ITEHP Faculty

Richard Auten (Medicine): Studies the impact of chemical exposures during pregnancy and how they affect fetal programming and postnatal development, including fetal inflammatory responses that result from maternal exposure to industrial particles and traffic-related diesel exhaust exposure.

Christopher Counter (Pharmacology & Cancer Biology): Studies processes of carcinogenesis, through which we can relate environmental toxicities to genetic alterations in cancer, which directly impacts environmental health.

Gaythri Devi (Pathology): Studies dysregulation of the cell death pathway in anti-cancer therapy, and how environmental toxicants influence anti-cancer drug therapy.

Richard Di Giulio (Nicholas School of the Environment): Studies mechanisms by which environmental contaminants including PAHs and nanomaterials affect vertebrate development, particularly of the cardiovascular system, using fish models such as the zebrafish.

P. Lee Ferguson (joint Pratt and Nicholas Schools): Development of technologies for the trace detection of carbon-based nanomaterials and hydrophilic organic contaminants in environmental samples, and mechanisms of xenoestrogens toxicity.

Michael Foster (Medicine): Fully translational, using applied methods of approach in humans, animal models, and in vitro, investigates mechanisms of injury of urban air pollutants upon the pulmonary system.

Katherine Franz (Chemistry): Dr. Franz’s lab develops small molecules that can correct metal imbalances including those caused by environmental exposures.

Geoffrey Ginsburg (Pathology): As Director of the Center for Genomic Medicine in the Duke Institute for Genome Sciences & Policy (IGSP), Dr. Ginsburg provides an environment for translational activities for investigators who are interested in the genomic approaches to both environmental exposures as well as for evaluating health and disease.

Michael D. Gunn (Immunology, Pathology): Dr. Gunn’s lab studies mechanisms of chemical-induced lung injury and the development of therapeutics to prevent or treat such injury.

Elizabeth Hauser (Medicine): Develops statistical methods for genetic and genomic models, and develops software for the application of those statistical methods to gene discovery in complex human traits contributing to cardiovascular disease and aging, including gene x environment interactions.

David Hinton (Nicholas School of the Environment): Uses fish models to study the effect of environmental toxicants upon early life stage development in vertebrates.

John Hollingsworth (Immunology): Studies the role of genes of innate immunity in the biological response to common inhaled toxicants and environmental epigenetics.

Catherine Hoyo (Medicine):  Investigates underlying factors for differences in the occurrence of cancers of the esophagus and prostate between individuals of African descent and others, with a focus on genetic and epigenetics of growth-related genes, and how these interact with environmental exposures to influence cancer risks.

Helen Hsu-Kim (Pratt School):  Studies mercury biogeochemistry and the environmental fate of other metals, metalloids and metal-based nanoparticles.

Michael Kastan (Pharmacology & Cancer Biology): Studies DNA damage and mitochondrial oxidative stress caused by ionizing radiation and other stimuli and their involvement in the etiology of cancer.

Randall Kramer (Nicholas School): Within the Global Health Institute, focuses on the relationships between ecosystem health and human health, especially water quality and sanitation.

Cynthia Kuhn (Pharmacology & Cancer Biology): Studies monoamine-system neurotoxins including those which kill DA neurons, and recently gonadal steroid modulation of neuroinflammatory damage of DA neurons that is highly appropriate for the UPEH.

Edward Levin (Psychology and Neuroscience): Studies toxicological influences on learning and memory, utilizing both rodent and zebrafish models to study toxicant exposures, including insecticides and heavy metals.

Chuan-Yuan Li (Dermatology and Pharmacology & Cancer Biology): Studies tumor response to therapy, with a special emphasis on skin cancer; stem cell and regenerative medicine; and mechanisms of carcinogenesis.

Wolfgang Liedtke (Neurobology):  Studies upper respiratory signal transduction including dysregulation of neuronal chloride homeostasis by environmental pollutants.

H. Kim Lyerly (Pathology): Investigates the response of human tissue and organs to external stress, including inflammation and therapeutic agents, and applies insights to create biomarker and imaging strategies for  human stress responses, including environmental stressors.

Donald McDonnell (Pharmacology & Cancer Biology):  Studies molecular mechanisms through which both therapeutic agents and endocrine disrupters modulate cell function.

Joel Meyer (Nicholas School of the Environment): Studies the toxicity and genotoxicity of environmental contaminants including polycyclic aromatic hydrocarbons and nanomaterials, with a particular focus on gene-environment interactions.

Susan Murphy (Pathology; Obstetrics & Gynecology):  Analyzes epigenetic changes that occur as a result of environmental exposures in utero as well as those that predispose to malignancy in humans.

William Pan (Nicholas School): Within the Global Health Institute focuses on the interface between human activities and the environment, especially the demographic, health, and environmental outcomes of these interactions.

Steven Patierno (Cancer Institute): Studies mechanisms of respiratory toxicity and carcinogenesis by toxic metals.

Claude Piantadosi (Pathology): Studies the integrated response to acute inflammatory stressors, especially in animal models of severe sepsis and lung injury.

Victoria Seewaldt (Pharmacology & Cancer Biology): Conducts multi-disciplinary, multi-institutional collaborations with basic, translational, and clinical scientists, with the goal of integrating novel functional imaging strategies with risk-marker to evaluate both environmental and epigenetic markers of cancer risk.

Theodore Slotkin (Pharmacology & Cancer Biology): Studies the effects of environmental toxicants including insecticides and nanoparticles on brain development.

Heather Stapleton (Nicholas School of the Environment): Investigates the sources, fate, transport and transformation of flame retardant contaminants in the environment, and mechanisms of thyroid system disruption.

Dennis Thiele (Pharmacology & Cancer Biology): The Thiele lab investigates how metals such as copper and the anti-cancer drug cisplatin exhibit toxicity through studies of their transport , intracellular trafficking, metal-responsive gene expression and detoxification mechanisms. Our studies encompass normal homeostatic controls and mechanisms involving fungal pathogenesis and cancer.

Avner Vengosh (Nicholas School of the Environment): Studies the environmental fate, including ground waters and humans, of trace metals and radionuclides.

Tuan Vo Dinh (Pratt School): Develops nano-sensors, biosensors and biochips for the protection of the environment and the improvement of human health.

Mark Wiesner (Pratt School): Studies mechanisms controlling the transport and fate of nanomaterials in the environment, and approaches for quantifying the health risks associated with these materials.

Jim Zhang (Nicholas School and Global Health): Develops novel biomarkers of human exposure and health effects, assesses health and climate co-benefits of air pollution interventions, and examines biological mechanisms by which environmental exposures exert adverse health effects.

ITEHP Adjunct Faculty

–National Center for Toxicological Research– Syed Ali  –NIEHS– Linda Birnbaum  Paul Foster  William Copeland  Jonathan Freedman  –U.S. EPA– Phillip Bushnell Kevin Crofton  Virginia Moser Stephanie Padilla  –North Carolina Central University– Yolanda Banks Anderson Greg Cole  –North Carolina State University– Seth Kullman  Gerald LeBlanc  Robert Smart  –University of North Carolina– James Swenberg –The Hamner Institutes for …

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