soil processes and properties on different time scales.

Victoria Seewaldt (Pharmacology & Cancer Biology): Conducts multi-disciplinary, multi-institutional collaborations with basic, translational, and clinical scientists, with the goal of integrating novel functional imaging strategies with risk-marker to evaluate both environmental and epigenetic markers of cancer risk.

Theodore Slotkin (Pharmacology & Cancer Biology): Studies the effects of environmental toxicants including insecticides and nanoparticles on brain development.

Heather Stapleton (Nicholas School of the Environment): Investigates the sources, fate, transport and transformation of flame retardant contaminants in the environment, and mechanisms of thyroid system disruption.

Dennis Thiele (Pharmacology & Cancer Biology): The Thiele lab focuses on two areas of research. In one, we study how metals such a copper and the anti-cancer drug cisplatin exhibit toxicity through studies of their transport, intracellular trafficking, metal-responsive gene expression and detoxification mechanisms. Our studies encompass normal homeostatic controls and mechanisms involving fungal pathogenesis and cancer. We also investigate the role of the Heat Shock Transcription Factors (HSFs) in sensing and responding to environmental conditions (heat, chemicals) that cause protein misfolding and how HSFs function in human disease in cellular and mouse models.

Avner Vengosh (Nicholas School of the Environment): Studies the environmental fate, including ground waters and humans, of trace metals and radionuclides.

Tuan Vo Dinh (Pratt School of Engineering): Develops nano-sensors, biosensors and biochips for the protection of the environment and the improvement of human health.

Mark Wiesner (Pratt School of Engineering): Studies mechanisms controlling the transport and fate of materials in the environment, approaches for quantifying the health risks associated with these materials, and technologies for water and wastewater treatment.

Tso-Pang Yao (Pharmacology and Cancer Biology): Studies the regulatory functions of protein acetylation in cell signaling and human disease.

Jim Zhang (Nicholas School of the Environment and Global Health Institute): Develops novel biomarkers of human exposure and health effects, assesses health and climate co-benefits of air pollution interventions, evaluates technologies and policies for reducing environmental pollution and disease burdens, and examines biological mechanisms underlying adverse effects of environmental exposure.

UPEH Adjunct Faculty

–NIEHS– Linda Birnbaum  Paul Foster  William Copeland  –U.S. EPA– Phillip Bushnell Kevin Crofton  Stephanie Padilla  –North Carolina Central University– Yolanda Banks Anderson Greg Cole  –North Carolina State University– Seth Kullman  Gerald LeBlanc  Robert Smart –University of North Carolina– James Swenberg  

View page »